Difference between revisions of "YER169W"
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− | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000971 YER169W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''RPH1 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''RPH1 '' |
Latest revision as of 07:45, 23 January 2012
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Systematic name | YER169W |
Gene name | RPH1 |
Aliases | |
Feature type | ORF, Verified |
Coordinates | Chr V:523369..525759 |
Primary SGDID | S000000971 |
Description of YER169W: JmjC domain-containing histone demethylase; specifically demethylates H3K36 tri- and dimethyl modification states; associates with actively transcribed (RNA polymerase II) regions in vivo and specifically targets H3K36 in its trimethylation state as its substrate; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway[1][2][3][4][5]
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Contents
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References
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- ↑ Jang YK, et al. (1999) RPH1 and GIS1 are damage-responsive repressors of PHR1. Mol Cell Biol 19(11):7630-8 SGD PMID 10523651
- ↑ Kim EM, et al. (2002) Phosphorylation of Rph1, a damage-responsive repressor of PHR1 in Saccharomyces cerevisiae, is dependent upon Rad53 kinase. Nucleic Acids Res 30(3):643-8 SGD PMID 11809875
- ↑ Klose RJ, et al. (2007) Demethylation of histone H3K36 and H3K9 by Rph1: a vestige of an H3K9 methylation system in Saccharomyces cerevisiae? Mol Cell Biol 27(11):3951-61 SGD PMID 17371840
- ↑ Kwon DW and Ahn SH (2011) Role of yeast JmjC-domain containing histone demethylases in actively transcribed regions. Biochem Biophys Res Commun () SGD PMID 21684259
- ↑ Tu S, et al. (2007) Identification of histone demethylases in Saccharomyces cerevisiae. J Biol Chem 282(19):14262-71 SGD PMID 17369256
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