Difference between revisions of "YOL090W"

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|nowrap| Chr XV:147382..150276
 
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==Community Commentary==
 
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==References==
 
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Revision as of 07:18, 30 January 2007

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Systematic name YOL090W
Gene name MSH2
Aliases PMS5
Feature type ORF, Verified
Coordinates Chr XV:147382..150276


Description of YOL090W: Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity; Msh2p-Msh6p binds to and hydrolyzes ATP[1][2]




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Community Commentary

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References

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  1. Kijas AW, et al. (2003) Msh2 separation of function mutations confer defects in the initiation steps of mismatch repair. J Mol Biol 331(1):123-38 SGD PMID 12875840
  2. Antony E and Hingorani MM (2003) Mismatch recognition-coupled stabilization of Msh2-Msh6 in an ATP-bound state at the initiation of DNA repair. Biochemistry 42(25):7682-93 SGD PMID 12820877

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