Difference between revisions of "YGL208W"

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=== Alleles, Strains, and Phenotypes ===
 +
[[Category:Topic:Alleles, Strains, and Phenotypes]]
 +
==== Multiple Knockout Strains ====
 +
[[Category:Topic:Alleles, Strains, and Phenotypes:Multiple Knockout Strains]]
  
 +
'''Strain Background''': Sigma1278b (Sigma2000 series)<br>
 +
'''Genotype''': MCY 4597<br>
 +
'''Together with''': NRG2, NRG1, SIP1, GAL83<br>
 +
'''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]]
 +
 +
sip2 gal83 double mutants are more defective for invasive growth in response to limiting glucose than gal83 single mutants. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref>
 +
 +
{{ShortCenteredHR}}
 +
 +
'''Strain Background''': Sigma1278b (Sigma2000 series)<br>
 +
'''Genotype''': MCY4600<br>
 +
'''Together with''': REG1, SIP1, GAL83, MUC1<br>
 +
'''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]]
 +
 +
Deletion of SIP1 in a gal83 sip2 double mutant causes an increase in invasion, suggesting Sip1 negatively regulates invasive growth. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref>
 +
 +
{{ShortCenteredHR}}
 +
 +
'''Strain Background''': Sigma1278b (Sigma 2000 series)<br>
 +
'''Genotype''': MCY4633<br>
 +
'''Together with''': REG1, SIP1, GAL83, MUC1<br>
 +
'''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]]
 +
 +
Deletion of both SIP2 and GAL83 in a reg1 mutant suppresses its constitutive filamentous phenotype. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref>
 +
 +
{{ShortCenteredHR}}
 +
 +
'''Strain Background''': Sigma1278b (Sigma2000 series)<br>
 +
'''Genotype''': MCY4600<br>
 +
'''Together with''': REG1, SIP1, GAL83, MUC1<br>
 +
'''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]]
 +
 +
Deletion of SIP1 in a gal83 sip2 double mutant causes an increase in invasion, suggesting Sip1 negatively regulates invasive growth. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref>
 +
 +
{{ShortCenteredHR}}
 +
 +
'''Strain Background''': Sigma1278b (Sigma 2000 series)<br>
 +
'''Genotype''': MCY4597<br>
 +
'''Together with''': NRG2, NRG1, SIP1, GAL83<br>
 +
'''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]]
 +
 +
sip2 gal83 double mutants are defective for filamentation in response to glucose depletion. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref>
 +
 +
{{ShortCenteredHR}}
 +
 +
'''Strain Background''': Sigma1278b (Sigma2000 series)<br>
 +
'''Genotype''': MCY 4597<br>
 +
'''Together with''': NRG2, NRG1, SIP1, GAL83<br>
 +
'''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]]
 +
 +
sip2 gal83 double mutants are more defective for invasive growth in response to limiting glucose than gal83 single mutants. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref>
 +
 +
{{ShortCenteredHR}}
 +
 +
'''Strain Background''': Sigma1278b (Sigma 2000 series)<br>
 +
'''Genotype''': MCY4633<br>
 +
'''Together with''': REG1, SIP1, GAL83, MUC1<br>
 +
'''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]]
 +
 +
Deletion of both SIP2 and GAL83 in a reg1 mutant suppresses its constitutive filamentous phenotype. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref>
 +
 +
{{ShortCenteredHR}}
 +
 +
'''Strain Background''': Sigma1278b (Sigma 2000 series)<br>
 +
'''Genotype''': MCY4597<br>
 +
'''Together with''': NRG2, NRG1, SIP1, GAL83<br>
 +
'''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]]
 +
 +
sip2 gal83 double mutants are defective for filamentation in response to glucose depletion. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref>
 +
 +
{{ShortCenteredHR}}
 +
=== DNA and RNA Details ===
 +
[[Category:Topic:DNA and RNA Details]]
 +
==== Other DNA and RNA Details ====
 +
[[Category:Topic:DNA and RNA Details:Other DNA and RNA Details]]
 +
'''Other Topic''': expression [[Category:Topic:expression]]
 +
 +
Specifically higher expression in carbon limited chemostat cultures versus carbon excess. <ref name='S000073646'>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. J Biol Chem 278(5):3265-74 {{SGDpaper|S000073646}} PMID 12414795</ref> <ref name = 'CAset9153-2003-07-25'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9153 Viktor Boer] on 2003-07-25</ref>
 +
 +
{{ShortCenteredHR}}
 +
=== Protein Details ===
 +
[[Category:Topic:Protein Details]]
 +
==== Protein Function/Process ====
 +
[[Category:Topic:Protein Details:Protein Function/Process]]
 +
 +
One of three alternative beta subunits of the Snf1 kinase complex <ref name='S000059161'>Schmidt MC and McCartney RR (2000) beta-subunits of Snf1 kinase are required for kinase function and substrate definition. EMBO J 19(18):4936-43 {{SGDpaper|S000059161}} PMID 10990457</ref> <ref name = 'CAset5180-2003-02-17'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=5180 Martin C. Schmidt] on 2003-02-17</ref>
 +
 +
{{ShortCenteredHR}}
 
