Difference between revisions of "YER041W"
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| − | '''Description of YER041W:''' Holliday junction resolvase; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p | + | '''Description of YER041W:''' Holliday junction resolvase; localization is cell-cycle dependant and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p<ref name='S000051194'>Johnson RE, et al. (1998) Role of yeast Rth1 nuclease and its homologs in mutation avoidance, DNA repair, and DNA replication. Curr Genet 34(1):21-9 {{SGDpaper|S000051194}} PMID 9683672</ref><ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 {{SGDpaper|S000074306}} PMID 14574415</ref><ref name='S000128360'>Ip SC, et al. (2008) Identification of Holliday junction resolvases from humans and yeast. Nature 456(7220):357-361 {{SGDpaper|S000128360}} PMID 19020614</ref><ref name='S000130607'>Kosugi S, et al. (2009) Systematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifs. Proc Natl Acad Sci U S A |
| − | {{SGDpaper| | + | {{SGDpaper|S000130607}} PMID 19520826</ref> |
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Revision as of 13:05, 22 June 2009
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| Systematic name | YER041W |
| Gene name | YEN1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr V:232460..234739 |
| Primary SGDID | S000000843 |
Description of YER041W: Holliday junction resolvase; localization is cell-cycle dependant and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p[1][2][3][4]
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Protein Details
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [2] [5]
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References
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- ↑ Johnson RE, et al. (1998) Role of yeast Rth1 nuclease and its homologs in mutation avoidance, DNA repair, and DNA replication. Curr Genet 34(1):21-9 SGD PMID 9683672
- ↑ 2.0 2.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
- ↑ Ip SC, et al. (2008) Identification of Holliday junction resolvases from humans and yeast. Nature 456(7220):357-361 SGD PMID 19020614
- ↑ Kosugi S, et al. (2009) Systematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifs. Proc Natl Acad Sci U S A SGD PMID 19520826
- ↑ submitted by Jeff Ubersax on 2004-01-27
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