Difference between revisions of "YNL325C"

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'''Description of YNL325C:''' Protein that forms a complex with Vac14p and is involved in turnover of PI3,5P2 (phosphatidylinositol 3,5-bisphosphate) after hyperosmotic shock; required for efficient mating; member of a protein family with a domain homologous to Sac1p<ref name='S000114457'>Duex JE, et al. (2006) The Vac14p-Fig4p complex acts independently of Vac7p and couples PI3,5P2 synthesis and turnover. J Cell Biol 172(5):693-704 {{SGDpaper|S000114457}} PMID 16492811</ref><ref name='S000074437'>Rudge SA, et al. (2004) Vacuole size control: regulation of PtdIns(3,5)P2 levels by the vacuole-associated Vac14-Fig4 complex, a PtdIns(3,5)P2-specific phosphatase. Mol Biol Cell 15(1):24-36 {{SGDpaper|S000074437}} PMID 14528018</ref><ref name='S000050758'>Erdman S, et al. (1998) Pheromone-regulated genes required for yeast mating differentiation. J Cell Biol 140(3):461-83
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'''Description of YNL325C:''' Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase; required for efficient mating and response to osmotic shock; physically associates with and regulated by Vac14p; contains a SAC1-like domain<ref name='S000114457'>Duex JE, et al. (2006) The Vac14p-Fig4p complex acts independently of Vac7p and couples PI3,5P2 synthesis and turnover. J Cell Biol 172(5):693-704 {{SGDpaper|S000114457}} PMID 16492811</ref><ref name='S000074437'>Rudge SA, et al. (2004) Vacuole size control: regulation of PtdIns(3,5)P2 levels by the vacuole-associated Vac14-Fig4 complex, a PtdIns(3,5)P2-specific phosphatase. Mol Biol Cell 15(1):24-36 {{SGDpaper|S000074437}} PMID 14528018</ref><ref name='S000069689'>Gary JD, et al. (2002) Regulation of Fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by Vac7 protein and Fig4, a polyphosphoinositide phosphatase family member. Mol Biol Cell 13(4):1238-51 {{SGDpaper|S000069689}} PMID 11950935</ref><ref name='S000050758'>Erdman S, et al. (1998) Pheromone-regulated genes required for yeast mating differentiation. J Cell Biol 140(3):461-83
 
  {{SGDpaper|S000050758}} PMID 9456310</ref>
 
  {{SGDpaper|S000050758}} PMID 9456310</ref>
 
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Revision as of 07:21, 26 February 2009

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Systematic name YNL325C
Gene name FIG4
Aliases
Feature type ORF, Verified
Coordinates Chr XIV:31377..28738
Primary SGDID S000005269


Description of YNL325C: Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase; required for efficient mating and response to osmotic shock; physically associates with and regulated by Vac14p; contains a SAC1-like domain[1][2][3][4]




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References

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  1. Duex JE, et al. (2006) The Vac14p-Fig4p complex acts independently of Vac7p and couples PI3,5P2 synthesis and turnover. J Cell Biol 172(5):693-704 SGD PMID 16492811
  2. Rudge SA, et al. (2004) Vacuole size control: regulation of PtdIns(3,5)P2 levels by the vacuole-associated Vac14-Fig4 complex, a PtdIns(3,5)P2-specific phosphatase. Mol Biol Cell 15(1):24-36 SGD PMID 14528018
  3. Gary JD, et al. (2002) Regulation of Fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by Vac7 protein and Fig4, a polyphosphoinositide phosphatase family member. Mol Biol Cell 13(4):1238-51 SGD PMID 11950935
  4. Erdman S, et al. (1998) Pheromone-regulated genes required for yeast mating differentiation. J Cell Biol 140(3):461-83 SGD PMID 9456310

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