Difference between revisions of "YGR158C"

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'''Description of YGR158C:''' 3'5' exoribonuclease, exosome subunit; nucleolar protein involved in export of mRNA and ribosomal subunits; homologous to the E. coli exonuclease RNase PH<ref name='S000042735'>Allmang C, et al. (2000) Degradation of ribosomal RNA precursors by the exosome. Nucleic Acids Res 28(8):1684-91 {{SGDpaper|S000042735}} PMID 10734186</ref><ref name='S000041453'>Kadowaki T, et al. (1995) Mutations in nucleolar proteins lead to nucleolar accumulation of polyA+ RNA in Saccharomyces cerevisiae. Mol Biol Cell 6(9):1103-10
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'''Description of YGR158C:''' Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6)<ref name='S000120282'>Dziembowski A, et al. (2007) A single subunit, Dis3, is essentially responsible for yeast exosome core activity. Nat Struct Mol Biol 14(1):15-22 {{SGDpaper|S000120282}} PMID 17173052</ref><ref name='S000120270'>Liu Q, et al. (2006) Reconstitution, activities, and structure of the eukaryotic RNA exosome. Cell 127(6):1223-37 {{SGDpaper|S000120270}} PMID 17174896</ref><ref name='S000117042'>Synowsky SA, et al. (2006) Probing genuine strong interactions and post-translational modifications in the heterogeneous yeast exosome protein complex. Mol Cell Proteomics 5(9):1581-92 {{SGDpaper|S000117042}} PMID 16829593</ref><ref name='S000041327'>Allmang C, et al. (1999) The yeast exosome and human PM-Scl are related complexes of 3' --&gt; 5' exonucleases. Genes Dev 13(16):2148-58
  {{SGDpaper|S000041453}} PMID 8534909</ref>
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  {{SGDpaper|S000041327}} PMID 10465791</ref>
 
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Revision as of 06:21, 26 February 2009

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Systematic name YGR158C
Gene name MTR3
Aliases
Feature type ORF, Verified
Coordinates Chr VII:806026..805274
Primary SGDID S000003390


Description of YGR158C: Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6)[1][2][3][4]




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References

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  1. Dziembowski A, et al. (2007) A single subunit, Dis3, is essentially responsible for yeast exosome core activity. Nat Struct Mol Biol 14(1):15-22 SGD PMID 17173052
  2. Liu Q, et al. (2006) Reconstitution, activities, and structure of the eukaryotic RNA exosome. Cell 127(6):1223-37 SGD PMID 17174896
  3. Synowsky SA, et al. (2006) Probing genuine strong interactions and post-translational modifications in the heterogeneous yeast exosome protein complex. Mol Cell Proteomics 5(9):1581-92 SGD PMID 16829593
  4. Allmang C, et al. (1999) The yeast exosome and human PM-Scl are related complexes of 3' --> 5' exonucleases. Genes Dev 13(16):2148-58 SGD PMID 10465791

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