__TOC__
 
__TOC__
 
==Community Commentary==
 
==Community Commentary==
 
{{CommentaryHelp}}
 
{{CommentaryHelp}}
 +
=== Alleles, Strains, and Phenotypes ===
 +
[[Category:Topic:Alleles, Strains, and Phenotypes]]
 +
==== Multiple Knockout Strains ====
 +
[[Category:Topic:Alleles, Strains, and Phenotypes:Multiple Knockout Strains]]
 +
 +
'''Strain Background''': Sigma1278b (Sigma2000 series)<br>
 +
'''Genotype''': MCY 4597<br>
 +
'''Together with''': NRG2, NRG1, SIP1, GAL83<br>
 +
'''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]]
 +
 +
sip2 gal83 double mutants are more defective for invasive growth in response to limiting glucose than gal83 single mutants. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref>
 +
 +
{{ShortCenteredHR}}
 +
 +
'''Strain Background''': Sigma1278b (Sigma2000 series)<br>
 +
'''Genotype''': MCY4600<br>
 +
'''Together with''': REG1, SIP1, GAL83, MUC1<br>
 +
'''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]]
 +
 +
Deletion of SIP1 in a gal83 sip2 double mutant causes an increase in invasion, suggesting Sip1 negatively regulates invasive growth. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref>
 +
 +
{{ShortCenteredHR}}
 +
 +
'''Strain Background''': Sigma1278b (Sigma 2000 series)<br>
 +
'''Genotype''': MCY4633<br>
 +
'''Together with''': REG1, SIP1, GAL83, MUC1<br>
 +
'''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]]
 +
 +
Deletion of both SIP2 and GAL83 in a reg1 mutant suppresses its constitutive filamentous phenotype. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref>
 +
 +
{{ShortCenteredHR}}
 +
 +
'''Strain Background''': Sigma1278b (Sigma2000 series)<br>
 +
'''Genotype''': MCY4600<br>
 +
'''Together with''': REG1, SIP1, GAL83, MUC1<br>
 +
'''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]]
 +
 +
Deletion of SIP1 in a gal83 sip2 double mutant causes an increase in invasion, suggesting Sip1 negatively regulates invasive growth. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref>
 +
 +
{{ShortCenteredHR}}
 +
 +
'''Strain Background''': Sigma1278b (Sigma 2000 series)<br>
 +
'''Genotype''': MCY4597<br>
 +
'''Together with''': NRG2, NRG1, SIP1, GAL83<br>
 +
'''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]]
 +
 +
sip2 gal83 double mutants are defective for filamentation in response to glucose depletion. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref>
 +
 +
{{ShortCenteredHR}}
 +
 +
'''Strain Background''': Sigma1278b (Sigma2000 series)<br>
 +
'''Genotype''': MCY 4597<br>
 +
'''Together with''': NRG2, NRG1, SIP1, GAL83<br>
 +
'''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]]
 +
 +
sip2 gal83 double mutants are more defective for invasive growth in response to limiting glucose than gal83 single mutants. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref>
 +
 +
{{ShortCenteredHR}}
 +
 +
'''Strain Background''': Sigma1278b (Sigma 2000 series)<br>
 +
'''Genotype''': MCY4633<br>
 +
'''Together with''': REG1, SIP1, GAL83, MUC1<br>
 +
'''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]]
 +
 +
Deletion of both SIP2 and GAL83 in a reg1 mutant suppresses its constitutive filamentous phenotype. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref>
 +
 +
{{ShortCenteredHR}}
 +
 +
'''Strain Background''': Sigma1278b (Sigma 2000 series)<br>
 +
'''Genotype''': MCY4597<br>
 +
'''Together with''': NRG2, NRG1, SIP1, GAL83<br>
 +
'''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]]
 +
 +
sip2 gal83 double mutants are defective for filamentation in response to glucose depletion. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref>
 +
 +
{{ShortCenteredHR}}
 +
=== DNA and RNA Details ===
 +
[[Category:Topic:DNA and RNA Details]]
 +
==== Other DNA and RNA Details ====
 +
[[Category:Topic:DNA and RNA Details:Other DNA and RNA Details]]
 +
'''Other Topic''': expression [[Category:Topic:expression]]
 +
 +
Specifically higher expression in carbon limited chemostat cultures versus carbon excess. <ref name='S000073646'>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. J Biol Chem 278(5):3265-74 {{SGDpaper|S000073646}} PMID 12414795</ref> <ref name = 'CAset9153-2003-07-25'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9153 Viktor Boer] on 2003-07-25</ref>
 +
 +
{{ShortCenteredHR}}
 +
=== Protein Details ===
 +
[[Category:Topic:Protein Details]]
 +
==== Protein Function/Process ====
 +
[[Category:Topic:Protein Details:Protein Function/Process]]
 +
 +
One of three alternative beta subunits of the Snf1 kinase complex <ref name='S000059161'>Schmidt MC and McCartney RR (2000) beta-subunits of Snf1 kinase are required for kinase function and substrate definition. EMBO J 19(18):4936-43 {{SGDpaper|S000059161}} PMID 10990457</ref> <ref name = 'CAset5180-2003-02-17'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=5180 Martin C. Schmidt] on 2003-02-17</ref>
  
