Difference between revisions of "YOR291W"
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| − | '''Description of YOR291W:''' Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor | + | '''Description of YOR291W:''' Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome<ref name='S000119132'>Catty P, et al. (1997) The complete inventory of the yeast Saccharomyces cerevisiae P-type transport ATPases. FEBS Lett 409(3):325-32 {{SGDpaper|S000119132}} PMID 9224683</ref><ref name='S000070157'>Cronin SR, et al. (2002) Cod1p/Spf1p is a P-type ATPase involved in ER function and Ca2+ homeostasis. J Cell Biol 157(6):1017-28 {{SGDpaper|S000070157}} PMID 12058017</ref><ref name='S000129215'>Gitler AD, et al. (2009) Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity. Nat Genet 41(3):308-15 {{SGDpaper|S000129215}} PMID 19182805</ref><ref name='S000129869'>Schmidt K, et al. (2009) Cd2+, Mn2+, Ni2+ and Se2+ toxicity to Saccharomyces cerevisiae lacking YPK9p the orthologue of human ATP13A2. Biochem Biophys Res Commun 383(2):198-202 |
{{SGDpaper|S000129869}} PMID 19345671</ref> | {{SGDpaper|S000129869}} PMID 19345671</ref> | ||
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Revision as of 14:05, 22 December 2010
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| Systematic name | YOR291W |
| Gene name | YPK9 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XV:861174..865592 |
| Primary SGDID | S000005817 |
Description of YOR291W: Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome[1][2][3][4]
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Contents
[hide]Community Commentary
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Alleles, Strains, and Phenotypes
Complete Deletion
Phenotype(s): No Phenotype, Viable
No obvious phenotypes were detected upon deletion of YOR291w with a KanMX deletion cassette. The deletion was confirmed by PCR. [5] [6]
Phenotype(s): No Phenotype, Viable
No obvious phenotypes were detected upon deletion of YOR291w with a KanMX deletion cassette. The deletion was confirmed by PCR. [5] [6]
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References
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- Jump up ↑ Catty P, et al. (1997) The complete inventory of the yeast Saccharomyces cerevisiae P-type transport ATPases. FEBS Lett 409(3):325-32 SGD PMID 9224683
- Jump up ↑ Cronin SR, et al. (2002) Cod1p/Spf1p is a P-type ATPase involved in ER function and Ca2+ homeostasis. J Cell Biol 157(6):1017-28 SGD PMID 12058017
- Jump up ↑ Gitler AD, et al. (2009) Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity. Nat Genet 41(3):308-15 SGD PMID 19182805
- Jump up ↑ Schmidt K, et al. (2009) Cd2+, Mn2+, Ni2+ and Se2+ toxicity to Saccharomyces cerevisiae lacking YPK9p the orthologue of human ATP13A2. Biochem Biophys Res Commun 383(2):198-202 SGD PMID 19345671
- ↑ Jump up to: 5.0 5.1 Cronin SR, et al. (2000) Regulation of HMG-CoA reductase degradation requires the P-type ATPase Cod1p/Spf1p. J Cell Biol 148(5):915-24 SGD PMID 10704442
- ↑ Jump up to: 6.0 6.1 submitted by Stephen R. Cronin on 2003-06-13
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