Difference between revisions of "YKR089C"
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| + | === Alleles, Strains, and Phenotypes === | ||
| + | [[Category:Topic:Alleles, Strains, and Phenotypes]] | ||
| + | ==== Multiple Knockout Strains ==== | ||
| + | [[Category:Topic:Alleles, Strains, and Phenotypes:Multiple Knockout Strains]] | ||
| + | '''Together with''': TGL3<br> | ||
| + | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]], Recessive [[Category:Phenotype:Recessive]], Viable [[Category:Phenotype:Viable]] | ||
| + | tgl3 tgl4 double mutants are unable to degrade triglycerides in lag and early log-phases of growth <ref name='S000087074'>Kurat CF, et al. (2006) Obese yeast: triglyceride lipolysis is functionally conserved from mammals to yeast. J Biol Chem 281(1):491-500 {{SGDpaper|S000087074}} PMID 16267052</ref> <ref name = 'CAset3132-2006-05-22'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=3132 Sepp D. Kohlwein] on 2006-05-22</ref> | ||
| + | |||
| + | {{ShortCenteredHR}} | ||
| + | === Protein Details === | ||
| + | [[Category:Topic:Protein Details]] | ||
| + | ==== Protein Function/Process ==== | ||
| + | [[Category:Topic:Protein Details:Protein Function/Process]] | ||
| + | '''Together with''': TGL3<br> | ||
| + | |||
| + | Triglyceride lipase activity; Functional complementation of tgl4 mutants by murine ATGL, Adipose Triglyceride Lipase <ref name='S000087074'>Kurat CF, et al. (2006) Obese yeast: triglyceride lipolysis is functionally conserved from mammals to yeast. J Biol Chem 281(1):491-500 {{SGDpaper|S000087074}} PMID 16267052</ref> <ref name = 'CAset3132-2006-05-22'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=3132 Sepp D. Kohlwein] on 2006-05-22</ref> | ||
| + | |||
| + | {{ShortCenteredHR}} | ||
| + | ==== Protein Modification ==== | ||
| + | [[Category:Topic:Protein Details:Protein Modification]] | ||
| + | '''Modification(s)''': Phosphorylation [[Category:Modification:Phosphorylation]] | ||
| + | |||
| + | Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. <ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 {{SGDpaper|S000074306}} PMID 14574415</ref> <ref name = 'CAset7903-2004-01-29'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=7903 Jeff Ubersax] on 2004-01-29</ref> | ||
| + | |||
| + | {{ShortCenteredHR}} | ||
__TOC__ | __TOC__ | ||
==Community Commentary== | ==Community Commentary== | ||
{{CommentaryHelp}} | {{CommentaryHelp}} | ||
| + | === Alleles, Strains, and Phenotypes === | ||
| + | [[Category:Topic:Alleles, Strains, and Phenotypes]] | ||
| + | ==== Multiple Knockout Strains ==== | ||
| + | [[Category:Topic:Alleles, Strains, and Phenotypes:Multiple Knockout Strains]] | ||
| + | '''Together with''': TGL3<br> | ||
| + | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]], Recessive [[Category:Phenotype:Recessive]], Viable [[Category:Phenotype:Viable]] | ||
| + | |||
| + | tgl3 tgl4 double mutants are unable to degrade triglycerides in lag and early log-phases of growth <ref name='S000087074'>Kurat CF, et al. (2006) Obese yeast: triglyceride lipolysis is functionally conserved from mammals to yeast. J Biol Chem 281(1):491-500 {{SGDpaper|S000087074}} PMID 16267052</ref> <ref name = 'CAset3132-2006-05-22'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=3132 Sepp D. Kohlwein] on 2006-05-22</ref> | ||
| + | |||
| + | {{ShortCenteredHR}} | ||
| + | === Protein Details === | ||
| + | [[Category:Topic:Protein Details]] | ||
| + | ==== Protein Function/Process ==== | ||
| + | [[Category:Topic:Protein Details:Protein Function/Process]] | ||
| + | '''Together with''': TGL3<br> | ||
| + | |||
| + | Triglyceride lipase activity; Functional complementation of tgl4 mutants by murine ATGL, Adipose Triglyceride Lipase <ref name='S000087074'>Kurat CF, et al. (2006) Obese yeast: triglyceride lipolysis is functionally conserved from mammals to yeast. J Biol Chem 281(1):491-500 {{SGDpaper|S000087074}} PMID 16267052</ref> <ref name = 'CAset3132-2006-05-22'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=3132 Sepp D. Kohlwein] on 2006-05-22</ref> | ||
| + | |||
| + | {{ShortCenteredHR}} | ||
| + | ==== Protein Modification ==== | ||
| + | [[Category:Topic:Protein Details:Protein Modification]] | ||
| + | '''Modification(s)''': Phosphorylation [[Category:Modification:Phosphorylation]] | ||
| + | |||
| + | Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. <ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 {{SGDpaper|S000074306}} PMID 14574415</ref> <ref name = 'CAset7903-2004-01-29'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=7903 Jeff Ubersax] on 2004-01-29</ref> | ||
| + | {{ShortCenteredHR}} | ||
==References== | ==References== | ||
<!-- REFERENCES ARE AUTOMATICALLY GENERATED. PLEASE DON'T EDIT THIS SECTION--> | <!-- REFERENCES ARE AUTOMATICALLY GENERATED. PLEASE DON'T EDIT THIS SECTION--> | ||
{{RefHelp}} | {{RefHelp}} | ||
Revision as of 16:05, 23 January 2007
Share your knowledge...Edit this entry!
