Positions in yeast labs

'==Bioinformatician / computational biologist position in yeast biology & next generation sequencing' ==

Laboratory of Biology of Yeast Colonies (www.natur.cuni.cz/~zdenap), Faculty of Science, Charles University in Prague is seeking applicants for researcher position in the field of bioinformatics. DESCRIPTION: BIOINFORMATICIAN / COMPUTATIONAL BIOLOGIST POSITION funded by Czech-Norwegian Research Program is available at the Group of Biology of Yeast Colonies (www.natur.cuni.cz/~zdenap), Faculty of Science, Charles University in Prague, Vinicna 5, Prague, Czech Republic, being a part of new scientific center of excellence “Biotechnology and Biomedicine Center of the Academy of Sciences and Charles University in Vestec”. The Research Group is interested in different aspects of yeast multicellularity including questions related to topics of cell ageing, stress defense, adaptation and longevity. The research of the group currently follows two main lines: i) Development, differentiation and signaling of yeast colonies as a model of a primitive multicellular organism, with the main goal to identify the regulatory networks and signals involved in the phenotypic differentiation between the different types of chronologically aged cells developing within the colony (related to Mol Cell 46: 436-448, 2012). ii) Development, defense strategies and signaling pathways involved in formation of biofilm colonies of wild yeast (related to J Cell Biol. 194:679-87, 2011). The candidates (i.e. bioinformaticians / computational biologists, alternatively informaticians / statisticians / big data analysts) should be interested in applying their skills in both research directions; in particular, the challenges of integrating the DNA, RNA and epigenetic data obtained by next-generation DNA/RNA sequencing methodology. The project will produce a unique dataset where the cells have been characterized at the fundamental levels of molecular biology (genetics, epigenetics and expression). We envisage that such a complete dataset will facilitate unique novel insights into the biology of the yeast model system. The bioinformatician will be expected to play a central role in data processing, integration and analysis. QUALIFICATION AND EXPERIENCE: Candidates should be comfortable at the unix / linux command line and preferably also able to write bash scripts. The candidate should also be able to program in at least one of the following languages: perl, python, java, c++, and be familiar with statistical software (preferably R). Familiarity with high through-put sequencing software is a plus: mapping tools (e.g. bwa, novoalign), expression quantification (e.g. tophat), variant calling (e.g. GATK), peak calling (e.g. MACS). Last, but not least, the candidate should be interested in applying these quantitative skills to biological data. ELIGIBILITY, HOW TO APPLY: The applicants should have good command of English and preferentially a PhD; however, researchers who have completed University education without PhD, proficient in the tools described above, are also encouraged to apply. Please send your motivation letter, CV, list of publications (including IF and the number of citations) and reference contacts directly to the group leader Zdena Palkova (zdenap@natur.cuni.cz). The contract is available from January 1, 2015 (or by appointment) and finishes at April 2017.

PhD and Post-doctoral positions in the lab of Martin Kupiec (genome stability) at Tel Aviv University, Israel, posted November 2014

We are looking highly motivated people to work on Genome Stability and telomeres in yeast. The lab http://www.tau.ac.il/lifesci/departments/biotech/members/kupiec/kupiec.html works on processes that prevent cancer by keeping the genome stable. These include the repair of broken chromosomes, the handling of stalled DNA replication forks and the maintenance of normal-length telomeres. Candidates should send a Curriculum Vitae, including past research experiences and publication records, as well as a letter detailing their motivation and interest in our work. Applicants should also request recommendation letters to be directly sent by two or three references.

