Difference between revisions of "YKL117W"
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| − | '''Description of YKL117W:''' Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins<ref name='S000050786'>Fang Y, et al. (1998) SBA1 encodes a yeast hsp90 cochaperone that is homologous to vertebrate p23 proteins. Mol Cell Biol 18(7):3727-34 {{SGDpaper|S000050786}} PMID 9632755</ref><ref name='S000044432'>Bohen SP (1998) Genetic and biochemical analysis of p23 and ansamycin antibiotics in the function of Hsp90-dependent signaling proteins. Mol Cell Biol 18(6):3330-9 | + | '''Description of YKL117W:''' Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins and like p23 can regulate telomerase activity<ref name='S000122064'>Toogun OA, et al. (2007) The p23 molecular chaperone promotes functional telomerase complexes through DNA dissociation. Proc Natl Acad Sci U S A () {{SGDpaper|S000122064}} PMID 17389357</ref><ref name='S000050786'>Fang Y, et al. (1998) SBA1 encodes a yeast hsp90 cochaperone that is homologous to vertebrate p23 proteins. Mol Cell Biol 18(7):3727-34 {{SGDpaper|S000050786}} PMID 9632755</ref><ref name='S000044432'>Bohen SP (1998) Genetic and biochemical analysis of p23 and ansamycin antibiotics in the function of Hsp90-dependent signaling proteins. Mol Cell Biol 18(6):3330-9 |
{{SGDpaper|S000044432}} PMID 9584173</ref> | {{SGDpaper|S000044432}} PMID 9584173</ref> | ||
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Revision as of 14:05, 3 April 2007
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| Systematic name | YKL117W |
| Gene name | SBA1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XI:219968..220618 |
| Primary SGDID | S000001600 |
Description of YKL117W: Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins and like p23 can regulate telomerase activity[1][2][3]
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References
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- ↑ Toogun OA, et al. (2007) The p23 molecular chaperone promotes functional telomerase complexes through DNA dissociation. Proc Natl Acad Sci U S A () SGD PMID 17389357
- ↑ Fang Y, et al. (1998) SBA1 encodes a yeast hsp90 cochaperone that is homologous to vertebrate p23 proteins. Mol Cell Biol 18(7):3727-34 SGD PMID 9632755
- ↑ Bohen SP (1998) Genetic and biochemical analysis of p23 and ansamycin antibiotics in the function of Hsp90-dependent signaling proteins. Mol Cell Biol 18(6):3330-9 SGD PMID 9584173
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