Difference between revisions of "YOL006C"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl? | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000005366 YOL006C] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''TOP1 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''TOP1 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
|nowrap| Chr XV:315388..313079 | |nowrap| Chr XV:315388..313079 | ||
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| + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000005366 | ||
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| − | '''Description of | + | '''Description of YOL006C:''' Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination<ref name='S000074598'>Woo MH, et al. (2003) Locking the DNA topoisomerase I protein clamp inhibits DNA rotation and induces cell lethality. Proc Natl Acad Sci U S A 100(24):13767-72 {{SGDpaper|S000074598}} PMID 14585933</ref><ref name='S000065460'>Roca J (1995) The mechanisms of DNA topoisomerases. Trends Biochem Sci 20(4):156-60 {{SGDpaper|S000065460}} PMID 7770916</ref><ref name='S000055801'>Thrash C, et al. (1985) Cloning, characterization, and sequence of the yeast DNA topoisomerase I gene. Proc Natl Acad Sci U S A 82(13):4374-8 |
{{SGDpaper|S000055801}} PMID 2989818</ref> | {{SGDpaper|S000055801}} PMID 2989818</ref> | ||
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J Biol Chem 278(5):3265-74</ref> | J Biol Chem 278(5):3265-74</ref> | ||
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Revision as of 07:46, 27 February 2007
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| Systematic name | YOL006C |
| Gene name | TOP1 |
| Aliases | MAK1, MAK17 |
| Feature type | ORF, Verified |
| Coordinates | Chr XV:315388..313079 |
| Primary SGDID | S000005366 |
Description of YOL006C: Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination[1][2][3]
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Contents
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References
See Help:References on how to add references
- ↑ Woo MH, et al. (2003) Locking the DNA topoisomerase I protein clamp inhibits DNA rotation and induces cell lethality. Proc Natl Acad Sci U S A 100(24):13767-72 SGD PMID 14585933
- ↑ Roca J (1995) The mechanisms of DNA topoisomerases. Trends Biochem Sci 20(4):156-60 SGD PMID 7770916
- ↑ Thrash C, et al. (1985) Cloning, characterization, and sequence of the yeast DNA topoisomerase I gene. Proc Natl Acad Sci U S A 82(13):4374-8 SGD PMID 2989818
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