Positions in yeast labs

Postdoctoral Position in Chemical Genomics at RIKEN Advance Science Institute, Tokyo, Japan

We are accepting applications for a postdoctoral position at the RIKEN Advance Science Institute to work with yeast chemical genomics systems to characterize the targets of novel natural products from a large compound library using a diverse set of genomic and biochemical tools. The position is for a minimum of 1 year starting 4/2013 and renewable. Details on the research team can be found here: http://www.riken.jp/ChemicalGenomics/Target_E.html. Salary is competitive with benefits. The successful candidate will work with the Molecular Ligand Target research team, headed by Dr. Charlie Boone within the Chemical Biology Department of Dr. Hiroyuki Osada. For more information please contact Dr. Jeff Piotrowski (j.piotrowski_at_riken.jp) or Dr. Charlie Boone (charlie.boone_at_utoronto.ca) for more details

2-year postdoctoral position at the Institute of Genetics and Development of Rennes (IGDR), France

A 2-year postdoctoral position is open in the newly established team of Gwenaël Rabut at the Institute of Genetics and Development of Rennes (IGDR), France (http://igdr.univ-rennes1.fr/english/). Our team investigates the molecular functions of ubiquitin and ubiquitin-like protein modifiers, particularly focusing on the regulation of nuclear processes such as DNA replication and DNA repair. We are studying these functions in budding yeast, using a combination of complimentary biochemical and genetic approaches as well as advanced light microscopy and mass spectrometry.

We are seeking highly motivated candidates with a strong background in molecular biology and biochemistry. Those experienced in mass spectrometry or genetics are encouraged to apply. We also welcome applicants with expertise in advanced light microscopy or multidisciplinary approaches.

The Institute of Genetics and Development of Rennes is dynamic and expanding, with 20 senior and junior groups addressing a wide range of subjects in cell biology in a multidisciplinary environment. It benefits from excellent core facilities, such as state-of-the-art microscopy and genomics centers.

Rennes is a lively city located in the North-West of France, with fast and direct access to Paris (2 hours by train). Its rich student life, its strong music and food heritage and its proximity to the coast make it a very welcoming and pleasant place to live.

Candidates should send their CV and a letter of motivation to Gwenaël Rabut (gwenael.rabut@inserm.fr) and provide the name and contact details of at least two references.

Post-doctoral Research Associate in Cell Biology at University of Tennessee at Knoxville

A post-doctoral fellow position is available starting January 2013 in the lab of Dr. Maitreyi Das, Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville. Research in this lab is focused on cell polarity using fission yeast (S. pombe) as a model organism. The project will involve understanding fundamental processes that regulate polarized cell growth, especially higher-order molecular networks that are controlled both spatially and temporally. To achieve this single-cell systems biology with a combination of experimental and quantitative imaging approaches will be used. For more details please see the following link, http://web.bio.utk.edu/bcmb/faculty/Individual_Faculty_Pages/Das_Maitreyi/Das_Maitreyi.html. Qualifications: Candidate should have a PhD degree. Major techniques required for the success of this project are yeast cell biology and microscopy. An ideal candidate should have expertise in all or any of these techniques. Motivated candidates should submit their updated curriculum vitae including past research experience and list of publications, a statement of research interests, and the contact information for at least 3 references to mdas@utk.edu.

1 Year Technician Position in Yeast Lab at the MRC National Institute for Medical Research in London

We are looking to recruit a Research Technician to work in the research group of Peter Thorpe in the Division of Stem Cell Biology. http://www.nimr.mrc.ac.uk/research/peter-thorpe/

As a Research Technician you will possess a degree or equivalent in chemistry, biology, or biotechnologies, have prior laboratory experience and potentially some experience working with yeast.

Along with a confidence with basic molecular biology and computational data analysis you should be able to plan your work efficiently to meet deadlines and be meticulous in keeping accurate records. You will be expected to prepare and present your results both in written form and orally. You will have good communication skills and will be expected to integrate into a team, working closely with your colleagues.

You will be confident using standard computer software, including Microsoft office and you may have experience handling large datasets. Specialist training to support the development of skills will be given where necessary. For more details see http://www.nature.com/naturejobs/science/jobs/282634-Research-Technician-1-year-fixed-term

Applications are handled by the RCUK Shared Services Centre; to apply please visit our job board at http://www.topcareer.jobs/Vacancy/irc65811_2224.aspx. If you are unable to apply online please contact us on 01793 867003 quoting reference IRC65811.

