Difference between revisions of "YOL025W"
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| − | '''Description of YOL025W:''' Protein involved in the determination of longevity and | + | '''Description of YOL025W:''' Protein involved in the determination of longevity and in the negative regulation of SCF E3-ubiquitin ligase function; preferentially expressed in young cells; overexpression extends replicative life span; similar to mammalian Cand1<ref name='S000055741'>Childress AM, et al. (1996) LAG2, a gene that determines yeast longevity. Microbiology 142 ( Pt 8):2289-97 {{SGDpaper|S000055741}} PMID 8760941</ref><ref name='S000131589'>Liu Y, et al. (2009) A longevity protein, Lag2, interacts with SCF complex and regulates SCF function. EMBO J 28(21):3366-77 {{SGDpaper|S000131589}} PMID 19763088</ref><ref name='S000132362'>Siergiejuk E, et al. (2009) Cullin neddylation and substrate-adaptors counteract SCF inhibition by the CAND1-like protein Lag2 in Saccharomyces cerevisiae. EMBO J 28(24):3845-56 |
| − | {{SGDpaper| | + | {{SGDpaper|S000132362}} PMID 19942853</ref> |
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Revision as of 13:05, 14 January 2010
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| Systematic name | YOL025W |
| Gene name | LAG2 |
| Aliases | ECM36 |
| Feature type | ORF, Verified |
| Coordinates | Chr XV:274958..276940 |
| Primary SGDID | S000005385 |
Description of YOL025W: Protein involved in the determination of longevity and in the negative regulation of SCF E3-ubiquitin ligase function; preferentially expressed in young cells; overexpression extends replicative life span; similar to mammalian Cand1[1][2][3]
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References
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- ↑ Childress AM, et al. (1996) LAG2, a gene that determines yeast longevity. Microbiology 142 ( Pt 8):2289-97 SGD PMID 8760941
- ↑ Liu Y, et al. (2009) A longevity protein, Lag2, interacts with SCF complex and regulates SCF function. EMBO J 28(21):3366-77 SGD PMID 19763088
- ↑ Siergiejuk E, et al. (2009) Cullin neddylation and substrate-adaptors counteract SCF inhibition by the CAND1-like protein Lag2 in Saccharomyces cerevisiae. EMBO J 28(24):3845-56 SGD PMID 19942853
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