Difference between revisions of "YDR138W"
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| − | '''Description of YDR138W:''' Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p | + | '''Description of YDR138W:''' Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p<ref name='S000047058'>Aguilera A and Klein HL (1990) HPR1, a novel yeast gene that prevents intrachromosomal excision recombination, shows carboxy-terminal homology to the Saccharomyces cerevisiae TOP1 gene. Mol Cell Biol 10(4):1439-51 {{SGDpaper|S000047058}} PMID 2181275</ref><ref name='S000114270'>Askree SH, et al. (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63 {{SGDpaper|S000114270}} PMID 15161972</ref><ref name='S000041293'>Chang M, et al. (1999) A complex containing RNA polymerase II, Paf1p, Cdc73p, Hpr1p, and Ccr4p plays a role in protein kinase C signaling. Mol Cell Biol 19(2):1056-67 {{SGDpaper|S000041293}} PMID 9891041</ref><ref name='S000063551'>Chavez S and Aguilera A (1997) The yeast HPR1 gene has a functional role in transcriptional elongation that uncovers a novel source of genome instability. Genes Dev 11(24):3459-70 {{SGDpaper|S000063551}} PMID 9407037</ref><ref name='S000059208'>Chavez S, et al. (2000) A protein complex containing Tho2, Hpr1, Mft1 and a novel protein, Thp2, connects transcription elongation with mitotic recombination in Saccharomyces cerevisiae. EMBO J 19(21):5824-34 {{SGDpaper|S000059208}} PMID 11060033</ref><ref name='S000066141'>Chavez S, et al. (2001) Hpr1 is preferentially required for transcription of either long or G+C-rich DNA sequences in Saccharomyces cerevisiae. Mol Cell Biol 21(20):7054-64 {{SGDpaper|S000066141}} PMID 11564888</ref><ref name='S000070300'>Jimeno S, et al. (2002) The yeast THO complex and mRNA export factors link RNA metabolism with transcription and genome instability. EMBO J 21(13):3526-35 {{SGDpaper|S000070300}} PMID 12093753</ref><ref name='S000069002'>Merker RJ and Klein HL (2002) hpr1Delta affects ribosomal DNA recombination and cell life span in Saccharomyces cerevisiae. Mol Cell Biol 22(2):421-9 |
| − | {{SGDpaper| | + | {{SGDpaper|S000069002}} PMID 11756539</ref> |
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Revision as of 13:05, 25 February 2010
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| Systematic name | YDR138W |
| Gene name | HPR1 |
| Aliases | TRF1 |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:730576..732834 |
| Primary SGDID | S000002545 |
Description of YDR138W: Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p[1][2][3][4][5][6][7][8]
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References
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- ↑ Aguilera A and Klein HL (1990) HPR1, a novel yeast gene that prevents intrachromosomal excision recombination, shows carboxy-terminal homology to the Saccharomyces cerevisiae TOP1 gene. Mol Cell Biol 10(4):1439-51 SGD PMID 2181275
- ↑ Askree SH, et al. (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63 SGD PMID 15161972
- ↑ Chang M, et al. (1999) A complex containing RNA polymerase II, Paf1p, Cdc73p, Hpr1p, and Ccr4p plays a role in protein kinase C signaling. Mol Cell Biol 19(2):1056-67 SGD PMID 9891041
- ↑ Chavez S and Aguilera A (1997) The yeast HPR1 gene has a functional role in transcriptional elongation that uncovers a novel source of genome instability. Genes Dev 11(24):3459-70 SGD PMID 9407037
- ↑ Chavez S, et al. (2000) A protein complex containing Tho2, Hpr1, Mft1 and a novel protein, Thp2, connects transcription elongation with mitotic recombination in Saccharomyces cerevisiae. EMBO J 19(21):5824-34 SGD PMID 11060033
- ↑ Chavez S, et al. (2001) Hpr1 is preferentially required for transcription of either long or G+C-rich DNA sequences in Saccharomyces cerevisiae. Mol Cell Biol 21(20):7054-64 SGD PMID 11564888
- ↑ Jimeno S, et al. (2002) The yeast THO complex and mRNA export factors link RNA metabolism with transcription and genome instability. EMBO J 21(13):3526-35 SGD PMID 12093753
- ↑ Merker RJ and Klein HL (2002) hpr1Delta affects ribosomal DNA recombination and cell life span in Saccharomyces cerevisiae. Mol Cell Biol 22(2):421-9 SGD PMID 11756539
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