Difference between revisions of "YOR269W"
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| − | '''Description of YOR269W:''' | + | '''Description of YOR269W:''' Involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; serves at interface between dynein's ATPase site and its microtubule binding stalk, causing individual dynein motors to remain attached to microtubules for long periods; synthetic lethal with bni1; homolog of human LIS1, mutations in which cause the severe brain disorder lissencephaly<ref name='S000048840'>Fujiwara T, et al. (1999) Bni1p regulates microtubule-dependent nuclear migration through the actin cytoskeleton in Saccharomyces cerevisiae. Mol Cell Biol 19(12):8016-27 {{SGDpaper|S000048840}} PMID 10567527</ref><ref name='S000150968'>Huang J, et al. (2012) Lis1 Acts as a Clutch between the ATPase and Microtubule-Binding Domains of the Dynein Motor. Cell 150(5):975-86 {{SGDpaper|S000150968}} PMID 22939623</ref><ref name='S000072477'>Lee WL, et al. (2003) The role of the lissencephaly protein Pac1 during nuclear migration in budding yeast. J Cell Biol 160(3):355-64 |
{{SGDpaper|S000072477}} PMID 12566428</ref> | {{SGDpaper|S000072477}} PMID 12566428</ref> | ||
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Latest revision as of 14:05, 18 September 2012
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| Systematic name | YOR269W |
| Gene name | PAC1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XV:826385..827869 |
| Primary SGDID | S000005795 |
Description of YOR269W: Involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; serves at interface between dynein's ATPase site and its microtubule binding stalk, causing individual dynein motors to remain attached to microtubules for long periods; synthetic lethal with bni1; homolog of human LIS1, mutations in which cause the severe brain disorder lissencephaly[1][2][3]
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References
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- ↑ Fujiwara T, et al. (1999) Bni1p regulates microtubule-dependent nuclear migration through the actin cytoskeleton in Saccharomyces cerevisiae. Mol Cell Biol 19(12):8016-27 SGD PMID 10567527
- ↑ Huang J, et al. (2012) Lis1 Acts as a Clutch between the ATPase and Microtubule-Binding Domains of the Dynein Motor. Cell 150(5):975-86 SGD PMID 22939623
- ↑ Lee WL, et al. (2003) The role of the lissencephaly protein Pac1 during nuclear migration in budding yeast. J Cell Biol 160(3):355-64 SGD PMID 12566428
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