Difference between revisions of "YJR070C"

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==Community Commentary==
 
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==References==
 
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Revision as of 08:18, 30 January 2007

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Systematic name YJR070C
Gene name LIA1
Aliases MMD1
Feature type ORF, Verified
Coordinates Chr X:570591..569614


Description of YJR070C: Deoxyhypusine hydroxylase, a HEAT-repeat containing metalloenzyme that catalyses hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning[1][2][3]




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Community Commentary

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References

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  1. Park JH, et al. (2006) Molecular cloning, expression, and structural prediction of deoxyhypusine hydroxylase: a HEAT-repeat-containing metalloenzyme. Proc Natl Acad Sci U S A 103(1):51-6 SGD PMID 16371467
  2. Weir BA and Yaffe MP (2004) Mmd1p, a novel, conserved protein essential for normal mitochondrial morphology and distribution in the fission yeast Schizosaccharomyces pombe. Mol Biol Cell 15(4):1656-65 SGD PMID 14767070
  3. Thompson GM, et al. (2003) Mapping eIF5A binding sites for Dys1 and Lia1: in vivo evidence for regulation of eIF5A hypusination. FEBS Lett 555(3):464-8 SGD PMID 14675757

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