Difference between revisions of "YML004C"
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| + | Specifically higher expression in carbon limited chemostat cultures versus carbon excess. | ||
| + | <ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. | ||
| + | J Biol Chem 278(5):3265-74</ref> | ||
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Revision as of 12:02, 21 February 2007
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| Systematic name | YML004C |
| Gene name | GLO1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XIII:262685..261705 |
Description of YML004C: Monomeric glyoxalase I, catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; expression regulated by methylglyoxal levels and osmotic stress[1][2][3][4]
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References
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- ↑ Aguilera J and Prieto JA (2004) Yeast cells display a regulatory mechanism in response to methylglyoxal. FEMS Yeast Res 4(6):633-41 SGD PMID 15040952
- ↑ Frickel EM, et al. (2001) Yeast glyoxalase I is a monomeric enzyme with two active sites. J Biol Chem 276(3):1845-9 SGD PMID 11050082
- ↑ Inoue Y and Kimura A (1996) Identification of the structural gene for glyoxalase I from Saccharomyces cerevisiae. J Biol Chem 271(42):25958-65 SGD PMID 8824231
- ↑ Inoue Y, et al. (1998) Expression of the glyoxalase I gene of Saccharomyces cerevisiae is regulated by high osmolarity glycerol mitogen-activated protein kinase pathway in osmotic stress response. J Biol Chem 273(5):2977-83 SGD PMID 9446611
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