Closing date: 28th September 2012

Postdoctoral Position in Biology of Yeast Colonies at Charles University in Prague, Czech Republic

Postdoctoral positions are available in the lab of Zdena Palkova (http://www.natur.cuni.cz/~zdenap). The Research Group is interested in different aspects of yeast multicellularity including questions related to topics of yeast cell differentiation, ageing, stress defense, adaptation and longevity that are crucial in any organism, including humans.

Selected recent references: • Cap M, Stepanek L, Harant K, Vachova L, Palkova Z. (2012) Cell differentiation within a yeast colony: metabolic and regulatory parallels with a tumor-affected organism. Mol Cell 46: 436-448 • Vachova L, Stovicek V, Hlavacek O, Chernyavskiy O, Stepanek L, Kubinová L, Palkova Z. (2011) Flo11p, drug efflux pumps, and the extracellular matrix cooperate to form biofilm yeast colonies. J Cell Biol. 194: 679-87.

Candidates should have experience in molecular and cellular biology and methodical knowledge in techniques of yeast cell growth and manipulation. In addition, candidates should have high motivation and ability to work independently and take responsibility for his/her own project as well as to work in a team.

The applicants should have (i) a recent PhD (the degree obtained no earlier than on 28th of March 2008), (ii) promising publication record and be able to speak fluent English (or Czech). Please send your motivation letter (<500 words), CV, list of publications (including IF and the number of citations) and contact information of three references directly to the group leader Zdena Palkova, mailto:zdenap@natur.cuni.cz (please combine all documents into single PDF file). Applications will be considered until suitable candidates are found. The positions include additional funds for the international mobility (3 months).

Laboratory Manager in Molecular Biology at Brown University

March 2012: Position available in the laboratory of Tricia Serio, Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI

The Laboratory Manager will have primary responsibility for managing the daily operation of the laboratory and for designing, conducting, and analyzing experiments to investigate cellular control of prion propagation in the yeast S. cerevisiae. The Laboratory Manager will also oversee and coordinate the activities of other laboratory personnel and the move of our laboratory to the Department of Molecular and Cell Biology, University of Arizona, Tucson, AZ during the summer of 2012. The position will continue at the UA.

Position requirements: • MA, MS, or PhD in molecular biology, genetics, cell biology, biochemistry or related field • 3-5 years full-time laboratory experience • Competence in laboratory techniques such as DNA isolation and cloning, PCR, RNA isolation, RT-PCR, protein isolation/purification, gel electrophoresis, western blotting, immunoprecipitation, fluorescence imaging and quantitative microscopy techniques including FRAP and FLIP); experience with yeast preferred but not required • Excellent organizational/record-keeping skills • Excellent hand/eye coordination • Excellent interpersonal skills • Competence with computer programs such as FileMaker, Microsoft Word and Excel, Adobe Photoshop and Illustrator • Excellent quantitative skills • Self-motivated

Applications should be submitted through Human Resources at Brown University: https://careers.brown.edu/applicants/jsp/shared/frameset/Frameset.jsp?time=1332257367295 position # M02626

PhD student in Molecular Biology (Marie Curie Early Stage Researcher)at the University of Gothenburg, Sweden

A PhD student position in Molecular Biology/Systems Biology is available in the lab of Prof. Stefan Hohmann, Dept of Cell and Molecular Biology, University of Gothenburg, Sweden.

The research project “Experimental investigation of the yeast Hxk2/Snf1/Mig1 network” aims to understand the dynamic control of the Hxk2/Snf1/Mig1 glucose signalling pathway employing single cell technology developed in the ISOLATE project. Here the experimental platform generated in the project will be optimized, especially the formation of cell arrays of synchronized cells as well as image analysis. Using in parallel Mig1 and Msn2 reporters, response thresholds under different glucose levels will be establish and effects on cell-to-cell variability and bistability will be determined.

Requested Background(advantageous but not required): Yeast biology, yeast genetics, glucose signalling, use of microfluidic devices, microscopy, image analysis, application of nano-sensor technology, ‘systems’ thinking.

