Difference between revisions of "YOL068C"
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| + | === Interactions === | ||
| + | [[Category:Topic:Interactions]] | ||
| + | ==== Physical ==== | ||
| + | [[Category:Topic:Interactions:Physical]] | ||
| + | Physical interaction with Sum1 [[Category:Physical Interactions with Sum1]]<br> | ||
| + | Sum1, a repressor of middle meiotic genes, was found to interact with Hst1 by coimmunoprecipitation. A neomorphic allele of Sum1 (Sum1-1) also interacts with Hst1. Hst1 is a histone deacetylase, and it is required for repression of some Sum1 targets. <ref name='S000060164'>Rusche LN and Rine J (2001) Conversion of a gene-specific repressor to a regional silencer. Genes Dev 15(8):955-67 {{SGDpaper|S000060164}} PMID 11316790</ref> <ref name = 'CAset9199-2003-03-14'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9199 Hunter Fraser] on 2003-03-14</ref> | ||
| + | {{ShortCenteredHR}} | ||
__TOC__ | __TOC__ | ||
==Community Commentary== | ==Community Commentary== | ||
{{CommentaryHelp}} | {{CommentaryHelp}} | ||
| + | === Interactions === | ||
| + | [[Category:Topic:Interactions]] | ||
| + | ==== Physical ==== | ||
| + | [[Category:Topic:Interactions:Physical]] | ||
| + | Physical interaction with Sum1 [[Category:Physical Interactions with Sum1]]<br> | ||
| + | Sum1, a repressor of middle meiotic genes, was found to interact with Hst1 by coimmunoprecipitation. A neomorphic allele of Sum1 (Sum1-1) also interacts with Hst1. Hst1 is a histone deacetylase, and it is required for repression of some Sum1 targets. <ref name='S000060164'>Rusche LN and Rine J (2001) Conversion of a gene-specific repressor to a regional silencer. Genes Dev 15(8):955-67 {{SGDpaper|S000060164}} PMID 11316790</ref> <ref name = 'CAset9199-2003-03-14'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9199 Hunter Fraser] on 2003-03-14</ref> | ||
| + | {{ShortCenteredHR}} | ||
==References== | ==References== | ||
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Revision as of 16:05, 23 January 2007
Share your knowledge...Edit this entry!
| Systematic name | YOL068C | |
| Gene name | HST1 | |
| Aliases | ||
| Feature type | ORF, Verified | |
| Coordinates | Chr XV:201879..200368 | |
| Don't edit this box! It's automatically regenerated, and edits will be lost when the update script runs. | ||
Description of YOL068C: NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and mitotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance[1][2][3][4][5][6]
Interactions
Physical
Physical interaction with Sum1
Sum1, a repressor of middle meiotic genes, was found to interact with Hst1 by coimmunoprecipitation. A neomorphic allele of Sum1 (Sum1-1) also interacts with Hst1. Hst1 is a histone deacetylase, and it is required for repression of some Sum1 targets. [4] [7]
Contents
Community Commentary
About Community Commentary. Please share your knowledge!
Interactions
Physical
Physical interaction with Sum1
Sum1, a repressor of middle meiotic genes, was found to interact with Hst1 by coimmunoprecipitation. A neomorphic allele of Sum1 (Sum1-1) also interacts with Hst1. Hst1 is a histone deacetylase, and it is required for repression of some Sum1 targets. [4] [7]
References
See Help:References on how to add references
- ↑ Askree SH, et al. (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63 SGD PMID 15161972
- ↑ Pijnappel WW, et al. (2001) The S. cerevisiae SET3 complex includes two histone deacetylases, Hos2 and Hst1, and is a meiotic-specific repressor of the sporulation gene program. Genes Dev 15(22):2991-3004 SGD PMID 11711434
- ↑ Sutton A, et al. (2001) A novel form of transcriptional silencing by Sum1-1 requires Hst1 and the origin recognition complex. Mol Cell Biol 21(10):3514-22 SGD PMID 11313477
- ↑ 4.0 4.1 4.2 Rusche LN and Rine J (2001) Conversion of a gene-specific repressor to a regional silencer. Genes Dev 15(8):955-67 SGD PMID 11316790
- ↑ Smith JS, et al. (2000) A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family. Proc Natl Acad Sci U S A 97(12):6658-63 SGD PMID 10841563
- ↑ Xie J, et al. (1999) Sum1 and Hst1 repress middle sporulation-specific gene expression during mitosis in Saccharomyces cerevisiae. EMBO J 18(22):6448-54 SGD PMID 10562556
- ↑ 7.0 7.1 submitted by Hunter Fraser on 2003-03-14
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