Positions in yeast labs

Postdoctoral Fellowship in yeast evolutionary genomics at Stanford University

The Fraser Lab in the Department of Biology is seeking a postdoctoral fellow to work on the evolution of gene expression in Saccharomyces yeast. The exact subject is flexible, but will likely involve using RNA-seq to answer fundamental questions about the mechanisms and consequences of gene expression evolution- especially in cases of evolutionary adaptations. The ideal candidate would have experience in yeast molecular biology techniques, as well as some familiarity with computational and/or evolutionary analysis. Salary and benefits are both above the NIH standards for postdocs. Please email a cover letter and CV to hbfraser[at]stanford[dot]edu.

Research Associate position (Ph.D. level) at Stanford University

The Fraser Lab in the Department of Biology is seeking a Basic Life Science Research Associate (Ph.D. level). We apply the exciting tools of genomics and high-throughput sequencing to study the evolution of gene expression in a variety of species, but primarily budding yeast. Duties will include:

• Performing a wide range of experiments with the yeast S. cerevisiae. These will focus on a revolutionary new tool in molecular biology: genetic engineering via the CRISPR/Cas system. Other experiments will include gene knockout/replacement, chromatin immunoprecipitation, and high-throughput sequencing of mRNA. • Teaching experimental protocols to others in the lab • Keeping the lab's yeast strains/chemicals organized • Overseeing an undergraduate student for dishwashing/media preparation

A Ph.D. in a Biology-related field is required, with at least 2 years spent working with S. cerevisiae. Also desirable (but not required) is experience with: mammalian cell culture, chromatin immunoprecipitation, and/or high-throughput sequencing. Please email a cover letter and CV to hbfraser[at]stanford[dot]edu.

Postdoctoral fellowship in cell cycle evolution at the Institute of Genetics and Development of Rennes, France

A three-year post-doctoral position supported by a starting grant from the European Research Council (ERC) is available in the group of Dr. Damien Coudreuse at the Institute of Genetics and Development of Rennes (IGDR), France (http://igdr.univ-rennes1.fr/english/). Research in this laboratory takes a synthetic biology approach in fission yeast to study the architecture and evolution of cell cycle regulation. The proposed project aims at understanding fundamental aspects of the evolution of cell proliferation, from how cells overcome external challenges to common features of independent evolutionary processes. It will be based on the use of fission yeast cells operating with various minimal cell cycle control circuits as starting points for experimental evolution approaches. Candidates should contact Dr. Damien Coudreuse at damien.coudreuse@univ-rennes1.fr and send a Curriculum Vitae, including past research experiences and publication records, as well as a letter detailing their motivation and interest in our work. Applicants should also request recommendation letters to be directly sent by two or three references.

Postdoctoral Fellowship in Cell Fate and Gene Regulation (POS00123), LRI/Crick Institute, London, UK

We seek a talented and motivated Postdoc to join the Cell Fate and Gene Regulation Laboratory in London, UK. The Cell Fate and Gene Regulation laboratory headed by Dr Folkert van Werven will be opened in the fall of this year. It will be a small, highly interactive, international research group that focuses on understanding the molecular mechanisms of how cell fate decisions are controlled. Initially we will use budding yeast as a model system, and take molecular, systematic and quantitative approaches (including single-molecule, proteomic, and genomic techniques) to study this problem. For more information please send an email (Folkert.vanWerven at cancer.org.uk) or go to: https://cruk.taleo.net/careersection/cruk_corporate/jobdetail.ftl?lang=en&job=POS00123&view=rss

Postdoctoral Position in Chemical Genomics at RIKEN Advance Science Institute, Tokyo, Japan

We are accepting applications for a postdoctoral position at the RIKEN Advance Science Institute to work with yeast chemical genomics systems to characterize the targets of novel natural products from a large compound library using a diverse set of genomic and biochemical tools. The position is for a minimum of 1 year starting 4/2013 and renewable. Details on the research team can be found here: http://www.riken.jp/ChemicalGenomics/Target_E.html. Salary is competitive with benefits. The successful candidate will work with the Molecular Ligand Target research team, headed by Dr. Charlie Boone within the Chemical Biology Department of Dr. Hiroyuki Osada. For more information please contact Dr. Jeff Piotrowski (j.piotrowski_at_riken.jp) or Dr. Charlie Boone (charlie.boone_at_utoronto.ca) for more details