Technician/Research assistant position available

A 3-year technician/research assistant position is available in the group of Dr. Damien Coudreuse (www.synthecell.org) at the Institute of Genetics and Development of Rennes (IGDR), France (http://igdr.univ-rennes1.fr/english/). Research in this laboratory takes a synthetic biology approach in fission yeast to study the architecture and evolution of cell cycle regulation. Routinely used techniques in the team include fission yeast genetics, molecular biology (DNA, RNA and protein biology) and microscopy. The role of the technician/engineer will be to provide help with such techniques to various members of the team as well as to take responsibility for a number of common tasks in the laboratory.Candidates should contact Dr. Damien Coudreuse at damien.coudreuse@univ-rennes1.fr and send a Curriculum Vitae, including past experiences, as well as a letter detailing their motivation and interest in the position. Applicants should also request recommendation letters to be directly sent by one to three references.

Post-doctoral positions available - Complexity and Variability in Cell Proliferation

Two three-year post-doctoral positions supported by a starting grant from the European Research Council (ERC) are available in the group of Dr. Damien Coudreuse (www.synthecell.org) at the Institute of Genetics and Development of Rennes (IGDR), France (http://igdr.univ-rennes1.fr/english/). Research in this laboratory takes a synthetic biology approach in fission yeast to study the architecture and evolution of cell cycle regulation. The proposed projects aim at understanding fundamental aspects of the control of cell proliferation, from the buffering of variability in the different mechanisms driving cell cycle progression to the evolution of complexity in cell cycle control.Candidates should contact Dr. Damien Coudreuse at damien.coudreuse@univ-rennes1.fr and send a Curriculum Vitae, including past research experiences and publication records, as well as a letter detailing their motivation and interest in our work. Applicants should also request recommendation letters to be directly sent by two or three references.

POSTDOCTORAL POSITION - NIH, National Cancer Institute, Posted April 16, 2014

A postdoctoral position is available within the Optical Imaging Core of the Laboratory of Receptor Biology and Gene Expression (NCI/NIH) to conduct research in the regulation of transcription in Saccharomyces cerevisiae. The candidate is expected to have a background in yeast genetics and molecular biology and to be interested in extensive live imaging by fluorescence microscopy and in super-resolution methods. Publications in the area of research: Tatiana S. Karpova, Teresa Y. Chen, Brian L. Sprague, James G. McNally. Dynamic interactions of a transcription factor with DNA are accelerated by a chromatin remodeler. EMBO Reports. 5: 1064-1070, 2004 Tatiana S. Karpova, Min J. Kim, Corentin Spriet, Kip Nalley, Tim Stasevich, Zoulika Kherrouche, Laurent Heliot, and James G. McNally. Concurrent Fast and Slow Cycling of a Transcriptional Activator at an Endogenous Promoter. Science 319: 466-469, 2008 Applicants should contact Dr. Tatiana Karpova (karpovat@mail.nih.gov) and submit their CV.

Opening for two postdoctoral positions in the Cell Signaling Research Group, UPF, Barcelona, Spain (posted April 2014)

Post description: We offer two postdoctoral research positions in the Cell Signaling Research Group led by Dr. Francesc Posas and Dr. Eulàlia de Nadal), at the Pompeu Fabra University, Barcelona, Spain. The main objective of our group is the study of the molecular mechanisms of signal transduction mediated by SAPKs (Stress Activated Protein Kinases) in yeast cells, as well as to understand the complexity of adaptive responses generated by these enzymes. Regulation of gene expression and cell cycle are two of the most important aspects for cell adaptation to stress [Nadal-Ribelles M. et al, Mol Cell (2014); Duch A. et al, Nature (2013); Nadal-Ribelles M. et al, Genome Biol (2012); de Nadal E. and Posas F., Nat. Rev. Genet. (2011); Solé C. et al., EMBO J (2011); Regot S. et al., Nature (2011)]. We are looking for a highly motivated research scientist with consolidated experience in biochemistry and/or yeast genetics to work in these fields.

The Institute: UPF is a young, public and modern university and called to become one of the leading European universities. Awarded with a CEI label (International Excellence Campus) by the Spanish Ministry of Education, UPF's indicators have made it a benchmark for the Spanish and European university systems. Our group is integrated into the Biomedical Research Park of Barcelona (PRBB), one of the largest hubs of biomedical research in southern Europe.

