Difference between revisions of "YDR397C"

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'''Description of YDR397C:''' Subunit of a heterodimeric NC2 transcription regulator complex with Bur6p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2beta<ref name='S000078394'>Cang Y and Prelich G (2002) Direct stimulation of transcription by negative cofactor 2 (NC2) through TATA-binding protein (TBP). Proc Natl Acad Sci U S A 99(20):12727-32 {{SGDpaper|S000078394}} PMID 12237409</ref><ref name='S000058072'>Gadbois EL, et al. (1997) Functional antagonism between RNA polymerase II holoenzyme and global negative regulator NC2 in vivo. Proc Natl Acad Sci U S A 94(7):3145-50 {{SGDpaper|S000058072}} PMID 9096360</ref><ref name='S000045829'>Lemaire M, et al. (2000) The NC2 repressor is dispensable in yeast mutated for the Sin4p component of the holoenzyme and plays roles similar to Mot1p in vivo. Mol Microbiol 36(1):163-73
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'''Description of YDR397C:''' Subunit of a heterodimeric NC2 transcription regulator complex with Bur6p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2beta<ref name='S000045829'>Lemaire M, et al. (2000) The NC2 repressor is dispensable in yeast mutated for the Sin4p component of the holoenzyme and plays roles similar to Mot1p in vivo. Mol Microbiol 36(1):163-73 {{SGDpaper|S000045829}} PMID 10760173</ref><ref name='S000058072'>Gadbois EL, et al. (1997) Functional antagonism between RNA polymerase II holoenzyme and global negative regulator NC2 in vivo. Proc Natl Acad Sci U S A 94(7):3145-50 {{SGDpaper|S000058072}} PMID 9096360</ref><ref name='S000078394'>Cang Y and Prelich G (2002) Direct stimulation of transcription by negative cofactor 2 (NC2) through TATA-binding protein (TBP). Proc Natl Acad Sci U S A 99(20):12727-32
  {{SGDpaper|S000045829}} PMID 10760173</ref>
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  {{SGDpaper|S000078394}} PMID 12237409</ref>
 
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Revision as of 03:15, 19 December 2008

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Systematic name YDR397C
Gene name NCB2
Aliases YDR1
Feature type ORF, Verified
Coordinates Chr IV:1266891..1266359
Primary SGDID S000002805


Description of YDR397C: Subunit of a heterodimeric NC2 transcription regulator complex with Bur6p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2beta[1][2][3]




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References

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  1. Lemaire M, et al. (2000) The NC2 repressor is dispensable in yeast mutated for the Sin4p component of the holoenzyme and plays roles similar to Mot1p in vivo. Mol Microbiol 36(1):163-73 SGD PMID 10760173
  2. Gadbois EL, et al. (1997) Functional antagonism between RNA polymerase II holoenzyme and global negative regulator NC2 in vivo. Proc Natl Acad Sci U S A 94(7):3145-50 SGD PMID 9096360
  3. Cang Y and Prelich G (2002) Direct stimulation of transcription by negative cofactor 2 (NC2) through TATA-binding protein (TBP). Proc Natl Acad Sci U S A 99(20):12727-32 SGD PMID 12237409

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