Post-doctoral Research Associate in Cell Biology at University of Tennessee at Knoxville

A post-doctoral fellow position is available starting January 2013 in the lab of Dr. Maitreyi Das, Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville. Research in this lab is focused on cell polarity using fission yeast (S. pombe) as a model organism. The project will involve understanding fundamental processes that regulate polarized cell growth, especially higher-order molecular networks that are controlled both spatially and temporally. To achieve this single-cell systems biology with a combination of experimental and quantitative imaging approaches will be used. For more details please see the following link, http://web.bio.utk.edu/bcmb/faculty/Individual_Faculty_Pages/Das_Maitreyi/Das_Maitreyi.html. Qualifications: Candidate should have a PhD degree. Major techniques required for the success of this project are yeast cell biology and microscopy. An ideal candidate should have expertise in all or any of these techniques. Motivated candidates should submit their updated curriculum vitae including past research experience and list of publications, a statement of research interests, and the contact information for at least 3 references to mdas@utk.edu.

Postdoctoral Position in Biology of Yeast Colonies at Charles University in Prague, Czech Republic

Postdoctoral positions are available in the lab of Zdena Palkova (http://www.natur.cuni.cz/~zdenap). The Research Group is interested in different aspects of yeast multicellularity including questions related to topics of yeast cell differentiation, ageing, stress defense, adaptation and longevity that are crucial in any organism, including humans.

Selected recent references: • Cap M, Stepanek L, Harant K, Vachova L, Palkova Z. (2012) Cell differentiation within a yeast colony: metabolic and regulatory parallels with a tumor-affected organism. Mol Cell 46: 436-448 • Vachova L, Stovicek V, Hlavacek O, Chernyavskiy O, Stepanek L, Kubinová L, Palkova Z. (2011) Flo11p, drug efflux pumps, and the extracellular matrix cooperate to form biofilm yeast colonies. J Cell Biol. 194: 679-87.

Candidates should have experience in molecular and cellular biology and methodical knowledge in techniques of yeast cell growth and manipulation. In addition, candidates should have high motivation and ability to work independently and take responsibility for his/her own project as well as to work in a team.

The applicants should have (i) a recent PhD (the degree obtained no earlier than on 28th of March 2008), (ii) promising publication record and be able to speak fluent English (or Czech). Please send your motivation letter (<500 words), CV, list of publications (including IF and the number of citations) and contact information of three references directly to the group leader Zdena Palkova, mailto:zdenap@natur.cuni.cz (please combine all documents into single PDF file). Applications will be considered until suitable candidates are found. The positions include additional funds for the international mobility (3 months).

Laboratory Manager in Molecular Biology at Brown University

March 2012: Position available in the laboratory of Tricia Serio, Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI

The Laboratory Manager will have primary responsibility for managing the daily operation of the laboratory and for designing, conducting, and analyzing experiments to investigate cellular control of prion propagation in the yeast S. cerevisiae. The Laboratory Manager will also oversee and coordinate the activities of other laboratory personnel and the move of our laboratory to the Department of Molecular and Cell Biology, University of Arizona, Tucson, AZ during the summer of 2012. The position will continue at the UA.

