Difference between revisions of "YBR179C"

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'''Description of YBR179C:''' Mitochondrial integral membrane protein involved in mitochondrial fusion and maintenance of the mitochondrial genome; contains N-terminal GTPase domain<ref name='S000052886'>Rapaport D, et al. (1998) Fzo1p is a mitochondrial outer membrane protein essential for the biogenesis of functional mitochondria in Saccharomyces cerevisiae. J Biol Chem 273(32):20150-5 {{SGDpaper|S000052886}} PMID 9685359</ref><ref name='S000045931'>Hermann GJ, et al. (1998) Mitochondrial fusion in yeast requires the transmembrane GTPase Fzo1p. J Cell Biol 143(2):359-73
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'''Description of YBR179C:''' Mitofusin, mitochondrial integral membrane protein involved in mitochondrial fusion and mitochondrial genome maintenance; contains N-terminal GTPase domain; targeted for destruction by cytosolic components of the ubiquitin-proteasome system<ref name='S000125860'>Cohen MM, et al. (2008) Ubiquitin-Proteasome-dependent Degradation of a Mitofusin, a Critical Regulator of Mitochondrial Fusion. Mol Biol Cell 19(6):2457-64 {{SGDpaper|S000125860}} PMID 18353967</ref><ref name='S000052886'>Rapaport D, et al. (1998) Fzo1p is a mitochondrial outer membrane protein essential for the biogenesis of functional mitochondria in Saccharomyces cerevisiae. J Biol Chem 273(32):20150-5 {{SGDpaper|S000052886}} PMID 9685359</ref><ref name='S000045931'>Hermann GJ, et al. (1998) Mitochondrial fusion in yeast requires the transmembrane GTPase Fzo1p. J Cell Biol 143(2):359-73
 
  {{SGDpaper|S000045931}} PMID 9786948</ref>
 
  {{SGDpaper|S000045931}} PMID 9786948</ref>
 
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Revision as of 13:05, 3 July 2008

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Systematic name YBR179C
Gene name FZO1
Aliases
Feature type ORF, Verified
Coordinates Chr II:589109..586542
Primary SGDID S000000383


Description of YBR179C: Mitofusin, mitochondrial integral membrane protein involved in mitochondrial fusion and mitochondrial genome maintenance; contains N-terminal GTPase domain; targeted for destruction by cytosolic components of the ubiquitin-proteasome system[1][2][3]




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References

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  1. Cohen MM, et al. (2008) Ubiquitin-Proteasome-dependent Degradation of a Mitofusin, a Critical Regulator of Mitochondrial Fusion. Mol Biol Cell 19(6):2457-64 SGD PMID 18353967
  2. Rapaport D, et al. (1998) Fzo1p is a mitochondrial outer membrane protein essential for the biogenesis of functional mitochondria in Saccharomyces cerevisiae. J Biol Chem 273(32):20150-5 SGD PMID 9685359
  3. Hermann GJ, et al. (1998) Mitochondrial fusion in yeast requires the transmembrane GTPase Fzo1p. J Cell Biol 143(2):359-73 SGD PMID 9786948

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