Difference between revisions of "YOR211C"
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| + | === Protein Details === | ||
| + | [[Category:Topic:Protein Details]] | ||
| + | ==== Mature Length (direct evidence) ==== | ||
| + | [[Category:Topic:Protein Details:Mature Length (direct evidence)]] | ||
| + | '''Protein length''': 822 aa | ||
| + | The N-terminus of the mature large isoform of Mgm1p starts at position 81 (ISHFPKII...; 822 aa). The N-terminus of the mature short isoform of Mgm1p starts at position 161 (ATLIAATS...; 742 aa) are alternatively at position 163 (LIAATS...; 740 aa). <ref name='S000073854'>Herlan M, et al. (2003) Processing of Mgm1 by the rhomboid-type protease Pcp1 is required for maintenance of mitochondrial morphology and of mitochondrial DNA. J Biol Chem 278(30):27781-8 {{SGDpaper|S000073854}} PMID 12707284</ref> <ref name = 'CAset9617-2003-09-25'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9617 Andreas Reichert] on 2003-09-25</ref> | ||
| + | {{ShortCenteredHR}} | ||
| + | ==== Protein Function/Process ==== | ||
| + | [[Category:Topic:Protein Details:Protein Function/Process]] | ||
| + | |||
| + | Both isoforms of Mgm1p are required for maintenance of mitochondrial morphology and of mitochondrial DNA. <ref name='S000073854'>Herlan M, et al. (2003) Processing of Mgm1 by the rhomboid-type protease Pcp1 is required for maintenance of mitochondrial morphology and of mitochondrial DNA. J Biol Chem 278(30):27781-8 {{SGDpaper|S000073854}} PMID 12707284</ref> <ref name = 'CAset9617-2003-09-25'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9617 Andreas Reichert] on 2003-09-25</ref> | ||
| + | |||
| + | {{ShortCenteredHR}} | ||
| + | ==== Protein Localization ==== | ||
| + | [[Category:Topic:Protein Details:Protein Localization]] | ||
| + | |||
| + | Large and short isoform are localized to the mitochondrial intermembrane space. The large isoform is anchored via a single N-terminal transmembrane segment to the mitochondrial inner membrane which is absent in the short isoform. <ref name='S000073854'>Herlan M, et al. (2003) Processing of Mgm1 by the rhomboid-type protease Pcp1 is required for maintenance of mitochondrial morphology and of mitochondrial DNA. J Biol Chem 278(30):27781-8 {{SGDpaper|S000073854}} PMID 12707284</ref> <ref name = 'CAset9617-2003-09-25'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9617 Andreas Reichert] on 2003-09-25</ref> | ||
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| + | {{ShortCenteredHR}} | ||
__TOC__ | __TOC__ | ||
==Community Commentary== | ==Community Commentary== | ||
{{CommentaryHelp}} | {{CommentaryHelp}} | ||
| + | === Protein Details === | ||
| + | [[Category:Topic:Protein Details]] | ||
| + | ==== Mature Length (direct evidence) ==== | ||
| + | [[Category:Topic:Protein Details:Mature Length (direct evidence)]] | ||
| + | '''Protein length''': 822 aa | ||
| + | The N-terminus of the mature large isoform of Mgm1p starts at position 81 (ISHFPKII...; 822 aa). The N-terminus of the mature short isoform of Mgm1p starts at position 161 (ATLIAATS...; 742 aa) are alternatively at position 163 (LIAATS...; 740 aa). <ref name='S000073854'>Herlan M, et al. (2003) Processing of Mgm1 by the rhomboid-type protease Pcp1 is required for maintenance of mitochondrial morphology and of mitochondrial DNA. J Biol Chem 278(30):27781-8 {{SGDpaper|S000073854}} PMID 12707284</ref> <ref name = 'CAset9617-2003-09-25'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9617 Andreas Reichert] on 2003-09-25</ref> | ||
| + | |||
| + | {{ShortCenteredHR}} | ||
| + | ==== Protein Function/Process ==== | ||
| + | [[Category:Topic:Protein Details:Protein Function/Process]] | ||
| + | |||
| + | Both isoforms of Mgm1p are required for maintenance of mitochondrial morphology and of mitochondrial DNA. <ref name='S000073854'>Herlan M, et al. (2003) Processing of Mgm1 by the rhomboid-type protease Pcp1 is required for maintenance of mitochondrial morphology and of mitochondrial DNA. J Biol Chem 278(30):27781-8 {{SGDpaper|S000073854}} PMID 12707284</ref> <ref name = 'CAset9617-2003-09-25'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9617 Andreas Reichert] on 2003-09-25</ref> | ||
| + | |||
| + | {{ShortCenteredHR}} | ||
| + | ==== Protein Localization ==== | ||
| + | [[Category:Topic:Protein Details:Protein Localization]] | ||
| + | |||
| + | Large and short isoform are localized to the mitochondrial intermembrane space. The large isoform is anchored via a single N-terminal transmembrane segment to the mitochondrial inner membrane which is absent in the short isoform. <ref name='S000073854'>Herlan M, et al. (2003) Processing of Mgm1 by the rhomboid-type protease Pcp1 is required for maintenance of mitochondrial morphology and of mitochondrial DNA. J Biol Chem 278(30):27781-8 {{SGDpaper|S000073854}} PMID 12707284</ref> <ref name = 'CAset9617-2003-09-25'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9617 Andreas Reichert] on 2003-09-25</ref> | ||
| + | {{ShortCenteredHR}} | ||
==References== | ==References== | ||
<!-- REFERENCES ARE AUTOMATICALLY GENERATED. PLEASE DON'T EDIT THIS SECTION--> | <!-- REFERENCES ARE AUTOMATICALLY GENERATED. PLEASE DON'T EDIT THIS SECTION--> | ||
{{RefHelp}} | {{RefHelp}} | ||
Revision as of 16:05, 23 January 2007
Share your knowledge...Edit this entry!