Position requirements: • MA, MS, or PhD in molecular biology, genetics, cell biology, biochemistry or related field • 3-5 years full-time laboratory experience • Competence in laboratory techniques such as DNA isolation and cloning, PCR, RNA isolation, RT-PCR, protein isolation/purification, gel electrophoresis, western blotting, immunoprecipitation, fluorescence imaging and quantitative microscopy techniques including FRAP and FLIP); experience with yeast preferred but not required • Excellent organizational/record-keeping skills • Excellent hand/eye coordination • Excellent interpersonal skills • Competence with computer programs such as FileMaker, Microsoft Word and Excel, Adobe Photoshop and Illustrator • Excellent quantitative skills • Self-motivated

Applications should be submitted through Human Resources at Brown University: https://careers.brown.edu/applicants/jsp/shared/frameset/Frameset.jsp?time=1332257367295 position # M02626

PhD student in Molecular Biology (Marie Curie Early Stage Researcher)at the University of Gothenburg, Sweden

A PhD student position in Molecular Biology/Systems Biology is available in the lab of Prof. Stefan Hohmann, Dept of Cell and Molecular Biology, University of Gothenburg, Sweden.

The research project “Experimental investigation of the yeast Hxk2/Snf1/Mig1 network” aims to understand the dynamic control of the Hxk2/Snf1/Mig1 glucose signalling pathway employing single cell technology developed in the ISOLATE project. Here the experimental platform generated in the project will be optimized, especially the formation of cell arrays of synchronized cells as well as image analysis. Using in parallel Mig1 and Msn2 reporters, response thresholds under different glucose levels will be establish and effects on cell-to-cell variability and bistability will be determined.

Requested Background(advantageous but not required): Yeast biology, yeast genetics, glucose signalling, use of microfluidic devices, microscopy, image analysis, application of nano-sensor technology, ‘systems’ thinking.

The Marie Curie project ISOLATE is a collaborative research and training network between eight partners, incl. in different European countries. The PhD students and postdocs in the project will perform top-notch research and will additionally benefit from an excellent training network offered by the project partners. Research stays during the PhD projects in other partners’ labs are strongly encouraged. Primarily recruitment of researchers from EC Member States and associated countries, but also open to researchers from third countries. Researchers are normally required to move from one country to another when taking up the appointment.

Please send an application including (1) a max. one-page cover letter containing a justification why this position was chosen as well as a career vision statement, (2) a complete CV with details on education, previous research activities and a list of publications (if any,)(3) a copy of the passport or ID with picture, (4) two letters of recommendation, to maria.enge@gu.se (Project Manager in Prof. Hohmann's group).

PhD student in Systems Biology (Marie Curie Early Stage Researcher)at the University of Gothenburg, Sweden

A PhD student position in Systems Biology is available in the lab of Prof. Stefan Hohmann, Dept of Cell and Molecular Biology, University of Gothenburg, Sweden.

The research project “Theoretical investigation of the yeast Hxk2/Snf1/Mig1 network” aims to understand the dynamic control of the Hxk2/Snf1/Mig1 glucose signalling pathway employing single cell technology developed in the ISOLATE project. Data generated in the project will be interpreted by mathematical modelling together with other project partners to understand feedback and feed-forward mechanisms of signalling. Mutants and inhibitory compounds will be used to test how those affect thresholds and bistability. The analysis will reveal the genetic determination of the system properties, how they are regulated and how robustness against perturbation is established.

Requested Background(advantageous but not required): Yeast biology, yeast genetics, glucose signaling, microscopy, image analysis, development of mathematical models, ‘systems’ thinking.

The Marie Curie project ISOLATE is a collaborative research and training network between eight partners, incl. in different European countries. The PhD students and postdocs in the project will perform top-notch research and will additionally benefit from an excellent training network offered by the project partners. Research stays during the PhD projects in other partners’ labs are strongly encouraged. Primarily recruitment of researchers from EC Member States and associated countries, but also open to researchers from third countries. Researchers are normally required to move from one country to another when taking up the appointment.

Please send an application including (1) a max. one-page cover letter containing a justification why this position was chosen as well as a career vision statement, (2) a complete CV with details on education, previous research activities and a list of publications (if any,)(3) a copy of the passport or ID with picture, (4) two letters of recommendation, to maria.enge@gu.se (Project Manager in Prof. Hohmann's group).

