Difference between revisions of "YMR167W"
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| − | '''Description of YMR167W:''' Protein required for mismatch repair in mitosis and meiosis | + | '''Description of YMR167W:''' Protein required for mismatch repair in mitosis and meiosis as well as crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p duing mismatch repair; human homolog is associated with hereditary non-polyposis colon cancer<ref name='S000072741'>Argueso JL, et al. (2003) Systematic mutagenesis of the Saccharomyces cerevisiae MLH1 gene reveals distinct roles for Mlh1p in meiotic crossing over and in vegetative and meiotic mismatch repair. Mol Cell Biol 23(3):873-86 {{SGDpaper|S000072741}} PMID 12529393</ref><ref name='S000064102'>Habraken Y, et al. (1997) Enhancement of MSH2-MSH3-mediated mismatch recognition by the yeast MLH1-PMS1 complex. Curr Biol 7(10):790-3 {{SGDpaper|S000064102}} PMID 9368761</ref><ref name='S000057711'>Strand M, et al. (1993) Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair. Nature 365(6443):274-6 {{SGDpaper|S000057711}} PMID 8371783</ref><ref name='S000057619'>Bronner CE, et al. (1994) Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer. Nature 368(6468):258-61 |
| − | {{SGDpaper| | + | {{SGDpaper|S000057619}} PMID 8145827</ref> |
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Revision as of 13:05, 10 April 2007
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| Systematic name | YMR167W |
| Gene name | MLH1 |
| Aliases | PMS2 |
| Feature type | ORF, Verified |
| Coordinates | Chr XIII:594885..597194 |
| Primary SGDID | S000004777 |
Description of YMR167W: Protein required for mismatch repair in mitosis and meiosis as well as crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p duing mismatch repair; human homolog is associated with hereditary non-polyposis colon cancer[1][2][3][4]
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References
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- ↑ Argueso JL, et al. (2003) Systematic mutagenesis of the Saccharomyces cerevisiae MLH1 gene reveals distinct roles for Mlh1p in meiotic crossing over and in vegetative and meiotic mismatch repair. Mol Cell Biol 23(3):873-86 SGD PMID 12529393
- ↑ Habraken Y, et al. (1997) Enhancement of MSH2-MSH3-mediated mismatch recognition by the yeast MLH1-PMS1 complex. Curr Biol 7(10):790-3 SGD PMID 9368761
- ↑ Strand M, et al. (1993) Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair. Nature 365(6443):274-6 SGD PMID 8371783
- ↑ Bronner CE, et al. (1994) Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer. Nature 368(6468):258-61 SGD PMID 8145827
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