Difference between revisions of "YLR378C"
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| − | '''Description of YLR378C:''' Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER<ref name='S000075941'>Plath K, et al. (2004) Interactions between Sec complex and prepro-alpha-factor during posttranslational protein transport into the endoplasmic reticulum. Mol Biol Cell 15(1):1-10 {{SGDpaper|S000075941}} PMID 14617809</ref><ref name='S000060140'>Young BP, et al. (2001) Sec63p and Kar2p are required for the translocation of SRP-dependent precursors into the yeast endoplasmic reticulum in vivo. EMBO J 20(1-2):262-71 {{SGDpaper|S000060140}} PMID 11226176</ref><ref name='S000044438'>Romisch K (1999) Surfing the Sec61 channel: bidirectional protein translocation across the ER membrane. J Cell Sci 112 ( Pt 23 | + | '''Description of YLR378C:''' Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER<ref name='S000075941'>Plath K, et al. (2004) Interactions between Sec complex and prepro-alpha-factor during posttranslational protein transport into the endoplasmic reticulum. Mol Biol Cell 15(1):1-10 {{SGDpaper|S000075941}} PMID 14617809</ref><ref name='S000060140'>Young BP, et al. (2001) Sec63p and Kar2p are required for the translocation of SRP-dependent precursors into the yeast endoplasmic reticulum in vivo. EMBO J 20(1-2):262-71 {{SGDpaper|S000060140}} PMID 11226176</ref><ref name='S000044438'>Romisch K (1999) Surfing the Sec61 channel: bidirectional protein translocation across the ER membrane. J Cell Sci 112 ( Pt 23):4185-91 |
{{SGDpaper|S000044438}} PMID 10564637</ref> | {{SGDpaper|S000044438}} PMID 10564637</ref> | ||
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Revision as of 06:21, 26 February 2009
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| Systematic name | YLR378C |
| Gene name | SEC61 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XII:877177..875735 |
| Primary SGDID | S000004370 |
Description of YLR378C: Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER[1][2][3]
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References
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- ↑ Plath K, et al. (2004) Interactions between Sec complex and prepro-alpha-factor during posttranslational protein transport into the endoplasmic reticulum. Mol Biol Cell 15(1):1-10 SGD PMID 14617809
- ↑ Young BP, et al. (2001) Sec63p and Kar2p are required for the translocation of SRP-dependent precursors into the yeast endoplasmic reticulum in vivo. EMBO J 20(1-2):262-71 SGD PMID 11226176
- ↑ Romisch K (1999) Surfing the Sec61 channel: bidirectional protein translocation across the ER membrane. J Cell Sci 112 ( Pt 23):4185-91 SGD PMID 10564637
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