For more information please visit the web site: http://www.upf.edu/cellsignaling

Postdoctoral position in Cell Biology, Univ. of Miami, Florida (posted April 2014)

A Postdoctoral position is available in the lab of Dr. Sandra Lemmon, University of Miami, Miller School of Medicine. Research focuses on regulation of membrane dynamics in the yeast S. cerevisiae. Particular interests include the role of phosphorylation, the actin cytoskeleton, and lipids in endocytosis and the function of clathrin in endocytosis and sorting to the lysosome/vacuole. For information on research interests check: <http://biomed.miami.edu/?p=482&pid=208&m=facultyph&mid=0&item=9>.

Qualifications: Candidates should have a PhD in chemistry, biology, genetics or a related life science. Applicants with a background in cell biology, yeast genetics and molecular biology, fluorescence microscopy and/or lipid biochemistry are especially encouraged to apply. Please submit a curriculum vitae, publications, summary of past research experiences, research interests, and the names of three references to: Dr. Sandra Lemmon at <slemmon[at]miami[dot]edu>.

Postdoctoral Fellowship in yeast evolutionary genomics at Stanford University, March 2014

The Fraser Lab in the Department of Biology is seeking a postdoctoral fellow to work on the evolution of gene expression in Saccharomyces yeast. The exact subject is flexible, but will likely involve using RNA-seq to answer fundamental questions about the mechanisms and consequences of gene expression evolution- especially in cases of evolutionary adaptations. The ideal candidate would have experience in yeast molecular biology techniques, as well as some familiarity with computational and/or evolutionary analysis. Salary and benefits are both above the NIH standards for postdocs. Please email a cover letter and CV to hbfraser[at]stanford[dot]edu.

Research Associate position (Ph.D. level) at Stanford University, March 2014

The Fraser Lab in the Department of Biology is seeking a Basic Life Science Research Associate (Ph.D. level). We apply the exciting tools of genomics and high-throughput sequencing to study the evolution of gene expression in a variety of species, but primarily budding yeast. Duties will include:

• Performing a wide range of experiments with the yeast S. cerevisiae. These will focus on a revolutionary new tool in molecular biology: genetic engineering via the CRISPR/Cas system. Other experiments will include gene knockout/replacement, chromatin immunoprecipitation, and high-throughput sequencing of mRNA. • Teaching experimental protocols to others in the lab • Keeping the lab's yeast strains/chemicals organized • Overseeing an undergraduate student for dishwashing/media preparation

A Ph.D. in a Biology-related field is required, with at least 2 years spent working with S. cerevisiae. Also desirable (but not required) is experience with: mammalian cell culture, chromatin immunoprecipitation, and/or high-throughput sequencing. Please email a cover letter and CV to hbfraser[at]stanford[dot]edu.

Postdoctoral fellowship in cell cycle evolution at the Institute of Genetics and Development of Rennes, France, January 2014

A three-year post-doctoral position supported by a starting grant from the European Research Council (ERC) is available in the group of Dr. Damien Coudreuse at the Institute of Genetics and Development of Rennes (IGDR), France (http://igdr.univ-rennes1.fr/english/). Research in this laboratory takes a synthetic biology approach in fission yeast to study the architecture and evolution of cell cycle regulation. The proposed project aims at understanding fundamental aspects of the evolution of cell proliferation, from how cells overcome external challenges to common features of independent evolutionary processes. It will be based on the use of fission yeast cells operating with various minimal cell cycle control circuits as starting points for experimental evolution approaches. Candidates should contact Dr. Damien Coudreuse at damien.coudreuse@univ-rennes1.fr and send a Curriculum Vitae, including past research experiences and publication records, as well as a letter detailing their motivation and interest in our work. Applicants should also request recommendation letters to be directly sent by two or three references.