| Systematic name | YKR089C | |
| Gene name | TGL4 | |
| Aliases | STC1 | |
| Feature type | ORF, Verified | |
| Coordinates | Chr XI:608007..605275 | |
| Don't edit this box! It's automatically regenerated, and edits will be lost when the update script runs. | ||
Description of YKR089C: Triacylglycerol lipase involved in triacylglycerol mobilization and degradation; found in lipid particles; potential Cdc28p substrate[1][2][3]
Alleles, Strains, and Phenotypes
Multiple Knockout Strains
Together with: TGL3
Phenotype(s): Loss of function (Null), Recessive, Viable
tgl3 tgl4 double mutants are unable to degrade triglycerides in lag and early log-phases of growth [1] [4]
Protein Details
Protein Function/Process
Together with: TGL3
Triglyceride lipase activity; Functional complementation of tgl4 mutants by murine ATGL, Adipose Triglyceride Lipase [1] [4]
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [3] [5]
Community Commentary
About Community Commentary. Please share your knowledge!
Alleles, Strains, and Phenotypes
Multiple Knockout Strains
Together with: TGL3
Phenotype(s): Loss of function (Null), Recessive, Viable
tgl3 tgl4 double mutants are unable to degrade triglycerides in lag and early log-phases of growth [1] [4]
Protein Details
Protein Function/Process
Together with: TGL3
Triglyceride lipase activity; Functional complementation of tgl4 mutants by murine ATGL, Adipose Triglyceride Lipase [1] [4]
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [3] [5]
References
See Help:References on how to add references
- ↑ 1.0 1.1 1.2 1.3 1.4 Kurat CF, et al. (2006) Obese yeast: triglyceride lipolysis is functionally conserved from mammals to yeast. J Biol Chem 281(1):491-500 SGD PMID 16267052
- ↑ Athenstaedt K and Daum G (2005) Tgl4p and Tgl5p, two triacylglycerol lipases of the yeast Saccharomyces cerevisiae are localized to lipid particles. J Biol Chem 280(45):37301-9 SGD PMID 16135509
- ↑ 3.0 3.1 3.2 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
SGD PMID 14574415 Cite error: Invalid
<ref>tag; name "S000074306" defined multiple times with different content Cite error: Invalid<ref>tag; name "S000074306" defined multiple times with different content - ↑ 4.0 4.1 4.2 4.3 submitted by Sepp D. Kohlwein on 2006-05-22
- ↑ 5.0 5.1 submitted by Jeff Ubersax on 2004-01-29
See Help:Categories on how to add the wiki page for this gene to a Category
Categories:
- Pages with reference errors
- ORF
- ORF, Verified
- Topic:Alleles, Strains, and Phenotypes
- Topic:Alleles, Strains, and Phenotypes:Multiple Knockout Strains
- Phenotype:Loss of function (Null)
- Phenotype:Recessive
- Phenotype:Viable
- Topic:Protein Details
- Topic:Protein Details:Protein Function/Process
- Topic:Protein Details:Protein Modification
- Modification:Phosphorylation
