Difference between revisions of "YOR195W"

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'''Description of YOR195W:''' Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate<ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 {{SGDpaper|S000074306}} PMID 14574415</ref><ref name='S000072622'>Pfiz S, et al. (2002) The yeast kinetochore protein Slk19 is required to prevent aberrant chromosome segregation in meiosis and mitosis. Genes Cells 7(10):1033-42 {{SGDpaper|S000072622}} PMID 12354097</ref><ref name='S000069394'>Stegmeier F, et al. (2002) Separase, polo kinase, the kinetochore protein Slk19, and Spo12 function in a network that controls Cdc14 localization during early anaphase. Cell 108(2):207-20
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'''Description of YOR195W:''' Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate<ref name='S000069394'>Stegmeier F, et al. (2002) Separase, polo kinase, the kinetochore protein Slk19, and Spo12 function in a network that controls Cdc14 localization during early anaphase. Cell 108(2):207-20 {{SGDpaper|S000069394}} PMID 11832211</ref><ref name='S000072622'>Pfiz S, et al. (2002) The yeast kinetochore protein Slk19 is required to prevent aberrant chromosome segregation in meiosis and mitosis. Genes Cells 7(10):1033-42 {{SGDpaper|S000072622}} PMID 12354097</ref><ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
  {{SGDpaper|S000069394}} PMID 11832211</ref>
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  {{SGDpaper|S000074306}} PMID 14574415</ref>
 
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Revision as of 14:05, 31 March 2009

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Systematic name YOR195W
Gene name SLK19
Aliases
Feature type ORF, Verified
Coordinates Chr XV:712867..715332
Primary SGDID S000005721


Description of YOR195W: Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate[1][2][3]




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Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [3] [4]





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References

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  1. Stegmeier F, et al. (2002) Separase, polo kinase, the kinetochore protein Slk19, and Spo12 function in a network that controls Cdc14 localization during early anaphase. Cell 108(2):207-20 SGD PMID 11832211
  2. Pfiz S, et al. (2002) The yeast kinetochore protein Slk19 is required to prevent aberrant chromosome segregation in meiosis and mitosis. Genes Cells 7(10):1033-42 SGD PMID 12354097
  3. 3.0 3.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415 Cite error: Invalid <ref> tag; name "S000074306" defined multiple times with different content
  4. submitted by Jeff Ubersax on 2004-01-29

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