Difference between revisions of "YDR346C"
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| + | Specifically higher expression in carbon limited chemostat cultures versus carbon excess. | ||
| + | <ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. | ||
| + | J Biol Chem 278(5):3265-74</ref> | ||
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Revision as of 12:02, 21 February 2007
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| Systematic name | YDR346C |
| Gene name | SVF1 |
| Aliases | SGI1 |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:1168653..1167208 |
Description of YDR346C: Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis[1]
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Contents
Community Commentary
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Alleles, Strains, and Phenotypes
Complete Deletion
Strain Background: W303
Phenotype(s): Loss of function (Null), Temperature(Heat) Sensitive
Mutant shows decreased growth in glycerol and decreased ability to undergo diauxic shift. These phenotypes are corrected by expression of Bcl-xL. (Conversely, YDR346C has anti-apoptotic activity when expressed in mammalian cells.) Authors have named the gene SVF1, and found homology only to other fungal genes. They suggest that SVF1 may represent an as yet unknown family of genes responsible for adaptation to cellular stress. [1] [2]
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References
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- ↑ 1.0 1.1 Vander Heiden MG, et al. (2002) Bcl-x(L) complements Saccharomyces cerevisiae genes that facilitate the switch from glycolytic to oxidative metabolism. J Biol Chem 277(47):44870-6
SGD PMID 12244097 Cite error: Invalid
<ref>tag; name "S000071715" defined multiple times with different content - ↑ submitted by Matthew Brauer on 2003-08-28
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