The Marie Curie project ISOLATE is a collaborative research and training network between eight partners, incl. in different European countries. The PhD students and postdocs in the project will perform top-notch research and will additionally benefit from an excellent training network offered by the project partners. Research stays during the PhD projects in other partners’ labs are strongly encouraged. Primarily recruitment of researchers from EC Member States and associated countries, but also open to researchers from third countries. Researchers are normally required to move from one country to another when taking up the appointment.

Please send an application including (1) a max. one-page cover letter containing a justification why this position was chosen as well as a career vision statement, (2) a complete CV with details on education, previous research activities and a list of publications (if any,)(3) a copy of the passport or ID with picture, (4) two letters of recommendation, to maria.enge@gu.se (Project Manager in Prof. Hohmann's group).

PhD student in Systems Biology (Marie Curie Early Stage Researcher)at the University of Gothenburg, Sweden

A PhD student position in Systems Biology is available in the lab of Prof. Stefan Hohmann, Dept of Cell and Molecular Biology, University of Gothenburg, Sweden.

The research project “Theoretical investigation of the yeast Hxk2/Snf1/Mig1 network” aims to understand the dynamic control of the Hxk2/Snf1/Mig1 glucose signalling pathway employing single cell technology developed in the ISOLATE project. Data generated in the project will be interpreted by mathematical modelling together with other project partners to understand feedback and feed-forward mechanisms of signalling. Mutants and inhibitory compounds will be used to test how those affect thresholds and bistability. The analysis will reveal the genetic determination of the system properties, how they are regulated and how robustness against perturbation is established.

Requested Background(advantageous but not required): Yeast biology, yeast genetics, glucose signaling, microscopy, image analysis, development of mathematical models, ‘systems’ thinking.

The Marie Curie project ISOLATE is a collaborative research and training network between eight partners, incl. in different European countries. The PhD students and postdocs in the project will perform top-notch research and will additionally benefit from an excellent training network offered by the project partners. Research stays during the PhD projects in other partners’ labs are strongly encouraged. Primarily recruitment of researchers from EC Member States and associated countries, but also open to researchers from third countries. Researchers are normally required to move from one country to another when taking up the appointment.

Please send an application including (1) a max. one-page cover letter containing a justification why this position was chosen as well as a career vision statement, (2) a complete CV with details on education, previous research activities and a list of publications (if any,)(3) a copy of the passport or ID with picture, (4) two letters of recommendation, to maria.enge@gu.se (Project Manager in Prof. Hohmann's group).

Postdoctoral position to study Ty1 retrotransposition at the University of Georgia

A postdoctoral position is available in the lab of David J. Garfinkel, Department of Biochemistry and Molecular Biology, University of Georgia, Athens GA to work on the retrovirus-like transposon Ty1 of Saccharomyces. Specifically, we are investigating a new form of RNA-interference based on Ty1 antisense RNAs that acts posttranslationally and targets Ty1 proteins in the absence of the conserved RNAi pathways.

Experience in molecular genetics, protein/nucleic acid interactions or cytology would be helpful.

Also see our website for further information [1]

Please send resume or inquiries to:

David J. Garfinkel

Department of Biochemistry and Molecular Biology

A130 Life Sciences

120 Green St.

University of Georgia

Athens, GA 30622

tel: 706-542-9403

djgarf@bmb.uga.edu

Yeast Systems Biology Position at Virginia Tech (Research Associate or Sr Research Associate)

The Synthetic Biology group at Virginia Bioinformatics Institute (VBI) is involved in two collaborative research projects focused on the development of mathematical models of gene-protein regulatory networks controlling cell growth and division. Temporal organization of the budding yeast cell cycle has been studied from two vantage points: bottom-up models emphasize a protein regulatory network centered around cyclin-dependent protein kinases, whereas top-down models focus on a gene regulatory network governed by interrelated transcription factors. The first project is focused on unifying these two perspectives. The second project is focused on the development of stochastic models of the regulatory network controlling the cell cycle. Both projects are performed in close collaboration with experts in computer science, data mining, bioinformatics, and mathematical modeling. The successful candidate will be expected to contribute significantly to these two projects by being responsible for designing and performing experiments used to validate model predictions. These experiments will involve the development of a new collection of cell cycle mutants and their quantitative characterization by time-lapse microscopy. In addition, the successful candidate will be expected to prepare the results for publication and presentation, to help supervise graduate and undergraduate students, and to contribute to grant proposals.

