Difference between revisions of "YLR451W"
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| − | '''Description of YLR451W:''' Zinc- | + | '''Description of YLR451W:''' Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate, an intermediate in leucine biosynthesis that accumulates during leucine starvation<ref name='S000051008'>Friden P and Schimmel P (1987) LEU3 of Saccharomyces cerevisiae encodes a factor for control of RNA levels of a group of leucine-specific genes. Mol Cell Biol 7(8):2708-17 {{SGDpaper|S000051008}} PMID 2823102</ref><ref name='S000039652'>Friden P and Schimmel P (1988) LEU3 of Saccharomyces cerevisiae activates multiple genes for branched-chain amino acid biosynthesis by binding to a common decanucleotide core sequence. Mol Cell Biol 8(7):2690-7 {{SGDpaper|S000039652}} PMID 3043190</ref><ref name='S000055502'>Sze JY, et al. (1992) In vitro transcriptional activation by a metabolic intermediate: activation by Leu3 depends on alpha-isopropylmalate. Science 258(5085):1143-5 {{SGDpaper|S000055502}} PMID 1439822</ref><ref name='S000042858'>Zhou K, et al. (1987) Structure of yeast regulatory gene LEU3 and evidence that LEU3 itself is under general amino acid control. Nucleic Acids Res 15(13):5261-73 {{SGDpaper|S000042858}} PMID 3299266</ref><ref name='S000049861'>Zhou KM, et al. (1990) Yeast regulatory protein LEU3: a structure-function analysis. Nucleic Acids Res 18(2):291-8 |
| − | {{SGDpaper| | + | {{SGDpaper|S000049861}} PMID 2183176</ref> |
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Revision as of 14:05, 13 December 2011
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| Systematic name | YLR451W |
| Gene name | LEU3 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XII:1036093..1038753 |
| Primary SGDID | S000004443 |
Description of YLR451W: Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate, an intermediate in leucine biosynthesis that accumulates during leucine starvation[1][2][3][4][5]
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Contents
Community Commentary
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References
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- ↑ Friden P and Schimmel P (1987) LEU3 of Saccharomyces cerevisiae encodes a factor for control of RNA levels of a group of leucine-specific genes. Mol Cell Biol 7(8):2708-17 SGD PMID 2823102
- ↑ Friden P and Schimmel P (1988) LEU3 of Saccharomyces cerevisiae activates multiple genes for branched-chain amino acid biosynthesis by binding to a common decanucleotide core sequence. Mol Cell Biol 8(7):2690-7 SGD PMID 3043190
- ↑ Sze JY, et al. (1992) In vitro transcriptional activation by a metabolic intermediate: activation by Leu3 depends on alpha-isopropylmalate. Science 258(5085):1143-5 SGD PMID 1439822
- ↑ Zhou K, et al. (1987) Structure of yeast regulatory gene LEU3 and evidence that LEU3 itself is under general amino acid control. Nucleic Acids Res 15(13):5261-73 SGD PMID 3299266
- ↑ Zhou KM, et al. (1990) Yeast regulatory protein LEU3: a structure-function analysis. Nucleic Acids Res 18(2):291-8 SGD PMID 2183176
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