| Systematic name | YOR211C | |
| Gene name | MGM1 | |
| Aliases | MNA1 | |
| Feature type | ORF, Verified | |
| Coordinates | Chr XV:741570..738925 | |
| Don't edit this box! It's automatically regenerated, and edits will be lost when the update script runs. | ||
Description of YOR211C: Mitochondrial GTPase related to dynamin, present in a complex containing Ugo1p and Fzo1p; required for normal morphology of cristae and for stability of Tim11p; homolog of human OPA1 involved in autosomal dominant optic atrophy[1][2][3][4]
Protein Details
Mature Length (direct evidence)
Protein length: 822 aa The N-terminus of the mature large isoform of Mgm1p starts at position 81 (ISHFPKII...; 822 aa). The N-terminus of the mature short isoform of Mgm1p starts at position 161 (ATLIAATS...; 742 aa) are alternatively at position 163 (LIAATS...; 740 aa). [5] [6]
Protein Function/Process
Both isoforms of Mgm1p are required for maintenance of mitochondrial morphology and of mitochondrial DNA. [5] [6]
Protein Localization
Large and short isoform are localized to the mitochondrial intermembrane space. The large isoform is anchored via a single N-terminal transmembrane segment to the mitochondrial inner membrane which is absent in the short isoform. [5] [6]
Contents
Community Commentary
About Community Commentary. Please share your knowledge!
Protein Details
Mature Length (direct evidence)
Protein length: 822 aa The N-terminus of the mature large isoform of Mgm1p starts at position 81 (ISHFPKII...; 822 aa). The N-terminus of the mature short isoform of Mgm1p starts at position 161 (ATLIAATS...; 742 aa) are alternatively at position 163 (LIAATS...; 740 aa). [5] [6]
Protein Function/Process
Both isoforms of Mgm1p are required for maintenance of mitochondrial morphology and of mitochondrial DNA. [5] [6]
Protein Localization
Large and short isoform are localized to the mitochondrial intermembrane space. The large isoform is anchored via a single N-terminal transmembrane segment to the mitochondrial inner membrane which is absent in the short isoform. [5] [6]
References
See Help:References on how to add references
- ↑ Sesaki H and Jensen RE (2004) Ugo1p links the Fzo1p and Mgm1p GTPases for mitochondrial fusion. J Biol Chem 279(27):28298-303 SGD PMID 15087460
- ↑ Sesaki H, et al. (2003) Mgm1p, a dynamin-related GTPase, is essential for fusion of the mitochondrial outer membrane. Mol Biol Cell 14(6):2342-56 SGD PMID 12808034
- ↑ Olichon A, et al. (2002) The human dynamin-related protein OPA1 is anchored to the mitochondrial inner membrane facing the inter-membrane space. FEBS Lett 523(1-3):171-6 SGD PMID 12123827
- ↑ Amutha B, et al. (2004) A novel role of Mgm1p, a dynamin-related GTPase, in ATP synthase assembly and cristae formation/maintenance. Biochem J 381(Pt 1):19-23 SGD PMID 15125685
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 Herlan M, et al. (2003) Processing of Mgm1 by the rhomboid-type protease Pcp1 is required for maintenance of mitochondrial morphology and of mitochondrial DNA. J Biol Chem 278(30):27781-8 SGD PMID 12707284
- ↑ 6.0 6.1 6.2 6.3 6.4 6.5 submitted by Andreas Reichert on 2003-09-25
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