Dependent on the qualifications of the successful candidate, the position will hold the research faculty rank of either Research Associate or Senior Research Associate.

Go to the position description for additional information and for submitting applications.

More information about our team can be found by visiting:

• Jean Peccoud's home page
• John Tyson's home page
• T.M. Murali's home page

Postdoctoral grants at the Max Planck Institute for Evolutionary Biology, Plön, Germany

Post-doctoral grants are available for ambitious, motivated scientists to join Experimental Evolution Research Group. We can provide excellent research funding and support for projects that build on or complement our existing program. Positions are funded by the Max Planck Society for 2 years initially.

We use Saccharomyces yeasts as model organisms for evolution and ecology. ­ Saccharomyces cerevisiae is probably the best known and most tractable model organism used in biology, but its life outside the laboratory is poorly understood. We study the evolution of various interesting yeast traits using both laboratory experiments and observations of wild yeast. For a primer on yeast evolutionary biology, and to understand the motivation for our research please read Greig, D. & Leu, J-Y. (2009) “Natural history of budding yeast” Curr. Biol. 19:R886-890. For our current work, please see our lab web page

The Max Planck Institute for Evolutionary Biology offers outstanding infrastructure and facilities, and is attractively located in Northern Germany, in a lake district near the Baltic coast. It is well connected by train to the university towns of Lübeck and Kiel, and Hamburg is the nearest major airport.

Applicants must have a PhD and at least one peer-reviewed publication in the field of evolution, ecology, or yeast genetics. Applicants should prepare a short (<500 word) research proposal, a CV, and contact details for three academic referees. They should combine these into a single PDF file and send it by email to Duncan Greig (d.greig@evolbio.mpg.de). Informal enquiries can be made to any member of the Research Group. Applications will be considered until suitable candidates are found. September 2011

Postdoctoral position

SEPTEMBER 2011: A postdoctoral position is available in the laboratory of Claudio Joazeiro, Department of Cell Biology, The Scripps Research Institute (San Diego, California).

Research in the laboratory addresses the function of E3 ubiquitin ligases in biology and disease.

The position available is to elucidate the functions and mechanisms of the E3 ligase LISTERIN. We had previously reported on a new mouse model of neurodegeneration caused by mutation of Listerin/Ltn1, a novel E3 (Chu et al. 2009). Homozygous mutant mice exhibit profound early-onset and progressive neurological and motor dysfunction. The focus of our most recent work has been on elucidating this E3’s critical biological role(s) and determining how defects in its function lead to the disease. Listerin/Ltn1 is conserved in all eukaryotes, so we have taken advantage of budding yeast and found that the E3 is ribosome-associated and functions in the quality control of a specific subset of aberrant, nascent proteins (Bengtson & Joazeiro 2010). Currently, we undertake biochemistry, yeast genetics, mammalian tissue culture and genomic approaches to continue our characterization of Listerin/Ltn1, and are positioned to readily test the relevance of the discoveries we make for neurodegeneration using the mouse model. There are opportunities for studies along any of the above research lines, depending on the background and interests of the applicant.

Selected references:

• Bengtson MH & Joazeiro CA. 2010. Role of a ribosome-associated E3 ubiquitin ligase in protein quality control. Nature 467:470-3.
• Deshaies RJ & Joazeiro CA. 2009. RING domain E3 ubiquitin ligases. Annu Rev Biochem. 78:399-434.
• Chu J et al. 2009. A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration. PNAS 106:2097-103.

The candidate should be independent, hard working, proactive and productive, and should have strong conceptual and experimental background in biochemistry and molecular biology.

