Difference between revisions of "YBL005W"
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| − | '''Description of YBL005W:''' Transcriptional activator of the pleiotropic drug resistance network | + | '''Description of YBL005W:''' Transcriptional activator of the pleiotropic drug resistance network; regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements); post-translationally up-regulated in cells lacking a functional mitochondrial genome; PDR3 has a paralog, PDR1, that arose from the whole genome duplication<ref name='S000055982'>Balzi E and Goffeau A (1995) Yeast multidrug resistance: the PDR network. J Bioenerg Biomembr 27(1):71-6 {{SGDpaper|S000055982}} PMID 7629054</ref><ref name='S000113653'>Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61 {{SGDpaper|S000113653}} PMID 16169922</ref><ref name='S000048471'>Delaveau T, et al. (1994) PDR3, a new yeast regulatory gene, is homologous to PDR1 and controls the multidrug resistance phenomenon. Mol Gen Genet 244(5):501-11 {{SGDpaper|S000048471}} PMID 8078477</ref><ref name='S000069828'>Devaux F, et al. (2002) Genome-wide studies on the nuclear PDR3-controlled response to mitochondrial dysfunction in yeast. FEBS Lett 515(1-3):25-8 {{SGDpaper|S000069828}} PMID 11943188</ref><ref name='S000056021'>Kean LS, et al. (1997) Plasma membrane translocation of fluorescent-labeled phosphatidylethanolamine is controlled by transcription regulators, PDR1 and PDR3. J Cell Biol 138(2):255-70 {{SGDpaper|S000056021}} PMID 9230069</ref><ref name='S000046396'>Wolfger H, et al. (1997) The yeast ATP binding cassette (ABC) protein genes PDR10 and PDR15 are novel targets for the Pdr1 and Pdr3 transcriptional regulators. FEBS Lett 418(3):269-74 {{SGDpaper|S000046396}} PMID 9428726</ref><ref name='S000068775'>Zhang X and Moye-Rowley WS (2001) Saccharomyces cerevisiae multidrug resistance gene expression inversely correlates with the status of the F(0) component of the mitochondrial ATPase. J Biol Chem 276(51):47844-52 |
{{SGDpaper|S000068775}} PMID 11602584</ref> | {{SGDpaper|S000068775}} PMID 11602584</ref> | ||
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Latest revision as of 13:05, 31 August 2012
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| Systematic name | YBL005W |
| Gene name | PDR3 |
| Aliases | AMY2, TPE2 |
| Feature type | ORF, Verified |
| Coordinates | Chr II:217470..220400 |
| Primary SGDID | S000000101 |
Description of YBL005W: Transcriptional activator of the pleiotropic drug resistance network; regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements); post-translationally up-regulated in cells lacking a functional mitochondrial genome; PDR3 has a paralog, PDR1, that arose from the whole genome duplication[1][2][3][4][5][6][7]
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References
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- ↑ Balzi E and Goffeau A (1995) Yeast multidrug resistance: the PDR network. J Bioenerg Biomembr 27(1):71-6 SGD PMID 7629054
- ↑ Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61 SGD PMID 16169922
- ↑ Delaveau T, et al. (1994) PDR3, a new yeast regulatory gene, is homologous to PDR1 and controls the multidrug resistance phenomenon. Mol Gen Genet 244(5):501-11 SGD PMID 8078477
- ↑ Devaux F, et al. (2002) Genome-wide studies on the nuclear PDR3-controlled response to mitochondrial dysfunction in yeast. FEBS Lett 515(1-3):25-8 SGD PMID 11943188
- ↑ Kean LS, et al. (1997) Plasma membrane translocation of fluorescent-labeled phosphatidylethanolamine is controlled by transcription regulators, PDR1 and PDR3. J Cell Biol 138(2):255-70 SGD PMID 9230069
- ↑ Wolfger H, et al. (1997) The yeast ATP binding cassette (ABC) protein genes PDR10 and PDR15 are novel targets for the Pdr1 and Pdr3 transcriptional regulators. FEBS Lett 418(3):269-74 SGD PMID 9428726
- ↑ Zhang X and Moye-Rowley WS (2001) Saccharomyces cerevisiae multidrug resistance gene expression inversely correlates with the status of the F(0) component of the mitochondrial ATPase. J Biol Chem 276(51):47844-52 SGD PMID 11602584
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