Positions in yeast labs

Syngenta Ltd., UK

We have a 9 month position due to maternity leave in our Mode of Action Technology group available ASAP. The position will be administered by Kelly Services Ltd. http://www.kellyservices.co.uk/web/uk/services/en/pages/.

Salary will be based on skills and experience

Brief job description:

Our New Technologies team in the Mode of Action Technology group uses and develops new functional genomic and biochemical tools to rapidly elucidate the mode of action of lead chemicals. Your role will involve using a range of molecular biology, genetic and biochemical techniques in both yeast and plant pathogenic fungi. This will involve constructing various plasmids and overseeing transformations, growth assays and mutagenesis as well as presenting your findings to your team leader and others. The ideal candidate would be highly proficient in molecular biology gained through on the job training of through formal training, degree, MSc or PhD. Either way, you’ll have an knowledge of molecular & cell biological techniques and be able to work independently or as part of a team. The ability to work flexibly across multiple projects while meeting deadlines and health & safety standards will also be key.

Applicants should email their cv and names/email address of three references to michael.csukai@syngenta.com.

University of New Mexico

Post doctoral position available now at the University of New Mexico, Albuquerque to study differentiation of quiescent and non-quiescent cells in yeast stationary phase cultures. This position is for a beginning post doc and applicants should have a strong background in yeast genetics, genomics, or flow cytometry. For recent work see Mol. Biol. Cell 2008 19: 1271-1280; and http://biology.unm.edu/biology/maggieww/public_html/Maggieww.html.

Applicants should email their cv and names/email address of three references to Maggie Werner-Washburne, maggieww@unm.edu.

Duke University Medical Center

NIH-funded postdoctoral positions are available at Duke University Medical Center to study quantitative (complex) traits in “S. cerevisiae”; for example, see Nature 416:326-330 (2002) and PLoS Genetics 2(2):e13 (2006).

Applicants should have 0 to (at most) 2 years of post-doctoral experience and a strong background in at least one of three areas – yeast genetics, quantitative/population genetics and/or genomics/informatics – and a desire to expand into the other listed areas. Start dates are flexible.

See the lab website for more information and publications. Applicants should email their curriculum vitae and the names/email addresses of three references to John McCusker. Email: mccus001@mc.duke.edu

University of Washington Genome Sciences Dept, Seattle, USA

Maitreya Dunham is moving her lab from Princeton to UW this summer, and is looking for postdoc applicants. The Dunham Lab studies evolution and systems biology in yeast from a genomic perspective. Lab interests include

• experimental evolution over a variety of conditions and genotypes
• integrating mutation and gene expression data
• aneuploidy and genome rearrangement effects on fitness and relation with transposons
• comparative genomics using S. bayanus
• gene expression and genome evolution in hybrid yeasts
• technology development for chemostats, whole genome characterization, and other applications

For more information and publications, see the lab website. Email inquiries to maitreya@u.washington.edu

Carnegie Institution for Science, Stanford, California, USA

Highly qualified and motivated individuals are invited to send applications for a Postdoc Position in the Research Group of Wolf B. Frommer on the topic

Regulatory circuits controlling sugar flux in yeast grown on ethanol

HT screen of the yeast knock out collection using FRET sensors for glucose, sucrose and maltose, follow-up analysis of hits and reconstruction of networks

Our lab has developed a wide range of FRET sensors for metabolites. These sensors have so far been used mainly in mammalian cells to study glutamate release from neurons, glucose transport across the ER membrane or tryptophan/kynurenine exchange.

We have now been able to functionally express the FRET sensors also in the cytoplasm of yeast and to establish a high throughput screening platform. Our goal is to identify novel regulatory pathways involved in the control of glucose flux in yeast. As a first step, the kinase k.o. collection has been screened for altered glucose flux and several hits have been identified and verified.

Next steps will be to verify the hits using a new microfluidic platform, to test the effect on other sugar fluxes using FRET sensors for sucrose, maltose and ribose and to place the kinases into signaling networks. The screen can be expanded to include the whole genome at a later stage. Focus points are regulatory effects on glucose transporters and hexokinases. Due to the advanced stage, it is expected that the work will lead to high profile publications within less than a year.

Start date asap

Send your application with CV and the names of three references to:

Wolf B. Frommer Carnegie Institution for Science 260 Panama St, Stanford CA 94305 USA. Website[1] E-mail: wfrommer@stanford.edu

Stony Brook University

A Postdoctoral position available to study the regulation of signaling and morphogenesis in Candida albicans. The primary responsibility is to develop an independent research project focused on studying the mechanisms by which this organism responds to extracellular signals to switch from budding to hyphal growth. Specific research efforts will focus on studying the role of plasma membrane organization in morphogenesis and virulence factor production. Recent references related to this project: [2] [3] [4] [5]

Research will be carried out in the Center for Yeast Molecular Genetics and Cell Biology, which includes 8 labs working on different aspects of fungal biology.

Applicants should have a strong background in genetics, biochemistry, and cell biology. Prior experience in working with yeast or fungi is preferred, but not essential.

Applicants should email their CV and contact information for three references (including email address) to James Konopka jkonopka@ms.cc.sunysb.edu

James Konopka, Ph.D. Professor Department of Molecular Genetics and Microbiology Stony Brook University Stony Brook, NY 11794-5222