Please send CV, a 1-page statement of current and future research interests, and the names and contact information of three references to:
Claudio Joazeiro
c/o Miriam Berba (Email: mirberba@scripps.edu)
The Scripps Research Institute, CB-163
10550 N Torrey Pines Rd
La Jolla, CA 92037 USA

Postdoctoral position - Laboratory of Cell Physics - Strasbourg, France

Postdoctoral position is available in the Laboratory of Cell Physics, ISIS/IGBMC, Strasbourg, France. The project will focus on the dynamics of the cytokinetic ring in the fission yeast S. pombe. The roles of the Rho GTPase, actin polymerisation, and myosin will be studied. The work will involve genetics, cell biology, microscopy, microfabrication and microfluidics; for more information, send a CV and contact information of referees to Dr. Daniel Riveline (riveline@unistra.fr)

1 one . Postdoctoral position at Rio de Janeiro, Brazil

Laboratory of yeast molecular biology. Mónica Montero Lomelí Instituto de Bioquimica Medica.Programa de Biologia Molecular e Biotecnologia.Universidade Federal do Rio de Janeiro.Rio de Janerio, Brazil. http://yeastworld.wordpress.com

Our group is interested in the potential use of Yarrowia lipolytica, as work-horse for biotechnological applications. The position available is to design a platform for gene deletion and heterologous expression of proteins in a wild type strain.. We had previously reported a rapid high throughput method to study lipid droplet dynamics in the known yeast Saccharomyces cerevisiae Bozaquel-Morais BL, PLoS One. 2010 Oct 28;5(10):e13692) . The focus of our most recent work is to study the signaling mechanisms that alter the accumulation of lipid droplets in yeast, using S. cerevisiae, Yarrowia lipolytica and Usitlago maydis. We use biochemistry, yeast genetics, microarray and systems biology approaches. Depending on the background and interest of the applicant we offer opportunity to study Yarrowia lipolytica and join the other research projects. The fellowship is renewable for three years and can start as soon as March 2013. The candidate should be independent, with strong background in biochemistry, yeast genetics and molecular biology, and no more than 5 years of receiving the PhD degree. Please send to montero@bioqmed.ufrj.br, monterolomeli@hotmail.com before January 7, 2013 the following all in a single PDF file: 1. CV 2. one-page motivation letter with your research interests, 3. and the names and contact information of three references

Postdoctoral Position Available in Systems Biology at E&J Gallo Winery, Modesto, CA

We are accepting applications for a postdoctoral position to work with yeast and grape metabolic systems. Using a diverse set of computational biology, molecular biology, biochemistry, microbiology and wine fermentation we seek to develop cost-effective, efficient processes that deliver the best quality wine to the consumer. The successful candidate will work on a cross-functional team using transcriptomics, functional genomics, metabolomics and mathematical modeling to understand and predict the production of specific molecules known to be quality attributes in grape and wine.

There is science and there is art; at E&J Gallo, the world’s largest and most successful family-owned winery, we have it all. If you are looking for a diverse workplace filled with energy, enthusiasm, innovation and a love for wine then E&J Gallo Winery is the place for you. To learn more about this exciting and unique opportunity to incorporate your scientific skills with state of the art industrial processes please see the following link.

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Postdoctoral Position Combining Genomics and Proteomics at West Virginia University

One postdoctoral position is available in genomics and proteomics lab at West Virginia University. Research uses the natural genetic variation in S. cerevisiae to uncover the genetic basis of phenotypic variation in response to environmental toxins using classical genetics, next generation sequencing of genomes and transcriptomes, whole-cell proteomics and mapping of post-translational modifications. The Biology Department houses the WVU Genome Center and the mass spec facilities are housed in the Shared Research Facilities. The minimum requirements are a Ph.D. in biology/ genetics/ biochemistry/ bioinformatics or related area, excellent oral and written communication skills, and demonstrated ability to work effectively with others. Strong bioinformatic skills are also highly desirable. Applications will be reviewed beginning March 15, 2013*, continuing until the position is filled. Start date as early as May 3013. The position is subject to annual review and may extend up to three years contingent upon performance and funding. Please email a CV with contact information for three references and a brief summary of research interests to Dr. Gallagher at jennifer.gallagher@mail.wvu.edu WVU is an Affirmative Action/Equal Opportunity employer and the recipient of an NSF ADVANCE award for gender equity. WVU is located in Morgantown, WV which is three hours west of Washington, DC and 1 1/2 hours south of Pittsburgh, PA. The Biology Department is located in the Downtown Campus of Morgantown, WV. WVU is an Affirmative Action/Equal Opportunity employer and the recipient of an NSF ADVANCE award for gender equity.