Difference between revisions of "YPR104C"

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'''Description of YPR104C:''' Transcriptional activator with similarity to DNA-binding domain of Drosophila forkhead but unable to bind DNA in vitro; isolated as suppressor of RNA polymerase III mutant and of splicing factor prp4<ref name='S000044983'>Hermann-Le Denmat S, et al. (1994) Suppression of yeast RNA polymerase III mutations by FHL1, a gene coding for a fork head protein involved in rRNA processing. Mol Cell Biol 14(5):2905-13 {{SGDpaper|S000044983}} PMID 8164651</ref><ref name='S000054901'>Maddock JR, et al. (1994) Extragenic suppressors of Saccharomyces cerevisiae prp4 mutations identify a negative regulator of PRP genes. Genetics 136(3):833-47 {{SGDpaper|S000054901}} PMID 8005438</ref><ref name='S000080709'>Rudra D, et al. (2005) Central role of Ifh1p-Fhl1p interaction in the synthesis of yeast ribosomal proteins. EMBO J 24(3):533-42
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'''Description of YPR104C:''' Regulator of ribosomal protein transcription; has forkhead associated domain that binds phosphorylated proteins; also has forkhead DNA-binding domain but does not bind DNA in vitro; suppresses RNA pol III and splicing factor prp4 mutants<ref name='S000044983'>Hermann-Le Denmat S, et al. (1994) Suppression of yeast RNA polymerase III mutations by FHL1, a gene coding for a fork head protein involved in rRNA processing. Mol Cell Biol 14(5):2905-13 {{SGDpaper|S000044983}} PMID 8164651</ref><ref name='S000054901'>Maddock JR, et al. (1994) Extragenic suppressors of Saccharomyces cerevisiae prp4 mutations identify a negative regulator of PRP genes. Genetics 136(3):833-47 {{SGDpaper|S000054901}} PMID 8005438</ref><ref name='S000080709'>Rudra D, et al. (2005) Central role of Ifh1p-Fhl1p interaction in the synthesis of yeast ribosomal proteins. EMBO J 24(3):533-42 {{SGDpaper|S000080709}} PMID 15692568</ref><ref name='S000132106'>Xiao L and Grove A (2009) Coordination of Ribosomal Protein and Ribosomal RNA Gene Expression in Response to TOR Signaling. Curr Genomics 10(3):198-205
  {{SGDpaper|S000080709}} PMID 15692568</ref>
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  {{SGDpaper|S000132106}} PMID 19881913</ref>
 
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Revision as of 13:05, 1 March 2010

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Systematic name YPR104C
Gene name FHL1
Aliases SPP42
Feature type ORF, Verified
Coordinates Chr XVI:736431..733621
Primary SGDID S000006308


Description of YPR104C: Regulator of ribosomal protein transcription; has forkhead associated domain that binds phosphorylated proteins; also has forkhead DNA-binding domain but does not bind DNA in vitro; suppresses RNA pol III and splicing factor prp4 mutants[1][2][3][4]




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References

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  1. Hermann-Le Denmat S, et al. (1994) Suppression of yeast RNA polymerase III mutations by FHL1, a gene coding for a fork head protein involved in rRNA processing. Mol Cell Biol 14(5):2905-13 SGD PMID 8164651
  2. Maddock JR, et al. (1994) Extragenic suppressors of Saccharomyces cerevisiae prp4 mutations identify a negative regulator of PRP genes. Genetics 136(3):833-47 SGD PMID 8005438
  3. Rudra D, et al. (2005) Central role of Ifh1p-Fhl1p interaction in the synthesis of yeast ribosomal proteins. EMBO J 24(3):533-42 SGD PMID 15692568
  4. Xiao L and Grove A (2009) Coordination of Ribosomal Protein and Ribosomal RNA Gene Expression in Response to TOR Signaling. Curr Genomics 10(3):198-205 SGD PMID 19881913

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