Difference between revisions of "YOL006C"
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| − | '''Description of YOL006C:''' Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination<ref name=' | + | '''Description of YOL006C:''' Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination<ref name='S000055801'>Thrash C, et al. (1985) Cloning, characterization, and sequence of the yeast DNA topoisomerase I gene. Proc Natl Acad Sci U S A 82(13):4374-8 {{SGDpaper|S000055801}} PMID 2989818</ref><ref name='S000065460'>Roca J (1995) The mechanisms of DNA topoisomerases. Trends Biochem Sci 20(4):156-60 {{SGDpaper|S000065460}} PMID 7770916</ref><ref name='S000074598'>Woo MH, et al. (2003) Locking the DNA topoisomerase I protein clamp inhibits DNA rotation and induces cell lethality. Proc Natl Acad Sci U S A 100(24):13767-72 |
| − | {{SGDpaper| | + | {{SGDpaper|S000074598}} PMID 14585933</ref> |
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Revision as of 13:05, 31 March 2009
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| Systematic name | YOL006C |
| Gene name | TOP1 |
| Aliases | MAK1, MAK17 |
| Feature type | ORF, Verified |
| Coordinates | Chr XV:315388..313079 |
| Primary SGDID | S000005366 |
Description of YOL006C: Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination[1][2][3]
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References
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- ↑ Thrash C, et al. (1985) Cloning, characterization, and sequence of the yeast DNA topoisomerase I gene. Proc Natl Acad Sci U S A 82(13):4374-8 SGD PMID 2989818
- ↑ Roca J (1995) The mechanisms of DNA topoisomerases. Trends Biochem Sci 20(4):156-60 SGD PMID 7770916
- ↑ Woo MH, et al. (2003) Locking the DNA topoisomerase I protein clamp inhibits DNA rotation and induces cell lethality. Proc Natl Acad Sci U S A 100(24):13767-72 SGD PMID 14585933
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