Difference between revisions of "YHL007C"

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'''Description of YHL007C:''' Signal transducing kinase of the PAK (p21-activated kinase) family, involved in pheromone response and pseudohyphal/invasive growth pathways, activated by Cdc42p; binds Ste4p at a GBB motif present in noncatalytic domains of PAK kinases<ref name='S000044194'>Peter M, et al. (1996) Functional analysis of the interaction between the small GTP binding protein Cdc42 and the Ste20 protein kinase in yeast. EMBO J 15(24):7046-59 {{SGDpaper|S000044194}} PMID 9003780</ref><ref name='S000066166'>Song J, et al. (2001) Molecular interactions of the Gbeta binding domain of the Ste20p/PAK family of protein kinases. An isolated but fully functional Gbeta binding domain from Ste20p is only partially folded as shown by heteronuclear NMR spectroscopy. J Biol Chem 276(44):41205-12
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'''Description of YHL007C:''' Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, involved in pheromone response, pseudohyphal/invasive growth, and vacuole inheritance; GBB motif (found in noncatalytic domains of PAKs) binds Ste4p<ref name='S000044194'>Peter M, et al. (1996) Functional analysis of the interaction between the small GTP binding protein Cdc42 and the Ste20 protein kinase in yeast. EMBO J 15(24):7046-59 {{SGDpaper|S000044194}} PMID 9003780</ref><ref name='S000066166'>Song J, et al. (2001) Molecular interactions of the Gbeta binding domain of the Ste20p/PAK family of protein kinases. An isolated but fully functional Gbeta binding domain from Ste20p is only partially folded as shown by heteronuclear NMR spectroscopy. J Biol Chem 276(44):41205-12 {{SGDpaper|S000066166}} PMID 11509560</ref><ref name='S000129348'>Bartholomew CR and Hardy CF (2009) The p21-Activated Kinases Cla4 and Ste20 Regulate Vacuole Inheritance in S. cerevisiae. Eukaryot Cell
  {{SGDpaper|S000066166}} PMID 11509560</ref>
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  {{SGDpaper|S000129348}} PMID 19218422</ref>
 
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Revision as of 13:05, 2 April 2009

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Systematic name YHL007C
Gene name STE20
Aliases
Feature type ORF, Verified
Coordinates Chr VIII:97933..95114
Primary SGDID S000000999


Description of YHL007C: Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, involved in pheromone response, pseudohyphal/invasive growth, and vacuole inheritance; GBB motif (found in noncatalytic domains of PAKs) binds Ste4p[1][2][3]




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References

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  1. Peter M, et al. (1996) Functional analysis of the interaction between the small GTP binding protein Cdc42 and the Ste20 protein kinase in yeast. EMBO J 15(24):7046-59 SGD PMID 9003780
  2. Song J, et al. (2001) Molecular interactions of the Gbeta binding domain of the Ste20p/PAK family of protein kinases. An isolated but fully functional Gbeta binding domain from Ste20p is only partially folded as shown by heteronuclear NMR spectroscopy. J Biol Chem 276(44):41205-12 SGD PMID 11509560
  3. Bartholomew CR and Hardy CF (2009) The p21-Activated Kinases Cla4 and Ste20 Regulate Vacuole Inheritance in S. cerevisiae. Eukaryot Cell SGD PMID 19218422

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