Difference between revisions of "YOL006C"

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==Community Commentary==
 
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==References==
 
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Revision as of 07:18, 30 January 2007

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Systematic name YOL006C
Gene name TOP1
Aliases MAK1, MAK17
Feature type ORF, Verified
Coordinates Chr XV:315388..313079


Description of YOL006C: Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination[1][2][3]




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Community Commentary

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References

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  1. Woo MH, et al. (2003) Locking the DNA topoisomerase I protein clamp inhibits DNA rotation and induces cell lethality. Proc Natl Acad Sci U S A 100(24):13767-72 SGD PMID 14585933
  2. Roca J (1995) The mechanisms of DNA topoisomerases. Trends Biochem Sci 20(4):156-60 SGD PMID 7770916
  3. Thrash C, et al. (1985) Cloning, characterization, and sequence of the yeast DNA topoisomerase I gene. Proc Natl Acad Sci U S A 82(13):4374-8 SGD PMID 2989818

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