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| + | #REDIRECT [[YBL002W]] |
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− | {|{{Prettytable}} align = 'right' width = '200px'
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− | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YBL002W YBL002W]
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− | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''HTB2 ''
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− | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases''' ||'' ''
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− | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type''' || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]
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− | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
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− | |nowrap| Chr II:236495..236890
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− | |}
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− | '''Description of {{PAGENAME}}:''' One of two nearly identical (see HTB1) histone H2B subtypes required for chromatin assembly and chromosome function; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation<ref name='S000076743'>Yamashita K, et al. (2004) Rad6-Bre1-mediated histone H2B ubiquitylation modulates the formation of double-strand breaks during meiosis. Proc Natl Acad Sci U S A 101(31):11380-5 {{SGDpaper|S000076743}} PMID 15280549</ref><ref name='S000075526'>Kao CF, et al. (2004) Rad6 plays a role in transcriptional activation through ubiquitylation of histone H2B. Genes Dev 18(2):184-95 {{SGDpaper|S000075526}} PMID 14752010</ref><ref name='S000072664'>Hwang WW, et al. (2003) A conserved RING finger protein required for histone H2B monoubiquitination and cell size control. Mol Cell 11(1):261-6 {{SGDpaper|S000072664}} PMID 12535538</ref><ref name='S000070336'>Briggs SD, et al. (2002) Gene silencing: trans-histone regulatory pathway in chromatin. Nature 418(6897):498 {{SGDpaper|S000070336}} PMID 12152067</ref><ref name='S000070308'>Dover J, et al. (2002) Methylation of histone H3 by COMPASS requires ubiquitination of histone H2B by Rad6. J Biol Chem 277(32):28368-71 {{SGDpaper|S000070308}} PMID 12070136</ref><ref name='S000069711'>Martini EM, et al. (2002) A role for histone H2B during repair of UV-induced DNA damage in Saccharomyces cerevisiae. Genetics 160(4):1375-87 {{SGDpaper|S000069711}} PMID 11973294</ref><ref name='S000039551'>Robzyk K, et al. (2000) Rad6-dependent ubiquitination of histone H2B in yeast. Science 287(5452):501-4
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− | {{SGDpaper|S000039551}} PMID 10642555</ref>
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− | __TOC__
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− | ==Community Commentary==
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− | {{CommentaryHelp}}
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− | ==References==
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− | <!-- REFERENCES ARE AUTOMATICALLY GENERATED. PLEASE DON'T EDIT THIS SECTION-->
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− | {{RefHelp}}
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− | </protect>
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