Postdoctoral position to study Ty1 retrotransposition at the University of Georgia

A postdoctoral position is available in the lab of David J. Garfinkel, Department of Biochemistry and Molecular Biology, University of Georgia, Athens GA to work on the retrovirus-like transposon Ty1 of Saccharomyces. Specifically, we are investigating a new form of RNA-interference based on Ty1 antisense RNAs that acts posttranslationally and targets Ty1 proteins in the absence of the conserved RNAi pathways.

Experience in molecular genetics, protein/nucleic acid interactions or cytology would be helpful.

Also see our website for further information [1]

Please send resume or inquiries to:

David J. Garfinkel
Department of Biochemistry and Molecular Biology
A130 Life Sciences
120 Green St.
University of Georgia
Athens, GA 30622

tel: 706-542-9403
djgarf@bmb.uga.edu

Yeast Systems Biology Position at Virginia Tech (Research Associate or Sr Research Associate)

The Synthetic Biology group at Virginia Bioinformatics Institute (VBI) is involved in two collaborative research projects focused on the development of mathematical models of gene-protein regulatory networks controlling cell growth and division. Temporal organization of the budding yeast cell cycle has been studied from two vantage points: bottom-up models emphasize a protein regulatory network centered around cyclin-dependent protein kinases, whereas top-down models focus on a gene regulatory network governed by interrelated transcription factors. The first project is focused on unifying these two perspectives. The second project is focused on the development of stochastic models of the regulatory network controlling the cell cycle. Both projects are performed in close collaboration with experts in computer science, data mining, bioinformatics, and mathematical modeling. The successful candidate will be expected to contribute significantly to these two projects by being responsible for designing and performing experiments used to validate model predictions. These experiments will involve the development of a new collection of cell cycle mutants and their quantitative characterization by time-lapse microscopy. In addition, the successful candidate will be expected to prepare the results for publication and presentation, to help supervise graduate and undergraduate students, and to contribute to grant proposals.

Dependent on the qualifications of the successful candidate, the position will hold the research faculty rank of either Research Associate or Senior Research Associate.

Go to the position description for additional information and for submitting applications.

More information about our team can be found by visiting:

• Jean Peccoud's home page
• John Tyson's home page
• T.M. Murali's home page

Postdoctoral position - Laboratory of Cell Physics - Strasbourg, France

Postdoctoral position is available in the Laboratory of Cell Physics, ISIS/IGBMC, Strasbourg, France. The project will focus on the dynamics of the cytokinetic ring in the fission yeast S. pombe. The roles of the Rho GTPase, actin polymerisation, and myosin will be studied. The work will involve genetics, cell biology, microscopy, microfabrication and microfluidics; for more information, send a CV and contact information of referees to Dr. Daniel Riveline (riveline@unistra.fr)

==Postdoctoral Position in Quantitative Systems Biology A postdoctoral fellow position is immediately available for a highly motivated recent PhD or MD/PhD graduate in biomedical science in the lab of Dr. Gregor Neuert at Vanderbilt University School of Medicine in Nashville, Tennessee.

The main interests of the group focus on quantitative understanding of signaling and gene regulatory processes of coding and non-coding RNA in single cells at single molecule resolution. Our research methods include a combination of single-cell experimental and computational techniques as well as molecular biology and yeast genetics.

We are seeking highly motivated and curious applicants with strong background in yeast genetics, molecular biology and computational biology. Background in microscopy and computational modeling is also considered a plus but not required.

We offer a highly interactive, international and interdisciplinary research environment with strong mentoring and career development support. Vanderbilt University School of Medicine is ranked #9 in NIH funding and #15 in U.S. News medical school ranking and is equipped with world-class cutting-edge core facilities.

Selected publications: Neuert, Munsky et al. Science 2013 ; Munsky, Neuert et al. Science 2012; Bumgarner, Neuert et al. Mol.Cell 2012; Van Werven, Neuert et al. Cell 2013

Interested applicants should send curriculum vitae, a summary of research experience and accomplishments, and contact information of 2-3 references to gregor.neuert@vanderbilt.edu.

For more information please visit: https://www.mc.vanderbilt.edu/root/vumc.php?site=neuertlab