Difference between revisions of "YML065W"
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| − | '''Description of YML065W:''' Largest subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; | + | '''Description of YML065W:''' Largest subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; exhibits ATPase activity<ref name='S000069533'>Bell SP (2002) The origin recognition complex: from simple origins to complex functions. Genes Dev 16(6):659-72 {{SGDpaper|S000069533}} PMID 11914271</ref><ref name='S000042829'>Klemm RD, et al. (1997) Coordinate binding of ATP and origin DNA regulates the ATPase activity of the origin recognition complex. Cell 88(4):493-502 |
| − | {{SGDpaper| | + | {{SGDpaper|S000042829}} PMID 9038340</ref> |
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Revision as of 06:21, 26 February 2009
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| Systematic name | YML065W |
| Gene name | ORC1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XIII:142210..144954 |
| Primary SGDID | S000004530 |
Description of YML065W: Largest subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; exhibits ATPase activity[1][2]
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Protein Details
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [3] [4]
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References
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- ↑ Bell SP (2002) The origin recognition complex: from simple origins to complex functions. Genes Dev 16(6):659-72 SGD PMID 11914271
- ↑ Klemm RD, et al. (1997) Coordinate binding of ATP and origin DNA regulates the ATPase activity of the origin recognition complex. Cell 88(4):493-502 SGD PMID 9038340
- ↑ Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
- ↑ submitted by Jeff Ubersax on 2004-01-29
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