Difference between revisions of "YOR211C"
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| − | '''Description of YOR211C:''' Mitochondrial GTPase related to dynamin, present in a complex containing Ugo1p and Fzo1p; required for normal morphology of cristae and for stability of Tim11p; homolog of human OPA1 involved in autosomal dominant optic atrophy<ref name='S000076835'>Sesaki H and Jensen RE (2004) Ugo1p links the Fzo1p and Mgm1p GTPases for mitochondrial fusion. J Biol Chem 279(27):28298-303 {{SGDpaper|S000076835}} PMID 15087460</ref><ref name='S000073565'>Sesaki H, et al. (2003) Mgm1p, a dynamin-related GTPase, is essential for fusion of the mitochondrial outer membrane. Mol Biol Cell 14(6):2342-56 {{SGDpaper|S000073565}} PMID 12808034</ref><ref name='S000070154'>Olichon A, et al. (2002) The human dynamin-related protein OPA1 is anchored to the mitochondrial inner membrane facing the inter-membrane space. FEBS Lett 523(1-3):171-6 {{SGDpaper|S000070154}} PMID 12123827 | + | '''Description of YOR211C:''' Mitochondrial GTPase related to dynamin, present in a complex containing Ugo1p and Fzo1p; required for normal morphology of cristae and for stability of Tim11p; homolog of human OPA1 involved in autosomal dominant optic atrophy<ref name='S000076835'>Sesaki H and Jensen RE (2004) Ugo1p links the Fzo1p and Mgm1p GTPases for mitochondrial fusion. J Biol Chem 279(27):28298-303 {{SGDpaper|S000076835}} PMID 15087460</ref><ref name='S000058923'>Amutha B, et al. (2004) A novel role of Mgm1p, a dynamin-related GTPase, in ATP synthase assembly and cristae formation/maintenance. Biochem J 381(Pt 1):19-23 {{SGDpaper|S000058923}} PMID 15125685</ref><ref name='S000073565'>Sesaki H, et al. (2003) Mgm1p, a dynamin-related GTPase, is essential for fusion of the mitochondrial outer membrane. Mol Biol Cell 14(6):2342-56 {{SGDpaper|S000073565}} PMID 12808034</ref><ref name='S000070154'>Olichon A, et al. (2002) The human dynamin-related protein OPA1 is anchored to the mitochondrial inner membrane facing the inter-membrane space. FEBS Lett 523(1-3):171-6 |
| − | + | {{SGDpaper|S000070154}} PMID 12123827</ref> | |
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Revision as of 06:21, 26 February 2009
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| Systematic name | YOR211C |
| Gene name | MGM1 |
| Aliases | MNA1 |
| Feature type | ORF, Verified |
| Coordinates | Chr XV:741570..738925 |
| Primary SGDID | S000005737 |
Description of YOR211C: Mitochondrial GTPase related to dynamin, present in a complex containing Ugo1p and Fzo1p; required for normal morphology of cristae and for stability of Tim11p; homolog of human OPA1 involved in autosomal dominant optic atrophy[1][2][3][4]
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Contents
Community Commentary
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Protein Details
Mature Length (direct evidence)
Protein length: 822 aa The N-terminus of the mature large isoform of Mgm1p starts at position 81 (ISHFPKII...; 822 aa). The N-terminus of the mature short isoform of Mgm1p starts at position 161 (ATLIAATS...; 742 aa) are alternatively at position 163 (LIAATS...; 740 aa). [5] [6]
Protein Function/Process
Both isoforms of Mgm1p are required for maintenance of mitochondrial morphology and of mitochondrial DNA. [5] [6]
Protein Localization
Large and short isoform are localized to the mitochondrial intermembrane space. The large isoform is anchored via a single N-terminal transmembrane segment to the mitochondrial inner membrane which is absent in the short isoform. [5] [6]
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References
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- ↑ Sesaki H and Jensen RE (2004) Ugo1p links the Fzo1p and Mgm1p GTPases for mitochondrial fusion. J Biol Chem 279(27):28298-303 SGD PMID 15087460
- ↑ Amutha B, et al. (2004) A novel role of Mgm1p, a dynamin-related GTPase, in ATP synthase assembly and cristae formation/maintenance. Biochem J 381(Pt 1):19-23 SGD PMID 15125685
- ↑ Sesaki H, et al. (2003) Mgm1p, a dynamin-related GTPase, is essential for fusion of the mitochondrial outer membrane. Mol Biol Cell 14(6):2342-56 SGD PMID 12808034
- ↑ Olichon A, et al. (2002) The human dynamin-related protein OPA1 is anchored to the mitochondrial inner membrane facing the inter-membrane space. FEBS Lett 523(1-3):171-6 SGD PMID 12123827
- ↑ 5.0 5.1 5.2 Herlan M, et al. (2003) Processing of Mgm1 by the rhomboid-type protease Pcp1 is required for maintenance of mitochondrial morphology and of mitochondrial DNA. J Biol Chem 278(30):27781-8 SGD PMID 12707284
- ↑ 6.0 6.1 6.2 submitted by Andreas Reichert on 2003-09-25
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