Difference between revisions of "YGR184C"

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==Community Commentary==
 
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==References==
 
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Revision as of 07:17, 30 January 2007

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Systematic name YGR184C
Gene name UBR1
Aliases PTR1
Feature type ORF, Verified
Coordinates Chr VII:865758..859906


Description of YGR184C: Ubiquitin-protein ligase (E3) that interacts with Rad6p/Ubc2p to ubiquitinate substrates of the N-end rule pathway; binds to the Rpn2p, Rpt1p, and Rpt6p proteins of the 19S particle of the 26S proteasome[1][2][3][4][5]




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Community Commentary

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References

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  1. Hochstrasser M (1996) Ubiquitin-dependent protein degradation. Annu Rev Genet 30():405-39 SGD PMID 8982460
  2. Xie Y and Varshavsky A (2000) Physical association of ubiquitin ligases and the 26S proteasome. Proc Natl Acad Sci U S A 97(6):2497-502 SGD PMID 10688918
  3. Sung P, et al. (1991) Yeast RAD6 encoded ubiquitin conjugating enzyme mediates protein degradation dependent on the N-end-recognizing E3 enzyme. EMBO J 10(8):2187-93 SGD PMID 2065660
  4. Bartel B, et al. (1990) The recognition component of the N-end rule pathway. EMBO J 9(10):3179-89 SGD PMID 2209542
  5. Dohmen RJ, et al. (1991) The N-end rule is mediated by the UBC2(RAD6) ubiquitin-conjugating enzyme. Proc Natl Acad Sci U S A 88(16):7351-5 SGD PMID 1651502

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