Difference between revisions of "YOL086W-A"
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| − | '''Description of YOL086W-A:''' | + | '''Description of YOL086W-A:''' Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM, a Fanconi anemia complementation group protein, to stabilize and remodel blocked replication forks and repair damaged DNA; mhf1 srs2 double mutants are MMS hypersensitive; ortholog of human centromere constitutive-associated network (CCAN) subunit CENP-S, also known as MHF1<ref name='S000149670'>Schleiffer A, et al. (2012) CENP-T proteins are conserved centromere receptors of the Ndc80 complex. Nat Cell Biol 14(6):604-13 {{SGDpaper|S000149670}} PMID 22561346</ref><ref name='S000133636'>Yan Z, et al. (2010) A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability. Mol Cell 37(6):865-78 {{SGDpaper|S000133636}} PMID 20347428</ref><ref name='S000148403'>Yang H, et al. (2012) Saccharomyces Cerevisiae MHF Complex Structurally Resembles the Histones (H3-H4)(2) Heterotetramer and Functions as a Heterotetramer. Structure 20(2):364-70 |
{{SGDpaper|S000148403}} PMID 22325783</ref> | {{SGDpaper|S000148403}} PMID 22325783</ref> | ||
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Latest revision as of 13:05, 4 October 2012
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| Systematic name | YOL086W-A |
| Gene name | MHF1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XV:159173..159445 |
| Primary SGDID | S000007626 |
Description of YOL086W-A: Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM, a Fanconi anemia complementation group protein, to stabilize and remodel blocked replication forks and repair damaged DNA; mhf1 srs2 double mutants are MMS hypersensitive; ortholog of human centromere constitutive-associated network (CCAN) subunit CENP-S, also known as MHF1[1][2][3]
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References
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- ↑ Schleiffer A, et al. (2012) CENP-T proteins are conserved centromere receptors of the Ndc80 complex. Nat Cell Biol 14(6):604-13 SGD PMID 22561346
- ↑ Yan Z, et al. (2010) A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability. Mol Cell 37(6):865-78 SGD PMID 20347428
- ↑ Yang H, et al. (2012) Saccharomyces Cerevisiae MHF Complex Structurally Resembles the Histones (H3-H4)(2) Heterotetramer and Functions as a Heterotetramer. Structure 20(2):364-70 SGD PMID 22325783
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