Difference between revisions of "YOR211C"
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| − | '''Description of YOR211C:''' Mitochondrial GTPase | + | '''Description of YOR211C:''' Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p; required for mt morphology and genome maintenance; exists as long and short form with different distributions; homolog of human OPA1 involved in autosomal dominant optic atrophy<ref name='S000058923'>Amutha B, et al. (2004) A novel role of Mgm1p, a dynamin-related GTPase, in ATP synthase assembly and cristae formation/maintenance. Biochem J 381(Pt 1):19-23 {{SGDpaper|S000058923}} PMID 15125685</ref><ref name='S000070154'>Olichon A, et al. (2002) The human dynamin-related protein OPA1 is anchored to the mitochondrial inner membrane facing the inter-membrane space. FEBS Lett 523(1-3):171-6 {{SGDpaper|S000070154}} PMID 12123827</ref><ref name='S000076835'>Sesaki H and Jensen RE (2004) Ugo1p links the Fzo1p and Mgm1p GTPases for mitochondrial fusion. J Biol Chem 279(27):28298-303 {{SGDpaper|S000076835}} PMID 15087460</ref><ref name='S000073565'>Sesaki H, et al. (2003) Mgm1p, a dynamin-related GTPase, is essential for fusion of the mitochondrial outer membrane. Mol Biol Cell 14(6):2342-56 {{SGDpaper|S000073565}} PMID 12808034</ref><ref name='S000059280'>Wong ED, et al. (2000) The dynamin-related GTPase, Mgm1p, is an intermembrane space protein required for maintenance of fusion competent mitochondria. J Cell Biol 151(2):341-52 {{SGDpaper|S000059280}} PMID 11038181</ref><ref name='S000135187'>Zick M, et al. (2009) Distinct roles of the two isoforms of the dynamin-like GTPase Mgm1 in mitochondrial fusion. FEBS Lett 583(13):2237-43 |
| − | {{SGDpaper| | + | {{SGDpaper|S000135187}} PMID 19505460</ref> |
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Revision as of 13:05, 2 December 2010
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| Systematic name | YOR211C |
| Gene name | MGM1 |
| Aliases | MNA1 |
| Feature type | ORF, Verified |
| Coordinates | Chr XV:741570..738925 |
| Primary SGDID | S000005737 |
Description of YOR211C: Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p; required for mt morphology and genome maintenance; exists as long and short form with different distributions; homolog of human OPA1 involved in autosomal dominant optic atrophy[1][2][3][4][5][6]
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Contents
Community Commentary
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Protein Details
Mature Length (direct evidence)
Protein length: 822 aa The N-terminus of the mature large isoform of Mgm1p starts at position 81 (ISHFPKII...; 822 aa). The N-terminus of the mature short isoform of Mgm1p starts at position 161 (ATLIAATS...; 742 aa) are alternatively at position 163 (LIAATS...; 740 aa). [7] [8]
Protein Function/Process
Both isoforms of Mgm1p are required for maintenance of mitochondrial morphology and of mitochondrial DNA. [7] [8]
Protein Localization
Large and short isoform are localized to the mitochondrial intermembrane space. The large isoform is anchored via a single N-terminal transmembrane segment to the mitochondrial inner membrane which is absent in the short isoform. [7] [8]
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References
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- ↑ Amutha B, et al. (2004) A novel role of Mgm1p, a dynamin-related GTPase, in ATP synthase assembly and cristae formation/maintenance. Biochem J 381(Pt 1):19-23 SGD PMID 15125685
- ↑ Olichon A, et al. (2002) The human dynamin-related protein OPA1 is anchored to the mitochondrial inner membrane facing the inter-membrane space. FEBS Lett 523(1-3):171-6 SGD PMID 12123827
- ↑ Sesaki H and Jensen RE (2004) Ugo1p links the Fzo1p and Mgm1p GTPases for mitochondrial fusion. J Biol Chem 279(27):28298-303 SGD PMID 15087460
- ↑ Sesaki H, et al. (2003) Mgm1p, a dynamin-related GTPase, is essential for fusion of the mitochondrial outer membrane. Mol Biol Cell 14(6):2342-56 SGD PMID 12808034
- ↑ Wong ED, et al. (2000) The dynamin-related GTPase, Mgm1p, is an intermembrane space protein required for maintenance of fusion competent mitochondria. J Cell Biol 151(2):341-52 SGD PMID 11038181
- ↑ Zick M, et al. (2009) Distinct roles of the two isoforms of the dynamin-like GTPase Mgm1 in mitochondrial fusion. FEBS Lett 583(13):2237-43 SGD PMID 19505460
- ↑ 7.0 7.1 7.2 Herlan M, et al. (2003) Processing of Mgm1 by the rhomboid-type protease Pcp1 is required for maintenance of mitochondrial morphology and of mitochondrial DNA. J Biol Chem 278(30):27781-8 SGD PMID 12707284
- ↑ 8.0 8.1 8.2 submitted by Andreas Reichert on 2003-09-25
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