Difference between revisions of "YGR280C"
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| − | '''Description of YGR280C:''' Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain<ref name='S000076163'>Lin J and Blackburn EH (2004) Nucleolar protein PinX1p regulates telomerase by sequestering its protein catalytic subunit in an inactive complex lacking telomerase RNA. Genes Dev 18(4):387-96 {{SGDpaper|S000076163}} PMID 14977919</ref><ref name='S000071554'>Guglielmi B and Werner M (2002) The yeast homolog of human PinX1 is involved in rRNA and small nucleolar RNA maturation, not in telomere elongation inhibition. J Biol Chem 277(38):35712-9 {{SGDpaper|S000071554}} PMID 12107183 | + | '''Description of YGR280C:''' Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain<ref name='S000076163'>Lin J and Blackburn EH (2004) Nucleolar protein PinX1p regulates telomerase by sequestering its protein catalytic subunit in an inactive complex lacking telomerase RNA. Genes Dev 18(4):387-96 {{SGDpaper|S000076163}} PMID 14977919</ref><ref name='S000069787'>Zhou XZ and Lu KP (2001) The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor. Cell 107(3):347-59 {{SGDpaper|S000069787}} PMID 11701125</ref><ref name='S000071554'>Guglielmi B and Werner M (2002) The yeast homolog of human PinX1 is involved in rRNA and small nucleolar RNA maturation, not in telomere elongation inhibition. J Biol Chem 277(38):35712-9 |
| − | + | {{SGDpaper|S000071554}} PMID 12107183</ref> | |
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Revision as of 13:05, 31 March 2009
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| Systematic name | YGR280C |
| Gene name | PXR1 |
| Aliases | GNO1 |
| Feature type | ORF, Verified |
| Coordinates | Chr VII:1051732..1050917 |
| Primary SGDID | S000003512 |
Description of YGR280C: Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain[1][2][3]
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References
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- ↑ Lin J and Blackburn EH (2004) Nucleolar protein PinX1p regulates telomerase by sequestering its protein catalytic subunit in an inactive complex lacking telomerase RNA. Genes Dev 18(4):387-96 SGD PMID 14977919
- ↑ Zhou XZ and Lu KP (2001) The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor. Cell 107(3):347-59 SGD PMID 11701125
- ↑ Guglielmi B and Werner M (2002) The yeast homolog of human PinX1 is involved in rRNA and small nucleolar RNA maturation, not in telomere elongation inhibition. J Biol Chem 277(38):35712-9 SGD PMID 12107183
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