Difference between revisions of "YPR140W"
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| − | '''Description of YPR140W:''' Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; | + | '''Description of YPR140W:''' Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; human ortholog tafazzin is implicated in Barth syndrome<ref name='S000080116'>Testet E, et al. (2005) Ypr140wp, 'the yeast tafazzin', displays a mitochondrial lysophosphatidylcholine (lyso-PC) acyltransferase activity related to triacylglycerol and mitochondrial lipid synthesis. Biochem J 387(Pt 3):617-26 {{SGDpaper|S000080116}} PMID 15588229</ref><ref name='S000075500'>Gu Z, et al. (2004) Aberrant cardiolipin metabolism in the yeast taz1 mutant: a model for Barth syndrome. Mol Microbiol 51(1):149-58 {{SGDpaper|S000075500}} PMID 14651618</ref><ref name='S000065692'>Neuwald AF (1997) Barth syndrome may be due to an acyltransferase deficiency. Curr Biol 7(8):R465-6 |
{{SGDpaper|S000065692}} PMID 9259571</ref> | {{SGDpaper|S000065692}} PMID 9259571</ref> | ||
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Revision as of 06:21, 26 February 2009
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| Systematic name | YPR140W |
| Gene name | TAZ1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XVI:814387..815532 |
| Primary SGDID | S000006344 |
Description of YPR140W: Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; human ortholog tafazzin is implicated in Barth syndrome[1][2][3]
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References
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- ↑ Testet E, et al. (2005) Ypr140wp, 'the yeast tafazzin', displays a mitochondrial lysophosphatidylcholine (lyso-PC) acyltransferase activity related to triacylglycerol and mitochondrial lipid synthesis. Biochem J 387(Pt 3):617-26 SGD PMID 15588229
- ↑ Gu Z, et al. (2004) Aberrant cardiolipin metabolism in the yeast taz1 mutant: a model for Barth syndrome. Mol Microbiol 51(1):149-58 SGD PMID 14651618
- ↑ Neuwald AF (1997) Barth syndrome may be due to an acyltransferase deficiency. Curr Biol 7(8):R465-6 SGD PMID 9259571
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