Difference between revisions of "YBR060C"
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| − | '''Description of YBR060C:''' Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; interacts with Spp1p and with trimethylated histone H3; phosphorylated by Cdc28p<ref name=' | + | '''Description of YBR060C:''' Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; interacts with Spp1p and with trimethylated histone H3; phosphorylated by Cdc28p<ref name='S000069533'>Bell SP (2002) The origin recognition complex: from simple origins to complex functions. Genes Dev 16(6):659-72 {{SGDpaper|S000069533}} PMID 11914271</ref><ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 {{SGDpaper|S000074306}} PMID 14574415</ref><ref name='S000127968'>Kan J, et al. (2008) Origin Recognition Complex (ORC) Mediates Histone 3 Lysine 4 Methylation through Cooperation with Spp1 in Saccharomyces cerevisiae. J Biol Chem 283(49):33803-7 |
| − | {{SGDpaper| | + | {{SGDpaper|S000127968}} PMID 18845545</ref> |
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Revision as of 13:05, 31 March 2009
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| Systematic name | YBR060C |
| Gene name | ORC2 |
| Aliases | RRR1, SIR5 |
| Feature type | ORF, Verified |
| Coordinates | Chr II:362512..360650 |
| Primary SGDID | S000000264 |
Description of YBR060C: Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; interacts with Spp1p and with trimethylated histone H3; phosphorylated by Cdc28p[1][2][3]
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Protein Details
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [2] [4]
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References
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- ↑ Bell SP (2002) The origin recognition complex: from simple origins to complex functions. Genes Dev 16(6):659-72 SGD PMID 11914271
- ↑ 2.0 2.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
- ↑ Kan J, et al. (2008) Origin Recognition Complex (ORC) Mediates Histone 3 Lysine 4 Methylation through Cooperation with Spp1 in Saccharomyces cerevisiae. J Biol Chem 283(49):33803-7 SGD PMID 18845545
- ↑ submitted by Jeff Ubersax on 2004-01-21
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