Difference between revisions of "YOL034W"
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| − | Smc5 is one of the two SMC proteins that forms the core of the Smc5-Smc6 complex. The Smc5-Smc6 complex is, together with cohesin and condensin, one of the three essential eukaryotic SMC complexes. The complex has six non-Smc subunits, named Nse1, Nse2, Nse3, Nse4, Nse5 and Nse6. The Smc5-Smc6 complex has been shown to have a role in DNA repair, as well as an essential function. Smc5-Smc6 participates in an undefined step of homologous recombination <ref>Onoda F, et al. (2004) SMC6 is required for MMS-induced interchromosomal and sister chromatid recombinations in Saccharomyces cerevisiae. DNA Repair (Amst). 3(4):429-39</ref> and it is recruited to DNA double strand breaks to promote sister chromatid recombination <ref>de Piccoli G, et al. (2006) Smc5-Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination. Nat Cell Biol. 8(9):1032-4 </ref>. The essential function of the Smc5-Smc6 complex | + | Smc5 is one of the two SMC proteins that forms the core of the Smc5-Smc6 complex. The Smc5-Smc6 complex is, together with cohesin and condensin, one of the three essential eukaryotic SMC complexes. The complex has six non-Smc subunits, named Nse1, Nse2, Nse3, Nse4, Nse5 and Nse6. The Smc5-Smc6 complex has been shown to have a role in DNA repair, as well as an essential function. Smc5-Smc6 participates in an undefined step of homologous recombination <ref>Onoda F, et al. (2004) SMC6 is required for MMS-induced interchromosomal and sister chromatid recombinations in Saccharomyces cerevisiae. DNA Repair (Amst). 3(4):429-39</ref> and it is recruited to DNA double strand breaks to promote sister chromatid recombination <ref>de Piccoli G, et al. (2006) Smc5-Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination. Nat Cell Biol. 8(9):1032-4 </ref>. The essential function of the Smc5-Smc6 complex is most probably related to chromosome segregation. The ribosomal DNA array (rDNA) appears to be the most affected locus, and <i>smc5-smc6</i> thermosensitive mutants fail to segregate the rDNA when grown at the restrictive temperature <ref>Torres-Rosell J, et al. (2005) SMC5 and SMC6 genes are required for the segregation of repetitive chromosome regions. Nat Cell Biol. 2005 7(4):412-9 </ref> <ref>Cost GJ, Cozzarelli NR (2006) Smc5p promotes faithful chromosome transmission and DNA repair in Saccharomyces cerevisiae. Genetics 172(4):2185-200.</ref> |
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Revision as of 04:22, 30 July 2007
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| Systematic name | YOL034W |
| Gene name | SMC5 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XV:259924..263205 |
| Primary SGDID | S000005394 |
Description of YOL034W: Structural maintenance of chromosomes (SMC) protein; essential subunit of the Mms21-Smc5-Smc6 complex; required for growth and DNA repair; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair[1][2][3]
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Community Commentary
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Smc5 is one of the two SMC proteins that forms the core of the Smc5-Smc6 complex. The Smc5-Smc6 complex is, together with cohesin and condensin, one of the three essential eukaryotic SMC complexes. The complex has six non-Smc subunits, named Nse1, Nse2, Nse3, Nse4, Nse5 and Nse6. The Smc5-Smc6 complex has been shown to have a role in DNA repair, as well as an essential function. Smc5-Smc6 participates in an undefined step of homologous recombination [4] and it is recruited to DNA double strand breaks to promote sister chromatid recombination [5]. The essential function of the Smc5-Smc6 complex is most probably related to chromosome segregation. The ribosomal DNA array (rDNA) appears to be the most affected locus, and smc5-smc6 thermosensitive mutants fail to segregate the rDNA when grown at the restrictive temperature [6] [7]
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References
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- ↑ Zhao X and Blobel G (2005) A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization. Proc Natl Acad Sci U S A 102(13):4777-82 SGD PMID 15738391
- ↑ Onoda F, et al. (2004) SMC6 is required for MMS-induced interchromosomal and sister chromatid recombinations in Saccharomyces cerevisiae. DNA Repair (Amst) 3(4):429-39 SGD PMID 15010319
- ↑ Fujioka Y, et al. (2002) Identification of a novel non-structural maintenance of chromosomes (SMC) component of the SMC5-SMC6 complex involved in DNA repair. J Biol Chem 277(24):21585-91 SGD PMID 11927594
- ↑ Onoda F, et al. (2004) SMC6 is required for MMS-induced interchromosomal and sister chromatid recombinations in Saccharomyces cerevisiae. DNA Repair (Amst). 3(4):429-39
- ↑ de Piccoli G, et al. (2006) Smc5-Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination. Nat Cell Biol. 8(9):1032-4
- ↑ Torres-Rosell J, et al. (2005) SMC5 and SMC6 genes are required for the segregation of repetitive chromosome regions. Nat Cell Biol. 2005 7(4):412-9
- ↑ Cost GJ, Cozzarelli NR (2006) Smc5p promotes faithful chromosome transmission and DNA repair in Saccharomyces cerevisiae. Genetics 172(4):2185-200.
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