Difference between revisions of "YPR200C"
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Revision as of 12:02, 21 February 2007
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| Systematic name | YPR200C |
| Gene name | ARR2 |
| Aliases | ACR2 |
| Feature type | ORF, Verified |
| Coordinates | Chr XVI:939667..939275 |
Description of YPR200C: Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p[1][2]
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Contents
Community Commentary
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Other
Other
Acr2p is an arsenate reductase that is related to protein phosphotyrosine phosphateses. The active site of Acr2p has the consensus phosphatese HC(X)5R motif. [3] [4]
Purified Acr2p reduces arsenate to arsenite using glutaredoxin and GSH as reductants. [2] [4]
Protein Details
Protein Function/Process
Disruption of ACR2 resulted in senstivity to arsenate but not arsenite. Purified Acr2p was shown to have arsenate reductase activity. [1] [4]
Acr2p, which is related to protein phosphotyrosine phosphatases, has arsenate reductase activity but not protein phosphotyrosine phosphatase activity. Three mutations were sufficient to change the activity from a reductase to a phosphatase. [5] [4]
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References
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- ↑ 1.0 1.1 Mukhopadhyay R and Rosen BP (1998) Saccharomyces cerevisiae ACR2 gene encodes an arsenate reductase. FEMS Microbiol Lett 168(1):127-36 SGD PMID 9812373
- ↑ 2.0 2.1 Mukhopadhyay R, et al. (2000) Purification and characterization of ACR2p, the Saccharomyces cerevisiae arsenate reductase. J Biol Chem 275(28):21149-57
SGD PMID 10801893 Cite error: Invalid
<ref>tag; name "S000054698" defined multiple times with different content - ↑ Mukhopadhyay R and Rosen BP (2001) The phosphatase C(X)5R motif is required for catalytic activity of the Saccharomyces cerevisiae Acr2p arsenate reductase. J Biol Chem 276(37):34738-42 SGD PMID 11461905
- ↑ 4.0 4.1 4.2 4.3 submitted by Barry Rosen on 2003-07-31
- ↑ Mukhopadhyay R, et al. (2003) Directed evolution of a yeast arsenate reductase into a protein-tyrosine phosphatase. J Biol Chem 278(27):24476-80 SGD PMID 12711608
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