 +
{{ShortCenteredHR}}
 
==References==
 
==References==
 
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Revision as of 16:05, 23 January 2007

Share your knowledge...Edit this entry!

Systematic name YGL208W
Gene name SIP2
Aliases SPM2
Feature type ORF, Verified
Coordinates Chr VII:97342..98589
Don't edit this box! It's automatically regenerated, and edits will be lost when the update script runs.


Description of YGL208W: One of three beta subunits of the Snf1 serine/threonine protein kinase complex involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane[1][2][3][4]



Alleles, Strains, and Phenotypes

Multiple Knockout Strains

Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY 4597
Together with: NRG2, NRG1, SIP1, GAL83
Phenotype(s): Loss of function (Null)

sip2 gal83 double mutants are more defective for invasive growth in response to limiting glucose than gal83 single mutants. [5] [6]

Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4600
Together with: REG1, SIP1, GAL83, MUC1
Phenotype(s): Loss of function (Null)

Deletion of SIP1 in a gal83 sip2 double mutant causes an increase in invasion, suggesting Sip1 negatively regulates invasive growth. [5] [6]

Strain Background: Sigma1278b (Sigma 2000 series)
Genotype: MCY4633
Together with: REG1, SIP1, GAL83, MUC1
Phenotype(s): Loss of function (Null)

Deletion of both SIP2 and GAL83 in a reg1 mutant suppresses its constitutive filamentous phenotype. [5] [6]

Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4600
Together with: REG1, SIP1, GAL83, MUC1
Phenotype(s): Loss of function (Null)

Deletion of SIP1 in a gal83 sip2 double mutant causes an increase in invasion, suggesting Sip1 negatively regulates invasive growth. [5] [6]

Strain Background: Sigma1278b (Sigma 2000 series)
Genotype: MCY4597
Together with: NRG2, NRG1, SIP1, GAL83
Phenotype(s): Loss of function (Null)

sip2 gal83 double mutants are defective for filamentation in response to glucose depletion. [5] [6]

Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY 4597
Together with: NRG2, NRG1, SIP1, GAL83
Phenotype(s): Loss of function (Null)

sip2 gal83 double mutants are more defective for invasive growth in response to limiting glucose than gal83 single mutants. [5] [6]

Strain Background: Sigma1278b (Sigma 2000 series)
Genotype: MCY4633
Together with: REG1, SIP1, GAL83, MUC1
Phenotype(s): Loss of function (Null)

Deletion of both SIP2 and GAL83 in a reg1 mutant suppresses its constitutive filamentous phenotype. [5] [6]

Strain Background: Sigma1278b (Sigma 2000 series)
Genotype: MCY4597
Together with: NRG2, NRG1, SIP1, GAL83
Phenotype(s): Loss of function (Null)

sip2 gal83 double mutants are defective for filamentation in response to glucose depletion. [5] [6]

DNA and RNA Details

Other DNA and RNA Details

Other Topic: expression

Specifically higher expression in carbon limited chemostat cultures versus carbon excess. [7] [8]

Protein Details

Protein Function/Process

One of three alternative beta subunits of the Snf1 kinase complex [3] [9]

Community Commentary

About Community Commentary. Please share your knowledge!

