Difference between revisions of "YDL139C"

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'''Description of YDL139C:''' Protein of unknown function; contains nuclear export signal (NES); associates with CEN DNA; required for G2/M progression and localization of Cse4p; isolated as a high-copy suppressor of mutations in the histone fold domain (HFD) of CSE4<ref name='S000122928'>Stoler S, et al. (2007) Scm3, an essential Saccharomyces cerevisiae centromere protein required for G2/M progression and Cse4 localization. Proc Natl Acad Sci U S A 104(25):10571-6 {{SGDpaper|S000122928}} PMID 17548816</ref><ref name='S000052739'>Chen Y, et al. (2000) The N terminus of the centromere H3-like protein Cse4p performs an essential function distinct from that of the histone fold domain. Mol Cell Biol 20(18):7037-48
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'''Description of YDL139C:''' Nonhistone component of centromeric chromatin that binds stoichiometrically to CenH3-H4 histones, required for kinetochore assembly; contains nuclear export signal (NES); required for G2/M progression and localization of Cse4p<ref name='S000123881'>Aravind L, et al. (2007) Domain Architectures of the Scm3p Protein Provide Insights into Centromere Function and Evolution. Cell Cycle 6(20) {{SGDpaper|S000123881}} PMID 17704645</ref><ref name='S000122928'>Stoler S, et al. (2007) Scm3, an essential Saccharomyces cerevisiae centromere protein required for G2/M progression and Cse4 localization. Proc Natl Acad Sci U S A 104(25):10571-6 {{SGDpaper|S000122928}} PMID 17548816</ref><ref name='S000052739'>Chen Y, et al. (2000) The N terminus of the centromere H3-like protein Cse4p performs an essential function distinct from that of the histone fold domain. Mol Cell Biol 20(18):7037-48
 
  {{SGDpaper|S000052739}} PMID 10958698</ref>
 
  {{SGDpaper|S000052739}} PMID 10958698</ref>
 
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Revision as of 13:05, 31 August 2007

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Systematic name YDL139C
Gene name SCM3
Aliases
Feature type ORF, Verified
Coordinates Chr IV:212047..211376
Primary SGDID S000002298


Description of YDL139C: Nonhistone component of centromeric chromatin that binds stoichiometrically to CenH3-H4 histones, required for kinetochore assembly; contains nuclear export signal (NES); required for G2/M progression and localization of Cse4p[1][2][3]




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References

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  1. Aravind L, et al. (2007) Domain Architectures of the Scm3p Protein Provide Insights into Centromere Function and Evolution. Cell Cycle 6(20) SGD PMID 17704645
  2. Stoler S, et al. (2007) Scm3, an essential Saccharomyces cerevisiae centromere protein required for G2/M progression and Cse4 localization. Proc Natl Acad Sci U S A 104(25):10571-6 SGD PMID 17548816
  3. Chen Y, et al. (2000) The N terminus of the centromere H3-like protein Cse4p performs an essential function distinct from that of the histone fold domain. Mol Cell Biol 20(18):7037-48 SGD PMID 10958698

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