Difference between revisions of "YML061C"
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| − | '''Description of YML061C:''' DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis<ref name='S000046554'>Foury F and Lahaye A (1987) Cloning and sequencing of the PIF gene involved in repair and recombination of yeast mitochondrial DNA. EMBO J 6(5):1441-9 {{SGDpaper|S000046554}} PMID 3038524</ref><ref name='S000136719'>Guirola M, et al. (2010) Lack of DNA helicase Pif1 disrupts zinc and iron homoeostasis in yeast. Biochem J 432(3):595-605 {{SGDpaper|S000136719}} PMID 20858222</ref><ref name='S000041506'>Ivessa AS, et al. (2000) The Saccharomyces Pif1p DNA helicase and the highly related Rrm3p have opposite effects on replication fork progression in ribosomal DNA. Cell 100(4):479-89 {{SGDpaper|S000041506}} PMID 10693764</ref><ref name='S000123131'>Vega LR, et al. (2007) Sensitivity of yeast strains with long g-tails to levels of telomere-bound telomerase. PLoS Genet 3(6):e105 {{SGDpaper|S000123131}} PMID 17590086</ref><ref name='S000055909'>Zhou J, et al. (2000) Pif1p helicase, a catalytic inhibitor of telomerase in yeast. Science 289(5480):771-4 | + | '''Description of YML061C:''' DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells<ref name='S000150691'>Crider DG, et al. (2012) Rad53 is essential for a mitochondrial DNA inheritance checkpoint regulating G1 to S progression. J Cell Biol () {{SGDpaper|S000150691}} PMID 22927468</ref><ref name='S000046554'>Foury F and Lahaye A (1987) Cloning and sequencing of the PIF gene involved in repair and recombination of yeast mitochondrial DNA. EMBO J 6(5):1441-9 {{SGDpaper|S000046554}} PMID 3038524</ref><ref name='S000136719'>Guirola M, et al. (2010) Lack of DNA helicase Pif1 disrupts zinc and iron homoeostasis in yeast. Biochem J 432(3):595-605 {{SGDpaper|S000136719}} PMID 20858222</ref><ref name='S000041506'>Ivessa AS, et al. (2000) The Saccharomyces Pif1p DNA helicase and the highly related Rrm3p have opposite effects on replication fork progression in ribosomal DNA. Cell 100(4):479-89 {{SGDpaper|S000041506}} PMID 10693764</ref><ref name='S000123131'>Vega LR, et al. (2007) Sensitivity of yeast strains with long g-tails to levels of telomere-bound telomerase. PLoS Genet 3(6):e105 {{SGDpaper|S000123131}} PMID 17590086</ref><ref name='S000055909'>Zhou J, et al. (2000) Pif1p helicase, a catalytic inhibitor of telomerase in yeast. Science 289(5480):771-4 |
{{SGDpaper|S000055909}} PMID 10926538</ref> | {{SGDpaper|S000055909}} PMID 10926538</ref> | ||
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Latest revision as of 13:05, 13 September 2012
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| Systematic name | YML061C |
| Gene name | PIF1 |
| Aliases | TST1 |
| Feature type | ORF, Verified |
| Coordinates | Chr XIII:151532..148953 |
| Primary SGDID | S000004526 |
Description of YML061C: DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells[1][2][3][4][5][6]
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Contents
Community Commentary
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DNA and RNA Details
Other DNA and RNA Details
Other Topic: expression
Specifically lower expression in carbon limited chemostat cultures versus carbon excess. [7] [8]
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References
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- ↑ Crider DG, et al. (2012) Rad53 is essential for a mitochondrial DNA inheritance checkpoint regulating G1 to S progression. J Cell Biol () SGD PMID 22927468
- ↑ Foury F and Lahaye A (1987) Cloning and sequencing of the PIF gene involved in repair and recombination of yeast mitochondrial DNA. EMBO J 6(5):1441-9 SGD PMID 3038524
- ↑ Guirola M, et al. (2010) Lack of DNA helicase Pif1 disrupts zinc and iron homoeostasis in yeast. Biochem J 432(3):595-605 SGD PMID 20858222
- ↑ Ivessa AS, et al. (2000) The Saccharomyces Pif1p DNA helicase and the highly related Rrm3p have opposite effects on replication fork progression in ribosomal DNA. Cell 100(4):479-89 SGD PMID 10693764
- ↑ Vega LR, et al. (2007) Sensitivity of yeast strains with long g-tails to levels of telomere-bound telomerase. PLoS Genet 3(6):e105 SGD PMID 17590086
- ↑ Zhou J, et al. (2000) Pif1p helicase, a catalytic inhibitor of telomerase in yeast. Science 289(5480):771-4 SGD PMID 10926538
- ↑ Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. J Biol Chem 278(5):3265-74 SGD PMID 12414795
- ↑ submitted by Viktor Boer on 2003-07-25
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