Alleles, Strains, and Phenotypes

Multiple Knockout Strains

Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY 4597
Together with: NRG2, NRG1, SIP1, GAL83
Phenotype(s): Loss of function (Null)

sip2 gal83 double mutants are more defective for invasive growth in response to limiting glucose than gal83 single mutants. [5] [6]

Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4600
Together with: REG1, SIP1, GAL83, MUC1
Phenotype(s): Loss of function (Null)

Deletion of SIP1 in a gal83 sip2 double mutant causes an increase in invasion, suggesting Sip1 negatively regulates invasive growth. [5] [6]

Strain Background: Sigma1278b (Sigma 2000 series)
Genotype: MCY4633
Together with: REG1, SIP1, GAL83, MUC1
Phenotype(s): Loss of function (Null)

Deletion of both SIP2 and GAL83 in a reg1 mutant suppresses its constitutive filamentous phenotype. [5] [6]

Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4600
Together with: REG1, SIP1, GAL83, MUC1
Phenotype(s): Loss of function (Null)

Deletion of SIP1 in a gal83 sip2 double mutant causes an increase in invasion, suggesting Sip1 negatively regulates invasive growth. [5] [6]

Strain Background: Sigma1278b (Sigma 2000 series)
Genotype: MCY4597
Together with: NRG2, NRG1, SIP1, GAL83
Phenotype(s): Loss of function (Null)

sip2 gal83 double mutants are defective for filamentation in response to glucose depletion. [5] [6]

Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY 4597
Together with: NRG2, NRG1, SIP1, GAL83
Phenotype(s): Loss of function (Null)

sip2 gal83 double mutants are more defective for invasive growth in response to limiting glucose than gal83 single mutants. [5] [6]

Strain Background: Sigma1278b (Sigma 2000 series)
Genotype: MCY4633
Together with: REG1, SIP1, GAL83, MUC1
Phenotype(s): Loss of function (Null)

Deletion of both SIP2 and GAL83 in a reg1 mutant suppresses its constitutive filamentous phenotype. [5] [6]

Strain Background: Sigma1278b (Sigma 2000 series)
Genotype: MCY4597
Together with: NRG2, NRG1, SIP1, GAL83
Phenotype(s): Loss of function (Null)

sip2 gal83 double mutants are defective for filamentation in response to glucose depletion. [5] [6]

DNA and RNA Details

Other DNA and RNA Details

Other Topic: expression

Specifically higher expression in carbon limited chemostat cultures versus carbon excess. [7] [8]

Protein Details

Protein Function/Process

One of three alternative beta subunits of the Snf1 kinase complex [3] [9]

References

See Help:References on how to add references

  1. ↑ Lin SS, et al. (2003) Sip2, an N-myristoylated beta subunit of Snf1 kinase, regulates aging in Saccharomyces cerevisiae by affecting cellular histone kinase activity, recombination at rDNA loci, and silencing. J Biol Chem 278(15):13390-7 SGD PMID 12562756
  2. ↑ Vincent O, et al. (2001) Subcellular localization of the Snf1 kinase is regulated by specific beta subunits and a novel glucose signaling mechanism. Genes Dev 15(9):1104-14 SGD PMID 11331606
  3. ↑ 3.0 3.1 3.2 Schmidt MC and McCartney RR (2000) beta-subunits of Snf1 kinase are required for kinase function and substrate definition. EMBO J 19(18):4936-43 SGD PMID 10990457
  4. ↑ Ashrafi K, et al. (2000) Sip2p and its partner snf1p kinase affect aging in S. cerevisiae. Genes Dev 14(15):1872-85 SGD PMID 10921902
  5. ↑ 5.00 5.01 5.02 5.03 5.04 5.05 5.06 5.07 5.08 5.09 5.10 5.11 5.12 5.13 5.14 5.15 Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 SGD PMID 12556493
  6. ↑ 6.00 6.01 6.02 6.03 6.04 6.05 6.06 6.07 6.08 6.09 6.10 6.11 6.12 6.13 6.14 6.15 submitted by Valmik K. Vyas on 2003-03-27
  7. ↑ 7.0 7.1 Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. J Biol Chem 278(5):3265-74 SGD PMID 12414795
  8. ↑ 8.0 8.1 submitted by Viktor Boer on 2003-07-25
  9. ↑ 9.0 9.1 submitted by Martin C. Schmidt on 2003-02-17

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