Positions in yeast labs

Yeast quantitative genetics post-doctoral positions at Duke University Medical Center

Positions are available for post-docs to work on a recently NIH funded grant “High throughput S. cerevisiae HAM, GWA & QT/QTL architecture resource”. Our understanding of quantitative traits, which includes pharmacogenetic variations in human drug efficacy and side effects, is poor. Improving our understanding of quantitative traits and of pharmacogenetics is aided by tractable model systems, such as Saccharomyces cerevisiae. In this study, we develop a novel S. cerevisiae genetic resource population for high throughput haploid association mapping (HAM) and genome wide association (GWA).

We will use the high quality genome sequences of 96 S. cerevisiae strains to generate a novel genetic resource population that we will use to perform high throughput determination of quantitative trait (QT) and quantitative trait loci (QTL) architecture. Start dates are open. Candidates should have recently received their Ph.D. (0 to – at most – 4 years) and should have expertise in yeast genetics/molecular biology and/or quantitative/population genetics. Candidates should email their curriculum vitae (pdf), including the names and contact information for three references, to John McCusker at mccus001@mc.duke.edu.

Institute of Genetics and Biotechnology, University of Warsaw, Poland

Positions for two (2) young (up to 4 years after doctorate) post-docs, three (3) Ph.D. students and two (2) M.Sc. students to work on the EU-funded project "Yeasts - an evolutionary laboratory for studying nucleo-mitochondrial interactions" to study the co-evolution of nuclear-encoded mitochondrial gene-expression factors and the mitochondrial genome in different yeast species, to analyze the mechanisms of mitochondrial RNA processing, and to propose yeast models for human mitochondrial disorders. For details see our website at [1]. Application deadline 13 June 2011.

Institute of Environmental Sciences at the Jagiellonian University, Kraków, Poland

The leading Polish institute in: Behavioral ecology, Evolutionary genetics and life histories, Physiological and bioenergetics, Ecotoxicology and industrial pollutants, Ecosystem ecology, environmental education and management Is opening applications for:

• 4-year interdisciplinary doctoral studies programme in ecology in English, with net-scholarships 2200 PLN per month, offering research in Poland and half-year placements in academic centres outside Poland and a choice of 4 out of 8 courses from different scientific disciplines conducted by eminent Polish and foreign specialists Application deadline: 10 June 2011
• 20-month fellowship programme for strongly motivated scientists with a PhD degree in Biology, Ecology or related field, with net-fellowship 3200 PLN per month plus social benefits, realized in one of the research groups at the Institute of Environmental Sciences and a monthly internship at the universities in Europe and the U.S. Application deadline: 29 April 2011

Detailed information, containing the description of research projects proposed for PhD students, profile of the applicant and the application instructions are available at: www.eko.uj.edu.pl/ecology

„Launching interdisciplinary doctoral studies programme in ecology in English and increasing the didactic potential of the staff of the Institute of Environmental Sciences at the Jagiellonian University” Project co-financed by the European Union under the European Social Fund

Postdoctoral positions for an ERC-funded project: Yeast chromatin/epigenetics - Nicosia, Cyprus - [2]

Positions for two (2) highly motivated Postdocs to work on the project ´Functional and regulatory protein networks of chromatin modifying enzymes´in the group of Dr Antonis Kirmizis (http://www.ucy.ac.cy/en-US/~kirmizis.aspx ). The post holders will elucidate novel epigenetic mechanisms in yeast using state-of-the-art genetic, proteomic, and genomic methods. The successful applicants should have a PhD Degree in molecular biology or related areas. Previous research experience in the field of chromatin and/or knowledge of yeast genetics and molecular biology will be considered an advantage. The positions are initially available for 2 years with the possibility to extend it to 5 years (subject to satisfactory progress). The starting gross salary for the position is €2,782 per month. The anticipated start date of the project is 03/01/2011 (this is negotiable). To apply, mail a cover letter, CV and contact details for at least 2 references to Human Resources Services, University of Cyprus, Anastasios G Leventis Building, P.O. Box 20537, 1678 Nicosia, Cyprus by 15 October 2010.

Multiple Postdoctoral Positions: University of Toronto / Harvard Medical School collaboration

Multiple postdoctoral positions are available within a collaboration led by faculty at either the Terrence Donnelly Centre for Cellular and Biomolecular Research or the Samuel Lunenfeld Research Institute together with Dr. Frederick Roth (Harvard Medical School, Dept of Biological Chemistry and Molecular Biology). Positions are in Toronto, ON but are collaborative and may initially require travel to Harvard Medical School in Boston, MA.

Postdoctoral Fellow – Pathway Genomics. Applicants should have substantial experience in molecular genetics and strong intellectual interest in systematic genetic approaches to characterize gene function, pathway order and drug mechanism. Potential projects include: 1) systematic measurement of synergistic drug combinations in human cell lines; 2) development of a deep sequencing approach for measuring genetic interactions; and 3) using deep sequencing to efficiently screen for kinase-dependent protein interactions.

Postdoctoral Fellow – Synthetic Biology. Applicants should have substantial experience in molecular genetics, and strong intellectual interest in the use of synthetic biology and genetic analysis to characterize gene function, pathway order, and drug mechanism. Potential projects include: a strategy for rapid production of strains in which many genes have been precisely re-engineered, in order to study multigenic genetic interactions and reconstruct pathways from human and other genetically recalcitrant systems; implementation of a physical genetic algorithm to optimize reconstructed or synthetic pathways. Potential applications include the study of drug resistance and metabolism or development of synthetic tools for large-scale genetic perturbation analysis.

Postdoctoral Fellow – Computational Genomics. Seeking a creative and talented postdoctoral fellow interested in using causal reasoning to reveal cellular pathways and drug mechanism of action via integration and analysis of large-scale genomic and proteomic experiments. Involves large-scale data from ongoing collaborations on protein interaction mapping, high-content cellular and organismal phenotyping, protein expression and metabolite profiling, and discovery of genetic interactions to identify and characterize biological pathways. Qualifications are a track record of imaginative quantitative research and a solid foundation in a substantial subset of computer science, mathematics, statistics, genetics and molecular biology.

To apply for any of these positions, please submit a curriculum vitae and contact information for three references to fritz_roth@hms.harvard.edu. http://llama.med.harvard.edu/positions.html

(posted April 23, 2010)