Difference between revisions of "YNL273W"
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| − | '''Description of YNL273W:''' Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase<ref name=' | + | '''Description of YNL273W:''' Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase<ref name='S000076127'>Mayer ML, et al. (2004) Identification of protein complexes required for efficient sister chromatid cohesion. Mol Biol Cell 15(4):1736-45 {{SGDpaper|S000076127}} PMID 14742714</ref><ref name='S000076989'>Xu H, et al. (2004) Mrc1 is required for sister chromatid cohesion to aid in recombination repair of spontaneous damage. Mol Cell Biol 24(16):7082-90 {{SGDpaper|S000076989}} PMID 15282308</ref><ref name='S000081067'>Nedelcheva MN, et al. (2005) Uncoupling of unwinding from DNA synthesis implies regulation of MCM helicase by Tof1/Mrc1/Csm3 checkpoint complex. J Mol Biol 347(3):509-21 {{SGDpaper|S000081067}} PMID 15755447</ref><ref name='S000073790'>Osborn AJ and Elledge SJ (2003) Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53. Genes Dev 17(14):1755-67 {{SGDpaper|S000073790}} PMID 12865299</ref><ref name='S000073860'>Katou Y, et al. (2003) S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex. Nature 424(6952):1078-83 |
| − | {{SGDpaper| | + | {{SGDpaper|S000073860}} PMID 12944972</ref> |
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Revision as of 13:05, 31 March 2009
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| Systematic name | YNL273W |
| Gene name | TOF1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XIV:122883..126599 |
| Primary SGDID | S000005217 |
Description of YNL273W: Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase[1][2][3][4][5]
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Contents
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References
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- ↑ Mayer ML, et al. (2004) Identification of protein complexes required for efficient sister chromatid cohesion. Mol Biol Cell 15(4):1736-45 SGD PMID 14742714
- ↑ Xu H, et al. (2004) Mrc1 is required for sister chromatid cohesion to aid in recombination repair of spontaneous damage. Mol Cell Biol 24(16):7082-90 SGD PMID 15282308
- ↑ Nedelcheva MN, et al. (2005) Uncoupling of unwinding from DNA synthesis implies regulation of MCM helicase by Tof1/Mrc1/Csm3 checkpoint complex. J Mol Biol 347(3):509-21 SGD PMID 15755447
- ↑ Osborn AJ and Elledge SJ (2003) Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53. Genes Dev 17(14):1755-67 SGD PMID 12865299
- ↑ Katou Y, et al. (2003) S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex. Nature 424(6952):1078-83 SGD PMID 12944972
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