Difference between revisions of "YPL153C"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl? | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000006074 YPL153C] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''RAD53 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''RAD53 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
|nowrap| Chr XVI:264191..261726 | |nowrap| Chr XVI:264191..261726 | ||
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| + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000006074 | ||
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| − | '''Description of | + | '''Description of YPL153C:''' Protein kinase, required for cell-cycle arrest in response to DNA damage; activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p; also interacts with ARS1 and plays a role in initiation of DNA replication<ref name='S000117011'>Dohrmann PR and Sclafani RA (2006) Novel Role for Checkpoint Rad53 Protein Kinase in the Initiation of Chromosomal DNA Replication in Saccharomyces cerevisiae. Genetics 174(1):87-99 {{SGDpaper|S000117011}} PMID 16816422</ref><ref name='S000072691'>Toh GW and Lowndes NF (2003) Role of the Saccharomyces cerevisiae Rad9 protein in sensing and responding to DNA damage. Biochem Soc Trans 31(Pt 1):242-6 {{SGDpaper|S000072691}} PMID 12546694</ref><ref name='S000069936'>Schwartz MF, et al. (2002) Rad9 phosphorylation sites couple Rad53 to the Saccharomyces cerevisiae DNA damage checkpoint. Mol Cell 9(5):1055-65 |
{{SGDpaper|S000069936}} PMID 12049741</ref> | {{SGDpaper|S000069936}} PMID 12049741</ref> | ||
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J Biol Chem 278(5):3265-74</ref> | J Biol Chem 278(5):3265-74</ref> | ||
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Revision as of 07:46, 27 February 2007
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| Systematic name | YPL153C |
| Gene name | RAD53 |
| Aliases | LSD1, MEC2, SPK1 |
| Feature type | ORF, Verified |
| Coordinates | Chr XVI:264191..261726 |
| Primary SGDID | S000006074 |
Description of YPL153C: Protein kinase, required for cell-cycle arrest in response to DNA damage; activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p; also interacts with ARS1 and plays a role in initiation of DNA replication[1][2][3]
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References
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- ↑ Dohrmann PR and Sclafani RA (2006) Novel Role for Checkpoint Rad53 Protein Kinase in the Initiation of Chromosomal DNA Replication in Saccharomyces cerevisiae. Genetics 174(1):87-99 SGD PMID 16816422
- ↑ Toh GW and Lowndes NF (2003) Role of the Saccharomyces cerevisiae Rad9 protein in sensing and responding to DNA damage. Biochem Soc Trans 31(Pt 1):242-6 SGD PMID 12546694
- ↑ Schwartz MF, et al. (2002) Rad9 phosphorylation sites couple Rad53 to the Saccharomyces cerevisiae DNA damage checkpoint. Mol Cell 9(5):1055-65 SGD PMID 12049741
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