Difference between revisions of "YER019W"
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| − | '''Description of YER019W:''' Mitochondrial membrane localized inositol phosphosphingolipid phospholipase C, hydrolyzes complex sphingolipids to produce ceramide; activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol; mediates Na+ and Li+ halotolerance<ref name=' | + | '''Description of YER019W:''' Mitochondrial membrane localized inositol phosphosphingolipid phospholipase C, hydrolyzes complex sphingolipids to produce ceramide; activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol; mediates Na+ and Li+ halotolerance<ref name='S000059300'>Sawai H, et al. (2000) Identification of ISC1 (YER019w) as inositol phosphosphingolipid phospholipase C in Saccharomyces cerevisiae. J Biol Chem 275(50):39793-8 {{SGDpaper|S000059300}} PMID 11006294</ref><ref name='S000070403'>Betz C, et al. (2002) ISC1-encoded inositol phosphosphingolipid phospholipase C is involved in Na+/Li+ halotolerance of Saccharomyces cerevisiae. Eur J Biochem 269(16):4033-9 {{SGDpaper|S000070403}} PMID 12180980</ref><ref name='S000072039'>Okamoto Y, et al. (2002) Structural requirements for selective binding of ISC1 to anionic phospholipids. J Biol Chem 277(48):46470-7 |
| − | {{SGDpaper| | + | {{SGDpaper|S000072039}} PMID 12244059</ref> |
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Revision as of 03:40, 18 December 2008
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| Systematic name | YER019W |
| Gene name | ISC1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr V:192796..194229 |
| Primary SGDID | S000000821 |
Description of YER019W: Mitochondrial membrane localized inositol phosphosphingolipid phospholipase C, hydrolyzes complex sphingolipids to produce ceramide; activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol; mediates Na+ and Li+ halotolerance[1][2][3]
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References
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- ↑ Sawai H, et al. (2000) Identification of ISC1 (YER019w) as inositol phosphosphingolipid phospholipase C in Saccharomyces cerevisiae. J Biol Chem 275(50):39793-8 SGD PMID 11006294
- ↑ Betz C, et al. (2002) ISC1-encoded inositol phosphosphingolipid phospholipase C is involved in Na+/Li+ halotolerance of Saccharomyces cerevisiae. Eur J Biochem 269(16):4033-9 SGD PMID 12180980
- ↑ Okamoto Y, et al. (2002) Structural requirements for selective binding of ISC1 to anionic phospholipids. J Biol Chem 277(48):46470-7 SGD PMID 12244059
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